Search Results - "Umberto Capece"

Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features by Capece, Umberto, Moffa, Simona, Improta, Ilaria, Di Giuseppe, Gianfranco, Nista, Enrico Celestino, Cefalo, Chiara M A, Cinti, Francesca, Pontecorvi, Alfredo, Gasbarrini, Antonio, Giaccari, Andrea, Mezza, Teresa

“…Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and…”
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Dapagliflozin improves myocardial flow reserve in patients with type 2 diabetes: the DAPAHEART Trial: a preliminary report by Leccisotti, Lucia, Cinti, Francesca, Sorice, Gian Pio, D’Amario, Domenico, Lorusso, Margherita, Guzzardi, Maria Angela, Mezza, Teresa, Gugliandolo, Shawn, Cocchi, Camilla, Capece, Umberto, Indovina, Luca, Ferraro, Pietro Manuel, Iozzo, Patricia, Crea, Filippo, Giordano, Alessandro, Giaccari, Andrea

“…Abstract Objective Cardiovascular (CV) outcome trials have shown that in patients with type 2 diabetes (T2D), treatment with sodium-glucose cotransporter-2…”
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Real-world evidence evaluation of LDL-C in hospitalized patients: a population-based observational study in the timeframe 2021-2022 by Capece, Umberto, Iacomini, Chiara, Mezza, Teresa, Cesario, Alfredo, Masciocchi, Carlotta, Patarnello, Stefano, Giaccari, Andrea, Di Giorgi, Nicoletta

“…European registries and retrospective cohort studies have highlighted the failure to achieve low-density lipoprotein-cholesterol (LDL-C) targets in many very…”
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Physical Activity and Type 2 Diabetes: In Search of a Personalized Approach to Improving β-Cell Function by Di Murro, Emanuela, Di Giuseppe, Gianfranco, Soldovieri, Laura, Moffa, Simona, Improta, Ilaria, Capece, Umberto, Nista, Enrico Celestino, Cinti, Francesca, Ciccarelli, Gea, Brunetti, Michela, Gasbarrini, Antonio, Pontecorvi, Alfredo, Giaccari, Andrea, Mezza, Teresa

“…Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases worldwide. Lifestyle interventions, including diet and physical activity (PA), are…”
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Dapagliflozin treatment is associated with a reduction of epicardial adipose tissue thickness and epicardial glucose uptake in human type 2 diabetes by Cinti, Francesca, Leccisotti, Lucia, Sorice, Gian Pio, Capece, Umberto, D'Amario, Domenico, Lorusso, Margherita, Gugliandolo, Shawn, Morciano, Cassandra, Guarneri, Andrea, Guzzardi, Maria Angela, Mezza, Teresa, Capotosti, Amedeo, Indovina, Luca, Ferraro, Pietro Manuel, Iozzo, Patricia, Crea, Filippo, Giordano, Alessandro, Giaccari, Andrea

“…We recently demonstrated that treatment with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) leads to an increase in myocardial flow reserve in patients…”
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Effects of PCSK9 inhibition on glucose metabolism and β-cell function in humans: a pilot study by Moffa, Simona, Mezza, Teresa, Ferraro, Pietro Manuel, Di Giuseppe, Gianfranco, Cefalo, Chiara M A, Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Ciccarelli, Gea, Mari, Andrea, Pontecorvi, Alfredo, Giaccari, Andrea

“…Anti-PCSK9 monoclonal antibodies are effective in reducing LDL-C and cardiovascular events by neutralizing circulating PCSK9. PCSK9, however, is also expressed…”
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Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis by Mezza, Teresa, Moffa, Simona, Ferraro, Pietro Manuel, Quero, Giuseppe, Capece, Umberto, Carfì, Andrea, Cefalo, Chiara M A, Cinti, Francesca, Sorice, Gian Pio, Impronta, Flavia, Mari, Andrea, Pontecorvi, Alfredo, Alfieri, Sergio, Holst, Jens J, Giaccari, Andrea

“…Abstract Objective Changes in bile flow after bariatric surgery may beneficially modulate secretion of insulin and incretins, leading to diabetes remission…”
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1535-P: Type 2 Diabetes Remission after Roux-en-Y Gastric Bypass Is Related to a Reduction of Pancreatic Noradrenergic Innervation and Beta-Cell Redifferentiation by Cinti, Francesca, Avolio, Adriana, Morciano, Cassandra, Gugliandolo, Shawn, Capece, Umberto, Mezza, Teresa, Soldovieri, Laura, Ciccarelli, Gea, Di Giuseppe, Gianfranco, Moffa, Simona, Giaccari, Andrea

“…Background: β cell dedifferentiation has been identified as the process responsible for the functional "disappearance" of β cells from the islets of diabetic…”
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140-OR: The Coronary Flow Reserve Increase after Dapagliflozin Treatment in Patients with Type 2 Diabetes Is Maintained after Four Years-A Four-Year DAPAHEART Follow-up Study by Morciano, Cassandra, Cinti, Francesca, Sorice, Gian Pio, Leccisotti, Lucia, Gugliandolo, Shawn, Capece, Umberto, Cappannoli, Luigi, D'Amario, Domenico, Mezza, Teresa, Di Giuseppe, Gianfranco, Ciccarelli, Gea, Soldovieri, Laura, Giaccari, Andrea

“…Introduction & Objective: Cardiovascular (CV) outcome trials have shown that in patients with type 2 diabetes (T2D), treatment with sodium-glucose…”
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Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional β cells in predicting diabetes by Mezza, Teresa, Ferraro, Pietro Manuel, Di Giuseppe, Gianfranco, Moffa, Simona, Cefalo, Chiara M.A., Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Quero, Giuseppe, Pontecorvi, Alfredo, Mari, Andrea, Alfieri, Sergio, Giaccari, Andrea

“…BACKGROUND. The appearance of hyperglycemia is due to insulin resistance, functional deficits in the secretion of insulin, and a reduction of ß cell mass…”
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First-phase insulin secretion: can its evaluation direct therapeutic approaches? by Di Giuseppe, Gianfranco, Ciccarelli, Gea, Soldovieri, Laura, Capece, Umberto, Cefalo, Chiara M.A., Moffa, Simona, Nista, Enrico C., Brunetti, Michela, Cinti, Francesca, Gasbarrini, Antonio, Pontecorvi, Alfredo, Giaccari, Andrea, Mezza, Teresa

“…β Cells can adapt to pathological metabolic conditions by implementing plasticity mechanisms to increase their mass and enhance insulin secretion, thus…”
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Reduced incretin effect precedes diabetes development following duodenopancreatectomy in individuals without diabetes by Di Giuseppe, Gianfranco, Soldovieri, Laura, Ciccarelli, Gea, Ferraro, Pietro Manuel, Quero, Giuseppe, Cinti, Francesca, Capece, Umberto, Moffa, Simona, Nista, Enrico Celestino, Gasbarrini, Antonio, Mari, Andrea, Alfieri, Sergio, Tondolo, Vincenzo, Pontecorvi, Alfredo, Holst, Jens Juul, Giaccari, Andrea, Mezza, Teresa

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1068-P: Reassessing Insulin Therapy In Diabetes of the Exocrine Pancreas-A Pilot Study by Ciccarelli, Gea, Di Giuseppe, Gianfranco, Brunetti, Michela, Soldovieri, Laura, Di Giorgi, Nicoletta, Iacomini, Chiara, Masciocchi, Carlotta, Patarnello, Stefano, Capece, Umberto, Morciano, Cassandra, Gugliandolo, Shawn, Avolio, Adriana, Moffa, Simona, Cinti, Francesca, Giaccari, Andrea, Mezza, Teresa

“…Cohort studies have demonstrated that subjects with diabetes of the exocrine pancreas (DEP) are mostly treated with basal bolus insulin. To reassess insulin…”
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The interlink between thyroid autoimmunity and type 1 diabetes and the impact on male and female fertility by Medenica, Sanja, Stojanovic, Vukasin, Capece, Umberto, Mazzilli, Rossella, Markovic, Milica, Zamponi, Virginia, Vojinovic, Tanja, Migliaccio, Silvia, Defeudis, Giuseppe, Cinti, Francesca

“…The aim of this review is to discuss the several interconnections between thyroid autoimmunity and type 1 diabetes in terms of epidemiology, immunoserology,…”
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1754-P: Reduced Incretin Effect Predicts Diabetes Appearance in a Cohort of Nondiabetic Subjects after Acute Beta-Cell Mass Reduction by DI GIUSEPPE, GIANFRANCO, MARIA ASSUNTA CEFALO, CHIARA, MOFFA, SIMONA, CICCARELLI, GEA, SOLDOVIERI, LAURA, CINTI, FRANCESCA, CAPECE, UMBERTO, IMPRONTA, FLAVIA, MARI, ANDREA, HOLST, JENS J., GIACCARI, ANDREA, MEZZA, TERESA

“…In type 2 diabetes incretin effect (IE) is reduced but still contributes to 20-35% of insulin response to oral glucose. One reason is the impairment of GIP and…”
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2110-P: Correlation between Ex Vivo Islet Proteomic Analysis and In Vivo Secretory Function in Humans by ASSUNTA CEFALO, CHIARA MARIA, MEZZA, TERESA, CINTI, FRANCESCA, MOFFA, SIMONA, CAPECE, UMBERTO, KULKARNI, ROHIT, GIACCARI, ANDREA

“…Insulin resistance and β-cell dysfunction are the main actors in the pathogenesis of type 2 diabetes mellitus, causing both quantitative and qualitative loss…”
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Beta-cell function and glucose metabolism in patients with chronic pancreatitis by Ciccarelli, Gea, Di Giuseppe, Gianfranco, Soldovieri, Laura, Quero, Giuseppe, Nista, Enrico Celestino, Brunetti, Michela, Cinti, Francesca, Moffa, Simona, Capece, Umberto, Tondolo, Vincenzo, Mari, Andrea, Gasbarrini, Antonio, Pontecorvi, Alfredo, Alfieri, Sergio, Giaccari, Andrea, Mezza, Teresa

“…•Chronic pancreatitis is the most frequent cause of diabetes secondary to pancreatic disease.•Alterations in insulin secretion can only be detected by…”
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134-OR: Effects of PCSK9 Inhibitors on Glucose Metabolism and ß-Cell Function in Humans by MOFFA, SIMONA, MEZZA, TERESA, ASSUNTA CEFALO, CHIARA MARIA, CINTI, FRANCESCA, SORICE, GIAN PIO, IMPRONTA, FLAVIA, CAPECE, UMBERTO, MARI, ANDREA, GIACCARI, ANDREA

“…PCSK9 inhibitors are monoclonal antibodies effective in reducing LDL-C and cardiovascular events by neutralizing circulating PCSK9. Since PCSK9 is also…”
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Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional [beta] cells in predicting diabetes by Mezza, Teresa, Ferraro, Pietro Manuel, Giuseppe, Gianfranco Di, Moffa, Simona, Cefalo, Chiara M.A, Cinti, Francesca, Impronta, Flavia, Capece, Umberto, Quero, Giuseppe, Pontecorvi, Alfredo, Mari, Andrea, Alfieri, Sergio, Giaccari, Andrea

“…BACKGROUND. The appearance of hyperglycemia is due to insulin resistance, functional deficits in the secretion of insulin, and a reduction of [beta] cell mass…”
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2295-PUB: Impaired First-Phase Insulin Secretion Predicts the Development of Hyperglycemia in a Human Model of Acute Beta-Cell Mass Reduction by MEZZA, TERESA, FERRARO, PIETRO MANUEL, GIUSEPPE, GIANFRANCO DI, ASSUNTA CEFALO, CHIARA MARIA, MOFFA, SIMONA, QUERO, GIUSEPPE, CINTI, FRANCESCA, IMPRONTA, FLAVIA, CAPECE, UMBERTO, ALFIERI, SERGIO, MARI, ANDREA, GIACCARI, ANDREA

“…β-cell functional defects temporally anticipate (and eventually cause) the subsequent development of hyperglycemia, whereas a significant reduction (∼50%) of…”
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