Search Results - "Umoret, Remy"
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Developmental Impairments in a Rat Model of Methyl Donor Deficiency: Effects of a Late Maternal Supplementation with Folic Acid
Published in International journal of molecular sciences (23-02-2019)“…Vitamins B9 (folate) and B12 act as methyl donors in the one-carbon metabolism which influences epigenetic mechanisms. We previously showed that an embryofetal…”
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The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9-12 Vitamins
Published in International journal of molecular sciences (28-10-2020)“…A deficiency in B-vitamins is known to lead to persistent developmental defects in various organs during early life. The nervous system is particularly…”
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Vitamin B 12 Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions
Published in Molecular nutrition & food research (01-09-2021)“…Vitamin B deficiency presents various neurological manifestations, such as cognitive dysfunction, mental retardation, or memory impairment. However, the…”
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Brain Susceptibility to Methyl Donor Deficiency: From Fetal Programming to Aging Outcome in Rats
Published in International journal of molecular sciences (14-11-2019)“…Deficiencies in methyl donors, folate, and vitamin B12 are known to lead to brain function defects. Fetal development is the most studied but data are also…”
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Folate and Cobalamin Deficiencies during Pregnancy Disrupt the Glucocorticoid Response in Hypothalamus through N -Homocysteinilation of the Glucocorticoid Receptor
Published in International journal of molecular sciences (07-06-2023)“…Vitamin B9 (folate)/B12 (cobalamin) deficiency is known to induce brain structural and/or functional retardations. In many countries, folate supplementation,…”
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Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus
Published in International journal of molecular sciences (14-10-2019)“…The micronutrients vitamins B9 and B12 act as methyl donors in the one-carbon metabolism involved in transmethylation reactions which critically influence…”
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A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism
Published in Clinical epigenetics (05-10-2023)“…MTR gene encodes the cytoplasmic enzyme methionine synthase, which plays a pivotal role in the methionine cycle of one-carbon metabolism. This cycle holds a…”
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Glucocorticoid Receptor Activation Restores Learning Memory by Modulating Hippocampal Plasticity in a Mouse Model of Brain Vitamin B12 Deficiency
Published in Molecular neurobiology (01-03-2021)“…Cobalamin (Cbl, vitamin B 12 ) deficiency or inborn errors of Cbl metabolism can produce neurologic disorders resistant to therapies, including cognitive…”
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Cognitive Impairment Is Associated with AMPAR Glutamatergic Dysfunction in a Mouse Model of Neuronal Methionine Synthase Deficiency
Published in Cells (Basel, Switzerland) (27-04-2023)“…Impairment of one-carbon metabolism during pregnancy, either due to nutritional deficiencies in B9 or B12 vitamins or caused by specific genetic defects, is…”
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Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR
Published in Nucleic acids research (06-09-2018)“…Abstract The molecular mechanisms that underlie the neurological manifestations of patients with inherited diseases of vitamin B12 (cobalamin) metabolism…”
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N‐homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia
Published in The Journal of pathology (01-07-2019)“…The pathomechanisms that associate a deficit in folate and/or vitamin B12 and the subsequent hyperhomocysteinemia with pathological brain ageing are unclear…”
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The deficit in folate and vitamin B12 triggers liver macrovesicular steatosis and inflammation in rats with dextran sodium sulfate-induced colitis
Published in The Journal of nutritional biochemistry (01-10-2020)“…The risks of nonalcoholic steatohepatitis (NASH) and deficiency in vitamin B12 and folate (methyl donor deficiency, MDD) are increased in inflammatory bowel…”
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Foetal programming by methyl donor deficiency produces steato-hepatitis in rats exposed to high fat diet
Published in Scientific reports (17-11-2016)“…Non-alcoholic steatohepatitis (NASH) is a manifestation of metabolic syndrome, which emerges as a major public health problem. Deficiency in methyl donors…”
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Folate and Cobalamin Deficiencies during Pregnancy Disrupt the Glucocorticoid Response in Hypothalamus through IN/I-Homocysteinilation of the Glucocorticoid Receptor
Published in International journal of molecular sciences (01-06-2023)“…Vitamin B9 (folate)/B12 (cobalamin) deficiency is known to induce brain structural and/or functional retardations. In many countries, folate supplementation,…”
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Journal Article -
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Vitamin B12 Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions
Published in Molecular nutrition & food research (01-09-2021)“…Introduction Vitamin B12 deficiency presents various neurological manifestations, such as cognitive dysfunction, mental retardation, or memory impairment…”
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Journal Article -
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Glucocorticoid Receptor Activation Restores Learning Memory by Modulating Hippocampal Plasticity in a Mouse Model of Brain Vitamin B 12 Deficiency
Published in Molecular neurobiology (01-03-2021)“…Cobalamin (Cbl, vitamin B ) deficiency or inborn errors of Cbl metabolism can produce neurologic disorders resistant to therapies, including cognitive…”
Get full text
Journal Article