Search Results - "Umekar, Milind J."

Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease by Mangrulkar, Shubhada V., Wankhede, Nitu L., Kale, Mayur B., Upaganlawar, Aman B., Taksande, Brijesh G., Umekar, Milind J., Anwer, Md. Khalid, Dailah, Hamad Ghaleb, Mohan, Syam, Behl, Tapan

“…Neurodegenerative diseases (NDD) are incurable and the most prevalent cognitive and motor disorders of elderly. Mitochondria are essential for a wide range of…”
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Involvement of molecular chaperone in protein-misfolding brain diseases by Wankhede, Nitu L., Kale, Mayur B., Upaganlawar, Aman B., Taksande, Brijesh G., Umekar, Milind J., Behl, Tapan, Abdellatif, Ahmed A.H., Bhaskaran, Prasanna Mohana, Dachani, Sudarshan Reddy, Sehgal, Aayush, Singh, Sukhbir, Sharma, Neelam, Makeen, Hafiz A., Albratty, Mohammed, Dailah, Hamed Ghaleb, Bhatia, Saurabh, Al-Harrasi, Ahmed, Bungau, Simona

“…Protein misfolding causes aggregation and build-up in a variety of brain diseases. There are numeral molecules that are linked with the protein homeostasis…”
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Revisiting the Mitochondrial Function and Communication in Neurodegenerative Diseases by Wankhede, Nitu L, Kale, Mayur B, Umare, Mohit D, Lokhande, Sanket, Upaganlawar, Aman B, Wal, Pranay, Taksande, Brijesh G, Umekar, Milind J, Khandige, Prasanna Shama, Singh, Bhupendra, Sadananda, Vandana, Ramniwas, Seema, Behl, Tapan

“…Neurodegenerative disorders are distinguished by the progressive loss of anatomically or physiologically relevant neural systems. Atypical mitochondrial…”
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Chronic agmatine treatment prevents behavioral manifestations of nicotine withdrawal in mice by Kotagale, Nandkishor R., Chopde, Chandrabhan T., Umekar, Milind J., Taksande, Brijesh G.

“…Smoking cessation exhibits an aversive withdrawal syndrome characterized by both increases in somatic signs and affective behaviors including anxiety and…”
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Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases by Wankhede, Nitu L, Kale, Mayur B, Bawankule, Ashwini K, Aglawe, Manish M, Taksande, Brijesh G, Trivedi, Rashmi V, Umekar, Milind J, Jamadagni, Ankush, Walse, Prathamesh, Koppula, Sushruta, Kopalli, Spandana Rajendra

“…Avenanthramides (Avns) and their derivatives, a group of polyphenolic compounds found abundantly in oats (Avena sativa Linn.), have emerged as promising…”
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Recent Perspectives on Cardiovascular Toxicity Associated with Colorectal Cancer Drug Therapy by Kashyap, Monu Kumar, Mangrulkar, Shubhada V, Kushwaha, Sapana, Ved, Akash, Kale, Mayur B, Wankhede, Nitu L, Taksande, Brijesh G, Upaganlawar, Aman B, Umekar, Milind J, Koppula, Sushruta, Kopalli, Spandana Rajendra

“…Cardiotoxicity is a well-known adverse effect of cancer-related therapy that has a significant influence on patient outcomes and quality of life. The use of…”
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Neurodegenerative disorders associated with genes of mitochondria by Marde, Vaibhav S., Tiwari, Prerna L., Wankhede, Nitu L., Taksande, Brijesh G., Upaganlawar, Aman B., Umekar, Milind J., Kale, Mayur B.

“…Background Over the last decade, aggregating evidences suggested that there is a causative link between mutation in gene associated with mitochondrial…”
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Studies on meropenem and cefixime metal ion complexes for antibacterial activity by Umekar, Milind J., Lohiya, Radheshyam T., Gupta, Krishna R., Kotagale, Nandkishore R., Raut, Neha S.

“…Background The metal ion complexes of meropenem and cefixime with cadmium, silver, palladium, zinc, nickel, cobalt and copper were synthesized and…”
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Agmatine prevents the manifestation of impulsive burying and depression-like behaviour in progesterone withdrawn female rats by Vinchurney, Madhura Dixit, Dhokne, Mrunali D., Kotagale, Nandkishor, Umekar, Milind J., Taksande, Brijesh

“…Premenstrual dysphoric disorder (PMDD) is characterized by various physical and affective symptoms, including anxiety, irritability, anhedonia, social…”
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Enhanced transdermal permeation and anti-inflammatory potential of phospholipids complex-loaded matrix film of umbelliferone: Formulation development, physico-chemical and functional characterization by Telange, Darshan R., Nirgulkar, Shivendra B., Umekar, Milind J., Patil, Arun T., Pethe, Anil M., Bali, Nikhil R.

“…In the present study, umbelliferone - phospholipids complex - loaded matrix film (UPLC – MF) was developed with a goal of improving transdermal permeation and…”
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Agmatine as a novel intervention for Alzheimer's disease: Pathological insights and cognitive benefits by Katariya, Raj A., Sammeta, Shivkumar S., Kale, Mayur B., Kotagale, Nandkishor R., Umekar, Milind J., Taksande, Brijesh G.

“…Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and a significant societal burden. Despite…”
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Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats by Aglawe, Manish M., Kale, Mayur B., Rahangdale, Sandip R., Kotagale, Nandkishor R., Umekar, Milind J., Taksande, Brijesh G.

“…•Prenatal ethanol exposure impaired cognition and neurological symptoms.•Reduced hippocampal agmatine and BDNF were associated with neurocognitive…”
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Comprehensive developmental investigation on simvastatin enriched bioactive film forming spray using the quality by design paradigm: a prospective strategy for improved wound healing by Patel, Vrushali N, Patel, Heta V, Agrawal, Kashish, Soni, Ishika, Shah, Pranav, Mangrulkar, Shubhada V, Umekar, Milind J, Lalan, Manisha S

“…The use of topical antimicrobials in wound healing presents challenges like risk of drug resistance and toxicity to local tissue. Simvastatin (SIM), a…”
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Development of self-assembled nanocarriers to enhance antitumor efficacy of docetaxel trihydrate in MDA-MB-231 cell line by Rarokar, Nilesh R., Khedekar, Pramod B., Bharne, Ashish P., Umekar, Milind J.

“…Self-assembled nanocarriers (SANs) as a novel colloidal controlled delivery for docetaxel trihydrate (DTX) were engineered by high-pressure homogenization…”
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Agmatine alleviates ethanol withdrawal-associated cognitive impairment and neurochemical imbalance in rats by Kale, Mayur B., Chandurkar, Pranali A., Taksande, Brijesh G., Aglawe, Manish M., Rahangdale, Sandip R., Upaganlawar, Aman B., Kopalli, Spandana R., Umekar, Milind J., Wankhede, Nitu L.

“…The present study aimed to investigate the role of agmatine in the neurobiology underlying memory impairment during ethanol withdrawal in rats. Sprague-Dawley…”
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Modulation of cholesterol metabolism with Phytoremedies in Alzheimer’s disease: A comprehensive review by Koppula, Sushruta, Wankhede, Nitu L., Sammeta, Shivkumar S., Shende, Prajwali V., Pawar, Rupali S., Chimthanawala, Niyamat, Umare, Mohit D., Taksande, Brijesh G., Upaganlawar, Aman B., Umekar, Milind J., Kopalli, Spandana Rajendra, Kale, Mayur B.

“…Alzheimer's disease (AD) is a complex neurological ailment that causes cognitive decline and memory loss. Cholesterol metabolism dysregulation has emerged as a…”
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Investigation of the influence of cellulose polymer on solid phase transformation of carbamazepine by Wadher, Kamlesh J., Bajaj, Girija S., Trivedi, Rashmi V., Trivedi, Sagar S., Umekar, Milind J.

“…•The solubility of Carbamazepine anhydrous forms decreases when they convert to dihydrate.•The anhydrous form converts to Carbamazepine dihydrate via solution…”
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Agmatine reverses ethanol consumption in rats: Evidences for an interaction with imidazoline receptors by Taksande, Brijesh G., Nambiar, Shreesha, Patil, Shardha, Umekar, Milind J., Aglawe, Manish M., Kotagale, Nandkishor R.

“…Alcohol is one of the most widely abused recreational drugs, largely linked with serious health and social concerns. However, the treatment options for…”
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Agmatine inhibits nicotine withdrawal induced cognitive deficits in inhibitory avoidance task in rats: Contribution of α2-adrenoceptors by Kotagale, Nandkishor R., Ali, Mir Touseef, Chopde, Chandrabhan T., Umekar, Milind J., Taksande, Brijesh G.

“…Nicotine abstinence following chronic exposure is associated with impairments in memory and variety of cognitive functions. Daily nicotine (2 mg/kg, sc, four…”
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Chronic agmatine treatment prevents olanzapine-induced obesity and metabolic dysregulation in female rats by Dixit, Madhura P., Sammeta, Shivkumar S., Dhokne, Mrunali D., Mangrulkar, Shubhada, Upadhya, Manoj A., Umekar, Milind J., Taksande, Brijesh G., Kotagale, Nandkishor R.

“…Antipsychotic-induced obesity affects millions of people and is a serious health condition worldwide. Olanzapine is the most widely prescribed antipsychotic…”
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