Search Results - "Umeyama, H"

Core I97L mutation in conjunction with P79Q is associated with persistent low HBV DNA and HBs antigen clearance in patients with chronic hepatitis B by Honda, T., Ishigami, M., Ishizu, Y., Kuzuya, T., Hayashi, K., Ishikawa, T., Murakami, Y., Iwadate, M., Umeyama, H., Toyoda, H., Kumada, T., Katano, Y., Goto, H., Hirooka, Y.

“…When considering treatment for chronic hepatitis B (CHB), it is important to discriminate between patients with persistent low HBV DNA and patients with active…”
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Protein dynamics determined by backbone conformation and atom packing by Higo, J, Umeyama, H

“…To study the factors determining the collective motions in thermal, conformational fluctuations of a globular protein, molecular dynamics simulations were…”
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Prediction of protein side-chain conformations by principal component analysis for fixed main-chain atoms by Ogata, K, Umeyama, H

“…A method of side-chain prediction without calculating the potential function is introduced. It is based on the assumption that similar side-chain conformations…”
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Factors X Nice I and II: two novel missense mutations (Met-40Val and Pro304Ser) in patient with coagulation factor X deficiency by Miyata, T, Fischer, F, Umeyama, H, Appert, A, Jambou, D, Kato, H

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Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome by Matsumoto, Masanori, Kokame, Koichi, Soejima, Kenji, Miura, Masayoshi, Hayashi, Syuhei, Fujii, Yasuhiko, Iwai, Asayuki, Ito, Etsuro, Tsuji, Yoichiro, Takeda-Shitaka, Mayuko, Iwadate, Mitsuo, Umeyama, Hideaki, Yagi, Hideo, Ishizashi, Hiromichi, Banno, Fumiaki, Nakagaki, Tomohiro, Miyata, Toshiyuki, Fujimura, Yoshihiro

“…We report here 7 new mutations in the ADAMTS13 gene responsible for Upshaw-Schulman syndrome (USS), a catastrophic phenotype of congenital thrombotic…”
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Charge State of His-57--Asp-102 Couple in a Transition State Analogue--Trypsin Complex: A Molecular Orbital Study by Umeyama, Hideaki, Hirono, Shuichi, Nakagawa, Setsuko

“…Ab initio molecular orbital studies have been made as a model for the deacylation step of trypsin. Ser-195 is modeled by H2O in which one H is replaced either…”
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Six missense mutations associated with type I and type II protein C deficiency and implications obtained from molecular modelling by Zheng, Y Z, Sakata, T, Matsusue, T, Umeyama, H, Kato, H, Miyata, T

“…The molecular basis of protein C deficiency was studied in three type I and three type II heterozygotes. Three probands showed thrombotic complications. All…”
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Factor IX Bm Kiryu: a Val-313-to-Asp substitution in the catalytic domain results in loss of function due to a conformational change of the surface loop: evidence obtained by chimaeric modelling by Miyata, T, Kuze, K, Matsusue, T, Komooka, H, Kamiya, K, Umeyama, H, Matsui, A, Kato, H, Yoshioka, A

“…Factor IX Kiryu is a naturally occurring mutant of factor IX that has 2.5% coagulant activity, even though normal plasma levels of factor IX antigen are…”
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Cysteine protease inhibitors with S-(3-nitro-2-pyridinesulfenyl)-cysteine residue in affinity analogs of peptide substrates by Matsueda, R, Umeyama, H, Kominami, E, Katunuma, N

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Three-dimensional Structure of Human Renin by AKAHANE, KENJI, UMEYAMA, HIDEAKI, NAKAGAWA, SETSUKO, MORIGUCHI, IKUO, HIROSE, SHIGEHISA, ILZUKA, KLNJI, MURAKAMI, KAZUO

“…A three-dimensional model of human renin has been constructed based on the assump-tion that the overall folding of the aspartyl proteases is very similar. As a…”
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Precursor Mediated Cycloaddition Reaction of Ethylene to the Si(100)c(4 × 2) Surface by Nagao, Masashi, Umeyama, Hirobumi, Mukai, Kozo, Yamashita, Yoshiyuki, Yoshinobu, Jun, Akagi, Kazuto, Tsuneyuki, Shinji

“…We report the direct observation of a precursor state for the cycloaddition reaction (the di-σ bond formation) of ethylene on Si(100)c(4 × 2) using…”
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Three-dimensional model of the human PAF receptor by Kajihara, A, Komooka, H, Kamiya, K, Yoneda, T, Yoneda, S, Nakamura, M, Shimizu, T, Umeyama, H

“…The amino acid sequence analysis of the human platelet-activating factor (PAF) receptor showed that residues thought to be important structurally and…”
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An automatic homology modeling method consisting of database searches and simulated annealing by Ogata, Koji, Umeyama, Hideaki

“…We introduce a method of homology modeling consisting of database searches and simulated annealing. All processes involving searches for homologous proteins,…”
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Quantum Chemical Studies on Enzymatic Reaction Mechanisms by UMEYAMA, HIDEAKI

“…Enzymatic reaction mechanisms are studied from a quantum chemical point of view. Calculations were performed by using ab initio molecular orbital method. The…”
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Protein structure prediction in structure based drug design by Takeda-Shitaka, Mayuko, Takaya, Daisuke, Chiba, Chieko, Tanaka, Hirokazu, Umeyama, Hideaki

“…The human genome and other genome sequencing projects have generated huge amounts of protein sequence information. Recently, a structural genomics project that…”
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Algorithm for normal mode analysis with general internal coordinates by Kamiya, Kenshu, Sugawara, Yoko, Umeyama, Hideaki

“…A technique for performing normal vibrational analysis for biological macromolecules using general internal coordinates is proposed. The technique is based on…”
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Searching for protein-protein interaction sites and docking by the methods of molecular dynamics, grid scoring, and the pairwise interaction potential of amino acid residues by Terashi, Genki, Takeda-Shitaka, Mayuko, Takaya, Daisuke, Komatsu, Katsuichiro, Umeyama, Hideaki

“…In CAPRI Rounds 1 and 2, we assumed that because there are many ionic charges that weaken electrostatic interaction forces in living cells, the hydrophobic…”
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Interaction between the antigen and antibody is controlled by the constant domains: Normal mode dynamics of the HEL–HyHEL‐10 complex by Adachi, Masaaki, Kurihara, Youji, Nojima, Hiroyuki, Takeda‐Shitaka, Mayuko, Kamiya, Kenshu, Umeyama, Hideaki

“…The antigen binding fragment (Fab) of a monoclonal antibody (HyHEL‐10) consists of variable domains (Fv) and constant domains (CL–CH1). Normal modes have been…”
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Dynamic Influence of the Two Membrane-Proximal Immunoglobulin-Like Domains upon the Peptide-Binding Platform Domain in Class I and Class II Major Histocompatibility Complexes: Normal Mode Analysis by Nojima, Hiroyuki, Kanou, Kazuhiko, Kamiya, Kenshu, Atsuda, Koichiro, Umeyama, Hideaki, Takeda-Shitaka, Mayuko

“…Major histocompatibility complexes (MHCs) mainly fall into class I and class II. The two classes have similar structures, with two membrane-proximal…”
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HUMAN FAMSD-BASE: High Quality Protein Structure Model Database for the Human Genome Using the FAMSD Homology Modeling Method by Kanou, Kazuhiko, Hirata, Tomoko, Iwadate, Mitsuo, Terashi, Genki, Umeyama, Hideaki, Takeda-Shitaka, Mayuko

“…Almost all proteins express their biological functions through the structural conformation of their specific amino acid sequences. Therefore, acquiring the…”
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