Search Results - "Umiker, Ben"

A Soluble Activin Receptor Type IIB Prevents the Effects of Androgen Deprivation on Body Composition and Bone Health by Koncarevic, Alan, Cornwall-Brady, Milton, Pullen, Abigail, Davies, Monique, Sako, Dianne, Liu, June, Kumar, Ravindra, Tomkinson, Kathleen, Baker, Theresa, Umiker, Ben, Monnell, Travis, Grinberg, Asya V, Liharska, Katia, Underwood, Kathryn W, Ucran, Jeffrey A, Howard, Elizabeth, Barberio, Joseph, Spaits, Matthew, Pearsall, Scott, Seehra, Jasbir, Lachey, Jennifer

“…Androgen deprivation, a consequence of hypogonadism, certain cancer treatments, or normal aging in men, leads to loss of muscle mass, increased adiposity, and…”
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217 Evaluating biomarkers of JTX-8064 (anti-LILRB2/ILT4 monoclonal antibody) in an ex vivo human tumor histoculture system to inform clinical development by Hashambhoy-Ramsay, Yasmin, Spaulding, Vikki, Priess, Michelle, O’Malley, Kristin, Gostissa, Monica, Stack, Edward, Smith, Jeff, Willer, Margaret, Umiker, Ben, Shaffer, Donald

“…BackgroundLeukocyte immunoglobulin-like receptor B2 (LILRB2; ILT4) is an immunoinhibitory protein expressed on the surface of myeloid cells that has been…”
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Abstract 1727: Tumor associated macrophages and resistance to immune checkpoint blockade: consideration of cancer indications for the clinical development of JTX-8064, an anti-LILRB2/ILT4 monoclonal antibody by McGrath, Lara, Mueller, Amy, Rahman, Tanzila, Smith, Jeffrey, Yore, Mark, Stack, Edward, O'Malley, Kristin, Dunn, Andrew, Legendre, Kristen, Shenwai, Reva, Willer, Margaret, Naumovski, Allison, Baeck, Johan, Umiker, Ben

“…Leukocyte immunoglobulin-like receptor B2 (LILRB2; ILT4) is expressed on myeloid cells and inhibits myeloid cell activation through binding Major…”
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Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors by Umiker, Ben, Hashambhoy-Ramsay, Yasmin, Smith, Jeff, Rahman, Tanzila, Mueller, Amy, Davidson, Rachel, Meyer, Christina, Patankar, Gayatri, Alam, Mohammad Murshid, Jaffe, Sarah, Krukenberg, Kristin, Goodman, Allison, Spaulding, Vikki, Priess, Michelle, Dhaneshwar, Abha, Wong, Masie, Diiorio, Alexa, O'Malley, Kristin, McGrath, Lara, Willer, Margaret, Pepper, Lauren, Gostissa, Monica, Kis-Toth, Katalin, Wiederschain, Dmitri, Cohen, Heather, Shaffer, Donald R

“…Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+…”
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Phase 1, first-in-human trial of JTX-8064, an anti-LILRB2/ILT4 monoclonal antibody, as monotherapy and in combination with anti-PD-1 in adult patients with advanced solid tumors (INNATE) by Papadopoulos, Kyriakos P., Lakhani, Nehal J., Yap, Timothy A., Naumovski, Allison L, Brown, Karen S, Umiker, Ben, McGrath, Lara, Zhang, Weidong, Stack, Edward, Riley, Gosia, Mota, Nancy, Tasillo, Christina, Laken, Haley, Trehu, Elizabeth G., Baeck, Johan

“…Abstract only TPS2672 Background: Leukocyte Immunoglobulin-like receptor B2 [LILRB2; immunoglobulin-like transcript 4 (ILT4)] is an immunoinhibitory protein…”
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Abstract 4532: Preclinical evaluation of JTX-1811, an anti-CCR8 antibody with enhanced ADCC activity, for preferential depletion of tumor-infiltrating regulatory T cells by Dépis, Fabien, Hu, Changyun, Weaver, Jessica, McGrath, Lara, Klebanov, Boris, Buggé, Joshua, Umiker, Ben, Fregeau, Christine, Upadhyay, Dhruvkumar, Singh, Anirudh, Xu, Chang-Ai, Spaulding, Vikki, Priess, Michelle, Wong, Masie, Naheed, Seema, Zhang, Yan, Legendre, Kristin, Stack, Edward C., Mora, Alessandro, Willer, Margaret, Meetze, Kristan, Gostissa, Monica, Meehl, Michael A., Shaffer, Donald R.

“…Introduction: Immune checkpoint blockade (ICB) has revolutionized the treatment of many cancers, still most patients do not respond to PD-1 or CTLA-4…”
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945 Overlapping and distinct patterns of LILRB receptors support complementary targeting approach in cancer by Smith, Jeffrey, Mueller, Amy, Spaulding, Vikki, Priess, Michelle, Bala, Krithi, Dunn, Andrew, Jaffe, Sarah, Thompson, Morgan, Jean-Christophe Pignon, Diiorio, Alexa, Cunha, Andre, Condurso, Heather, Kristin O’Malley, Petrillo, Olivia, Prashanna Balaji Venkatasubramanian, Young, Geneva, Meyer, Christina, Meehl, Michael, Kis-Toth, Katalin, Gostissa, Monica, Wiederschain, Dmitri, Umiker, Ben, Hashambhoy-Ramsay, Yasmin

“…BackgroundLeukocyte immunoglobulin-like receptors (LILRBs) are cell surface immunoinhibitory proteins that have been recently recognized as therapeutic targets…”
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