Search Results - "Umehara, K"

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    Effect of cationic drugs on the transporting activity of human and rat OCT/Oct 1-3 in vitro and implications for drug-drug interactions by Umehara, K.-I., Iwatsubo, T., Noguchi, K., Usui, T., Kamimura, H.

    Published in Xenobiotica (01-09-2008)
    “…The inhibitory effects of cationic drugs (β-adrenoreceptor antagonists, calcium (Ca)-channel blocker, If channel inhibitor, antiarrhythmic drugs, and…”
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    Journal Article
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    Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats by Umehara, K.-I., Iwatsubo, T., Noguchi, K., Kamimura, H.

    Published in Xenobiotica (01-08-2007)
    “…The contribution of organic cation transporters to the saturable component in the hepatic uptake of 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium…”
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    Journal Article
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    Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates by Umehara, K.-I., Iwatsubo, T., Noguchi, K., Kamimura, H.

    Published in Xenobiotica (01-06-2007)
    “…In this study, the comparison of the transport of substrates (1-methyl-4-phenylpydinium (MPP) and tetraethyl ammonium (TEA)) and the inhibition potency of the…”
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    Journal Article
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    Effect of methionine on production of naphthoquinones in Impatiens balsamina root cultures and detection of some secondary metabolites by Sakunphueak, A, Tansakul, P, Umehara, K, Noguchi, H, Panichayupakaranant, P

    Published in Pharmaceutical biology (01-01-2013)
    “…Lawsone, lawsone methyl ether and 3,3'-methylelnebislawsone are the main active compounds of Impatiens balsamina L. (Balsaminaceae). These compounds possess…”
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    Journal Article
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    Comparative evaluation of absorption, distribution, and excretion of YM758, a novel If channel inhibitor, between albino and non-albino rats by Umehara, K.-I., Seya, K., Sonoda, T., Nakamura, E., Noguchi, K., Usui, T., Kamimura, H.

    Published in Xenobiotica (01-05-2008)
    “…1. YM758 is a novel If channel inhibitor for the treatment of stable angina and atrial fibrillation. The absorption, distribution, and excretion of YM758 have…”
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    Journal Article
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    Tissue distribution of YM758, a novel If channel inhibitor, in pregnant and lactating rats by Umehara, K.-I., Seya, K., Iwatsubo, T., Noguchi, K., Usui, T., Kamimura, H.

    Published in Xenobiotica (01-10-2008)
    “…In this study the tissue distribution of radioactivity in pregnant and lactating rats was investigated by quantitatively determining radioactivity…”
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    Journal Article
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    Effect of iodine intercalation on structural and physical properties of misfit cobaltates by Kato, M., Umehara, K., Goto, Y., Hirota, K., Yoshimura, K.

    “…We have studied the synthesis and physical properties of misfit cobaltates compounds intercalated by the iodine. The iodine atoms was successfully intercalated…”
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    Journal Article Conference Proceeding
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    Evaluation of the inhibitory and induction potential of YM758, a novel If channel inhibitor, for human P450-mediated metabolism by Umehara, K-I., Susaki, Y., van Teylingen, R. H. J., Neat, J. N., Ndikum-moffor, F., Noguchi, K., Usui, T., Parkinson, A., Kamimura, H.

    “…Summary This study was designed to examine the in vitro metabolism of YM758, a novel cardiovascular agent, and to evaluate its potential to cause drug…”
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    Journal Article
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    Pharmacokinetics of YK754, a novel If channel inhibitor in rats, dogs and humans by Umehara, K-I., Nakamata, T., Suzuki, K., Noguchi, K., Usui, T., Kamimura, H.

    “…Summary The pharmacokinetics of YM758, a novel funny If current channel (If channel) inhibitor, was investigated after single intravenous (i.v.) and oral…”
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    Journal Article
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    A CMOS image sensor with analog two-dimensional DCT-based compression circuits for one-chip cameras by Kawahito, S., Yoshida, M., Sasaki, M., Umehara, K., Miyazaki, D., Tadokoro, Y., Murata, K., Doushou, S., Matsuzawa, A.

    Published in IEEE journal of solid-state circuits (01-12-1997)
    “…This paper presents a CMOS image sensor with on-chip compression using an analog two-dimensional discrete cosine transform (2-D DCT) processor and a variable…”
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    Journal Article
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    Inhibition of Human Drug Metabolizing Cytochrome P450 by Buprenorphine by Umehara, Ken, Shimokawa, Yoshihiko, Miyamoto, Gohachiro

    Published in Biological & pharmaceutical bulletin (01-05-2002)
    “…The effects of buprenorphine, a powerful mixed agonist/antagonist analgesic, on several cytochrome P450 (CYP) isoform specific reactions in human liver…”
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    Journal Article
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    IL-12-induced tumor regression correlates with in situ activity of IFN-gamma produced by tumor-infiltrating cells and its secondary induction of anti-tumor pathways by Yu, Wen‐Gong, Ogawa, Makoto, Mu, Jie, Umehara, Kazunari, Tsujimura, Takahiro, Fujiwara, Hiromi, Hamaoka, Toshiyuki

    Published in Journal of leukocyte biology (01-10-1997)
    “…Administration of recombinant interleukin‐12 (rIL‐12) into CSA1M fibrosarcoma‐bearing mice results in complete regression of growing tumors. This tumor…”
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    Journal Article