Search Results - "Umetsu, Hironori"

Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: Induction of actin disruption and tumor cell-selective toxicity by Yamaguchi, Hideaki, Noshita, Toshiro, Yu, Tao, Kidachi, Yumi, Kamiie, Katsuyoshi, Umetsu, Hironori, Ryoyama, Kazuo

“…Licorice extracts are used worldwide in foods and medicines, and glycyrrhetinic acid (GA) is a licorice component that has been reported to induce various…”
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Glycyrrhetinic Acid Induces Anoikis-Like Death and Cytoskeletal Disruption in the Central Nervous System Tumorigenic Cells by Yamaguchi, Hideaki, Kidachi, Yumi, Kamiie, Katsuyoshi, Noshita, Toshiro, Umetsu, Hironori, Ryoyama, Kazuo

“…We analyzed the effects of glycyrrhetinic acid (GA), a licorice compound, on the induction of anoikis-like death and cytoskeletal disruption in the central…”
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Isolation of Ursolic Acid from Apple Peels and Its Specific Efficacy as a Potent Antitumor Agent by Yamaguchi, Hideaki, Noshita, Toshiro, Kidachi, Yumi, Umetsu, Hironori, Hayashi, Masahiko, Komiyama, Kanki, Funayama, Shinji, Ryoyama, Kazuo

“…Dried apple peels were extracted with n-hexane, chloroform, and methanol successively. The portion of the chloroform extract that showed the strongest…”
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Differentiation of Serum-Free Mouse Embryo Cells into an Astrocytic Lineage is Associated with the Asymmetric Production of Early Neural, Neuronal and Glial Markers by Yamaguchi, Hideaki, Kidachi, Yumi, Umetsu, Hironori, Ryoyama, Kazuo

“…Serum-free mouse embryo (SFME) cells, the astrocyte progenitor cells in the central nervous system (CNS), were exposed to 10 ng/ml leukemia inhibitory factor…”
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Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation by Yamaguchi, Hideaki, Zhu, Jun, Yu, Tao, Sasaki, Kazuo, Umetsu, Hironori, Kidachi, Yumi, Ryoyama, Kazuo

“…The effects of bisphenol A (BPA) on the differentiation of serum-free mouse embryo (SFME) cells, the astrocyte progenitor cells in the central nervous system,…”
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Detection of 6-(Methylsulfinyl)hexyl Isothiocyanate (6-MITC) and Its Conjugate with N-Acetyl-L-cysteine (NAC) by High Performance Liquid Chromatograpy-Atmospheric Pressure Chemical Ionization Mass Spectrometry (HPLC-MS/APCI) by Yamaguchi, Hideaki, Noshita, Toshiro, Kidachi, Yumi, Umetsu, Hironori, Fuke, Yoko, Ryoyama, Kazuo

“…A method using high-performance liquid chromatography (HPLC) and atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) was established for the…”
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Mouse 11β-Hydroxysteroid Dehydrogenase Type 2 for Human Application: Homology Modeling, Structural Analysis and Ligand-Receptor Interaction by Yamaguchi, Hideaki, Akitaya, Tatsuo, Kidachi, Yumi, Kamiie, Katsuyoshi, Noshita, Toshiro, Umetsu, Hironori, Ryoyama, Kazuo

“…Mouse (m) 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) was homology-modeled, and its structure and ligand-receptor interaction were analyzed. The modeled…”
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The augmenting activity of 6-(Methylsulfinyl)hexyl isothiocyanate on cellular glutathione levels is less sensitive to thiol compounds than its cytotoxic activity by Kidachi, Y.(Aomori Univ. (Japan)), Noshita, T, Yamaguchi, H, Umetsu, H, Fuke, Y, Ryoyama, K

“…We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC). Thiol compounds abolished the…”
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Substrate specificity of aminopeptidase from the mid-gut gland of the scallop (Patinopecten yessoensis) by Umetsu, H. (Aomori Univ. (Japan)), Arai, M, Ota, T, Abe, K, Uchizawa, H, Sasaki, K

“…An action for various peptides and a kinetic study for amino acid p-nitroanilides (pNAs) and 4-methylcoumaryl-7-amides (MCAs) were performed with purified…”
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Purification and properties of an aminopeptidase from the mid-gut gland of scallop ( Patinopecten yessoensis) by Umetsu, Hironori, Arai, Mito, Ota, Toshinori, Kudo, Ryohei, Sugiura, Hitomi, Ishiyama, Hiroyuki, Sasaki, Kazuo

“…An aminopeptidase was isolated from the mid-gut gland of Patinopecten yessoensis. The enzyme was purified from an acetone-dried preparation by extracting,…”
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Differentiation of Serum-Free Mouse Embryo Cells into an Astrocytic Lineage is Associated with the Asymmetric Production of Early Neural, Neuronal and Glial Markers by Hideaki YAMAGUCHIa, Yumi KIDACHIa, Hironori UMETSUb, Kazuo RYOYAMAa

“…Serum-free mouse embryo (SFME) cells, the astrocyte progenitor cells in the central nervous system (CNS), were exposed to 10ng/ml leukemia inhibitory factor…”
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Detection of 6-(Methylsulfinyl)hexyl Isothiocyanate(6-MITC) and Its Conjugate with N-Acetyl-L-cysteine(NAC) by High Performance Liquid Chromatograpy-Atmospheric Pressure Chemical Ionization Mass Spectrometry(HPLC-MS/APCI) by Hideaki YAMAGUCHIa, Toshiro NOSHITAa, Yumi KIDACHIa, Hironori UMETSUb, Yoko FUKEc, Kazuo RYOYAMAa

“…A method using high-performance liquid chromatography (HPLC)and atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) was established for the…”
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Utilization of 6-(methylsulfinyl)hexyl isothiocyanate for sensitization of tumor cells to antitumor agents in combination therapies by Yamaguchi, Hideaki, Kidachi, Yumi, Kamiie, Katsuyoshi, Noshita, Toshiro, Umetsu, Hironori, Fuke, Yoko, Ryoyama, Kazuo

“…In the present study, we performed in silico and in vitro analyses to evaluate the chemosensitizing effects of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC)…”
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Intracellular accumulation of structurally varied isothiocyanates correlates with inhibition of nitric oxide production in proinflammatory stimuli-activated tumorigenic macrophage-like cells by Yamaguchi, Hideaki, Kamiie, Katsuyoshi, Kidachi, Yumi, Noshita, Toshiro, Umetsu, Hironori, Fuke, Yoko, Ryoyama, Kazuo

“…In the present study, we analyzed the intracellular accumulation of 6-(methylsulfinyl)hexyl isothiocyanate (6MITC) and its analogs in proinflammatory…”
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Selective cytotoxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells: Potential involvement of H-Ras downregulation by Yu, Tao, Yamaguchi, Hideaki, Noshita, Toshiro, Kidachi, Yumi, Umetsu, Hironori, Ryoyama, Kazuo

“…With the intensive need for the development of more effective and safer agents for chemoprevention and therapy of human cancer, natural products from plants…”
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Frequency of Mutations of the Transgene, which might Result in the Loss of the Glyphosate-Tolerant Phenotype, was Lowered in Roundup Ready® Soybeans by Ogasawara, Takeshi, Chikagawa, Yukie, Arakawa, Fumihiro, Nozaki, Asami, Itoh, Yoshio, Sasaki, Kazuo, Umetsu, Hironori, Watanabe, Takahiro, Akiyama, Hiroshi, Maitani, Tamio, Toyoda, Masatake, Kamada, Hiroshi, Goda, Yukihiro, Ozeki, Yoshihiro

“…Polymerase chain reaction (PCR) primers were prepared to amplify the DNA fragment between the genomic DNA sequence adjacent to the 5′-integration site of…”
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Action of carboxypeptidase W on oligopeptides containing carboxy-terminally amidated peptides by Umetsu, Hironori, Hishinuma, Kiyoshi, Wake, Hitoshi, Takeuchi, Michio, Ichishima, Eiji

“…Carboxypeptidase W sequentially liberated amino acids from the carboxy-terminus of angiotensin I, bradykinin, delta sleep-inducing peptide and neurotensin,…”
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Ligand-receptor Interaction between Triterpenoids and the 11β-Hydroxysteroid dehydrogenase type 2 (11βHSD2) Enzyme Predicts Their Toxic Effects against Tumorigenic r/m HM-SFME-1 Cells by Yamaguchi, Hideaki, Yu, Tao, Noshita, Toshiro, Kidachi, Yumi, Kamiie, Katsuyoshi, Yoshida, Kenji, Akitaya, Tatsuo, Umetsu, Hironori, Ryoyama, Kazuo

“…The present study deals with in silico prediction and in vitro evaluation of the selective cytotoxic effects of triterpenoids on tumorigenic human c-Ha-ras and…”
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Isolation of 2-Methylisocitrate Dehydratase, a New Enzyme Serving in the Methylcitric Acid Cycle for Propionate Metabolism, from Yallowia lipolytica by Aoki, Hiroyuki, Uchiyama, Hiroo, Umetsu, Hironori, Tabuchi, Takeshi

“…2-Methylisocitrate dehydratase (EC 4.2.1.-; (2S,3R)-3-hydroxybutane-l,2,3-tricarboxylate hydrolyase), a new enzyme functioning in the methylcitric acid cycle…”
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Homology modeling and structural analysis of 11β-hydroxysteroid dehydrogenase type 2 by Yamaguchi, Hideaki, Akitaya, Tatsuo, Yu, Tao, Kidachi, Yumi, Kamiie, Katsuyoshi, Noshita, Toshiro, Umetsu, Hironori, Ryoyama, Kazuo

“…11β-hydroxysteroid dehydrogenase type 2 (11βHSD2) was homology-modeled by a Boltzmann-weighted randomized modeling procedure, using the X-ray crystal structure…”
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