Search Results - "Umpleby, A. M"

Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD by Shojaee-Moradie, F, Cuthbertson, D. J, Barrett, M, Jackson, N. C, Herring, R, Thomas, E. L, Bell, J, Kemp, G. J, Wright, J, Umpleby, A. M

“…Context: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces…”
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Leucine-enriched essential amino acid supplementation in mechanically ventilated trauma patients: a feasibility study by Wandrag, L, Brett, S J, Frost, G S, To, M, Loubo, E Alves, Jackson, N C, Umpleby, A M, Bountziouka, V, Hickson, M

“…Critically ill patients lose up to 2% of muscle mass per day. We assessed the feasibility of administering a leucine-enriched essential amino acid (L-EAA)…”
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Pathophysiology of postprandial hyperglycaemia in women with type 1 diabetes during pregnancy by Murphy, H. R., Elleri, D., Allen, J. M., Harris, J., Simmons, D., Rayman, G., Temple, R. C., Umpleby, A. M., Dunger, D. B., Haidar, A., Nodale, M., Wilinska, M. E., Hovorka, R.

“…Aims/hypothesis Although maternal hyperglycaemia is associated with increased risk of adverse pregnancy outcome, the mechanisms of postprandial hyperglycaemia…”
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Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism by Shojaee-Moradie, F, Baynes, K. C. R, Pentecost, C, Bell, J. D, Thomas, E. L, Jackson, N. C, Stolinski, M, Whyte, M, Lovell, D, Bowes, S. B, Gibney, J, Jones, R. H, Umpleby, A. M

“…Aims/hypothesis It is not known whether the beneficial effects of exercise training on insulin sensitivity are due to changes in hepatic and peripheral insulin…”
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Absorption patterns of meals containing complex carbohydrates in type 1 diabetes by Elleri, D., Allen, J. M., Harris, J., Kumareswaran, K., Nodale, M., Leelarathna, L., Acerini, C. L., Haidar, A., Wilinska, M. E., Jackson, N., Umpleby, A. M., Evans, M. L., Dunger, D. B., Hovorka, R.

“…Aims/hypothesis Successful postprandial glycaemia management requires understanding of absorption patterns after meals containing variable complex…”
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Pegvisomant Improves Insulin Sensitivity and Reduces Overnight Free Fatty Acid Concentrations in Patients with Acromegaly by Higham, C. E., Rowles, S., Russell-Jones, D., Umpleby, A. M., Trainer, P. J.

“…Introduction: Acromegaly is complicated by an increased incidence of diabetes mellitus caused by impaired insulin sensitivity and reduced β-cell function…”
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Short-Term Administration of Pegvisomant Improves Hepatic Insulin Sensitivity and Reduces Soleus Muscle Intramyocellular Lipid Content in Young Adults With Type 1 Diabetes by Thankamony, A, Tossavainen, P. H, Sleigh, A, Acerini, C, Elleri, D, Dalton, R. N, Jackson, N. C, Umpleby, A. M, Williams, R. M, Dunger, D. B

“…Context: Data on the metabolic effects of GH derived from studies using GH suppression by pharmacological agents may not reflect selective actions. Objective:…”
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Comparison of the effects on glucose and lipid metabolism of equipotent doses of insulin detemir and NPH insulin with a 16-h euglycaemic clamp by HORDERN, S. V. M, WRIGHT, J. E, UMPLEBY, A. M, SHOJAEE-MORADIE, F, AMISS, J, RUSSELL-JONES, D. L

“…The association of insulin detemir with non-esterified fatty acid binding sites on albumin may limit its transfer from the circulation into the extravascular…”
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Glucose Turnover After Replacement of Usual Therapy by Insulin in Insulin-naive Type 2 Diabetes Subjects by Thabit, H, Kumareswaran, K, Haidar, A, Leelarathna, L, Caldwell, K, Elleri, D, Allen, J. M, Nodale, M, Wilinska, M. E, Jackson, N. C, Umpleby, A. M, Evans, M. L, Hovorka, R

“…Context: Discontinuation of anti-hyperglycemic oral agents and initiation of insulin is recommended in certain clinical situations for inpatients with type 2…”
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High Dose Growth Hormone Exerts an Anabolic Effect at Rest and during Exercise in Endurance-Trained Athletes by Healy, M. L., Gibney, J., Russell-Jones, D. L., Pentecost, C., Croos, P., Sönksen, P. H., Umpleby, A. M.

“…The anabolic actions of GH in GH-deficient adults and children are well documented. Replacement with GH in such individuals promotes protein synthesis and…”
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Differential effects of insulin detemir and neutral protamine Hagedorn (NPH) insulin on hepatic glucose production and peripheral glucose uptake during hypoglycaemia in type 1 diabetes by Smeeton, F, Shojaee Moradie, F, Jones, R. H, Westergaard, L, Haahr, H, Umpleby, A. M, Russell-Jones, D. L

“…Aims/hypothesis We compared the symptoms of hypoglycaemia induced by insulin detemir (NN304) (B29Lys(ε-tetradecanoyl),desB30 human insulin) and equally…”
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Validity of triple- and dual-tracer techniques to estimate glucose appearance by Haidar, A, Elleri, D, Allen, J M, Harris, J, Kumareswaran, K, Nodale, M, Acerini, C L, Wilinska, M E, Jackson, N, Umpleby, A M, Evans, M L, Dunger, D B, Hovorka, R

“…The triple-tracer (TT) dilution technique has been proposed to be the gold standard method to measure postprandial glucose appearance. However, validation…”
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Severe Intrauterine Growth Retardation and Atypical Diabetes Associated with a Translocation Breakpoint Disrupting Regulation of the Insulin-Like Growth Factor 2 Gene by Murphy, R., Baptista, J., Holly, J., Umpleby, A. M., Ellard, S., Harries, L. W., Crolla, J., Cundy, T., Hattersley, A. T.

“…Context: IGF-II is an imprinted gene (predominantly transcribed from the paternally inherited allele), which has an important role in fetal growth in mice…”
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Effects of High-Dose Growth Hormone on Glucose and Glycerol Metabolism at Rest and during Exercise in Endurance-Trained Athletes by Healy, M. L., Gibney, J., Pentecost, C., Croos, P., Russell-Jones, D. L., Sönksen, P. H., Umpleby, A. M.

“…Context: Recombinant human-GH (r-hGH), in supraphysiological doses, is self-administered by athletes in the belief that it is performance enhancing. Objective:…”
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In treatment-naïve and antiretroviral-treated subjects with HIV, reduced plasma adiponectin is associated with a reduced fractional clearance rate of VLDL, IDL and LDL apolipoprotein B-100 by Das, S, Shahmanesh, M, Stolinski, M, Shojaee-Moradie, F, Jefferson, W, Jackson, N. C, Cobbold, M, Nightingale, P, Umpleby, A. M

“…Aims/hypothesis We hypothesised that loss of peripheral fat in HIV patients would result in decreased plasma adipocytokines, in particular adiponectin, and…”
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Effects of rosiglitazone and pioglitazone on lipoprotein metabolism in patients with Type 2 diabetes and normal lipids by Brackenridge, A. L., Jackson, N., Jefferson, W., Stolinski, M., Shojaee-Moradie, F., Hovorka, R, Umpleby, A. M., Russell-Jones, D.

“…Aims  Previous studies have suggested that plasma lipids are affected differently by the peroxisome proliferators‐activated receptor (PPAR)‐γ agonists…”
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Measurement of hepatic insulin sensitivity early after the bypass of the proximal small bowel in humans by Miras, A. D., Herring, R., Vusirikala, A., Shojaee‐Moradi, F., Jackson, N. C., Chandaria, S., Jackson, S. N., Goldstone, A. P., Hakim, N., Patel, A. G., Umpleby, A. M., Le Roux, C. W.

“…Summary Objective Unlike gastric banding or sleeve gastrectomy procedures, intestinal bypass procedures, Roux‐en‐Y gastric bypass in particular, lead to rapid…”
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Dietary exchange model to investigate the metabolic effects of extrinsic sugars on an atherogenic lipoprotein phenotype by Isherwood, C., Ahmad, A., Lovegrove, J. A., Frost, G. S., Umpleby, A. M., Griffin, B. A.

“…[...] the dietary exchange model was successful in achieving an intake of sugar diet that was close to the upper 2.5 percentile (28%E) for the intake of…”
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Exercise-induced improvements in liver fat and endothelial function are not sustained 12 months following cessation of exercise supervision in nonalcoholic fatty liver disease by Pugh, C J A, Sprung, V S, Jones, H, Richardson, P, Shojaee-Moradie, F, Umpleby, A M, Green, D J, Cable, N T, Trenell, M I, Kemp, G J, Cuthbertson, D J

“…Supervised exercise reduces liver fat and improves endothelial function, a surrogate of cardiovascular disease (CVD) risk, in nonalcoholic fatty liver disease…”
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Effect of Growth Hormone (GH) on Glycerol and Free Fatty Acid Metabolism during Exhaustive Exercise in GH-Deficient Adults by Gibney, J., Healy, M. L., Stolinski, M., Bowes, S. B., Pentecost, C., Breen, L., McMillan, C., Russell-Jones, D. L., Sonksen, P. H., Umpleby, A. M.

“…GH is an important regulator of fat metabolism at rest, but it is not known whether it regulates fat metabolism during exercise. To determine whether…”
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