Search Results - "Umbach, David M."

A comprehensive genomic pan-cancer classification using The Cancer Genome Atlas gene expression data by Li, Yuanyuan, Kang, Kai, Krahn, Juno M, Croutwater, Nicole, Lee, Kevin, Umbach, David M, Li, Leping

“…The Cancer Genome Atlas (TCGA) has generated comprehensive molecular profiles. We aim to identify a set of genes whose expression patterns can distinguish…”
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Predicting tumor response to drugs based on gene-expression biomarkers of sensitivity learned from cancer cell lines by Li, Yuanyuan, Umbach, David M, Krahn, Juno M, Shats, Igor, Li, Xiaoling, Li, Leping

“…Human cancer cell line profiling and drug sensitivity studies provide valuable information about the therapeutic potential of drugs and their possible…”
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CDSeqR: fast complete deconvolution for gene expression data from bulk tissues by Kang, Kai, Huang, Caizhi, Li, Yuanyuan, Umbach, David M, Li, Leping

“…Abstract Background Biological tissues consist of heterogenous populations of cells. Because gene expression patterns from bulk tissue samples reflect the…”
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CDSeq: A novel complete deconvolution method for dissecting heterogeneous samples using gene expression data by Kang, Kai, Meng, Qian, Shats, Igor, Umbach, David M, Li, Melissa, Li, Yuanyuan, Li, Xiaoling, Li, Leping

“…Quantifying cell-type proportions and their corresponding gene expression profiles in tissue samples would enhance understanding of the contributions of…”
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Glypican 6 is a putative biomarker for metastatic progression of cutaneous melanoma by Li, Yuanyuan, Li, Melissa, Shats, Igor, Krahn, Juno M, Flake, Gordon P, Umbach, David M, Li, Xiaoling, Li, Leping

“…Due to the poor prognosis of advanced metastatic melanoma, it is crucial to find early biomarkers that help identify which melanomas will metastasize. By…”
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Putative biomarkers for predicting tumor sample purity based on gene expression data by Li, Yuanyuan, Umbach, David M, Bingham, Adrienna, Li, Qi-Jing, Zhuang, Yuan, Li, Leping

“…Tumor purity is the percent of cancer cells present in a sample of tumor tissue. The non-cancerous cells (immune cells, fibroblasts, etc.) have an important…”
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Pesticide exposure and depression among male private pesticide applicators in the agricultural health study by Beard, John D, Umbach, David M, Hoppin, Jane A, Richards, Marie, Alavanja, Michael C R, Blair, Aaron, Sandler, Dale P, Kamel, Freya

“…Pesticide exposure may be positively associated with depression. Few previous studies have considered the episodic nature of depression or examined individual…”
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Non-motor symptoms and striatal dopamine transporter binding in early Parkinson's disease by Liu, Rui, Umbach, David M., Tröster, Alexander I., Huang, Xuemei, Chen, Honglei

“…Non-motor symptoms (NMS) are common in Parkinson's disease (PD), but their relationships to nigrostriatal degeneration remain largely unexplored. We evaluated…”
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The Prevalence of ADHD in a Population-Based Sample by Rowland, Andrew S., Skipper, Betty J., Umbach, David M., Rabiner, David L., Campbell, Richard A., Naftel, Albert J., Sandler, Dale P.

“…Objective: Few studies of ADHD prevalence have used population-based samples, multiple informants, and Diagnostic and Statistical Manual of Mental Disorders…”
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Early-life Farm Exposures and Adult Asthma and Atopy in the Agricultural Lung Health Study by House, John S., PhD, Wyss, Annah B., PhD, Hoppin, Jane A., ScD, Richards, Marie, PhD, Long, Stuart, BS, Umbach, David M., PhD, Henneberger, Paul, MPH, ScD, Beane Freeman, Laura E., PhD, Sandler, Dale P., PhD, Long O’Connell, Elizabeth, BA, BSN, Barker Cummings, Christie, DrPH, London, Stephanie J., MD, DrPH

“…Abstract Background Previous studies, mostly from Europe, suggest that early-life farming exposures protect against childhood asthma and allergy; few data…”
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Endocrine-sensitive physical endpoints in newborns: ranges and predictors by Shah, Rachana, Alshaikh, Belal, Schall, Joan I., Kelly, Andrea, Ford, Eileen, Zemel, Babette S., Umbach, David M., Adgent, Margaret, Stallings, Virginia A.

“…Background In neonates, endocrine-sensitive physical endpoints, including breast and reproductive tissues, may reflect effects of fetal environmental exposure…”
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Reproductive Hormone Concentrations and Associated Anatomical Responses: Does Soy Formula Affect Minipuberty in Boys? by Chin, Helen B, Kelly, Andrea, Adgent, Margaret A, Patchel, Stacy A, James, Kerry, Vesper, Hubert W, Botelho, Julianne C, Chandler, Donald Walt, Zemel, Babette S, Schall, Joan I, Ford, Eileen G, Darge, Kassa, Stallings, Virginia A, Baird, Donna D, Rogan, Walter J, Umbach, David M

“…Abstract Context Soy formula feeding is common in infancy and is a source of high exposure to phytoestrogens, documented to influence vaginal cytology in…”
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Soy Formula and Epigenetic Modifications: Analysis of Vaginal Epithelial Cells from Infant Girls in the IFED Study by Harlid, Sophia, Adgent, Margaret, Jefferson, Wendy N, Panduri, Vijayalakshmi, Umbach, David M, Xu, Zongli, Stallings, Virginia A, Williams, Carmen J, Rogan, Walter J, Taylor, Jack A

“…Early-life exposure to estrogenic compounds affects the development of the reproductive system in rodent models and humans. Soy products, which contain…”
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Nonmotor symptoms and Parkinson disease in United States farmers and spouses by Shrestha, Srishti, Kamel, Freya, Umbach, David M, Beane Freeman, Laura E, Koutros, Stella, Alavanja, Michael, Sandler, Dale P, Chen, Honglei

“…Few studies have evaluated the presence of multiple nonmotor symptoms (NMS) in relation to Parkinson disease (PD). Therefore, we examined cross-sectional…”
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Dietary fat intake and risk for Parkinson's disease by Dong, Jing, Beard, John D., Umbach, David M., Park, YikYung, Huang, Xuemei, Blair, Aaron, Kamel, Freya, Chen, Honglei

“…Previous epidemiological studies have generated inconsistent results regarding the associations between dietary fat intakes and risk for Parkinson's disease…”
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Pesticides and Atopic and Nonatopic Asthma among Farm Women in the Agricultural Health Study by Hoppin, Jane A, Umbach, David M, London, Stephanie J, Henneberger, Paul K, Kullman, Greg J, Alavanja, Michael C. R, Sandler, Dale P

“…Risk factors for asthma among farm women are understudied. We evaluated pesticide and other occupational exposures as risk factors for adult-onset asthma…”
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IUTA: a tool for effectively detecting differential isoform usage from RNA-Seq data by Niu, Liang, Huang, Weichun, Umbach, David M, Li, Leping

“…Most genes in mammals generate several transcript isoforms that differ in stability and translational efficiency through alternative splicing. Such alternative…”
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House dust metagenome and pulmonary function in a US farming population by Lee, Mikyeong, Kaul, Abhishek, Ward, James M, Zhu, Qiyun, Richards, Marie, Wang, Ziyue, González, Antonio, Parks, Christine G, Beane Freeman, Laura E, Umbach, David M, Motsinger-Reif, Alison A, Knight, Rob, London, Stephanie J

“…Chronic exposure to microorganisms inside homes can impact respiratory health. Few studies have used advanced sequencing methods to examine adult respiratory…”
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TRPM7 and CaV3.2 channels mediate Ca2+ influx required for egg activation at fertilization by Bernhardt, Miranda L., Stein, Paula, Carvacho, Ingrid, Krapp, Christopher, Ardestani, Goli, Mehregan, Aujan, Umbach, David M., Bartolomei, Marisa S., Fissore, Rafael A., Williams, Carmen J.

“…The success of mammalian development following fertilization depends on a series of transient increases in egg cytoplasmic Ca2+, referred to as Ca2+…”
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Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula by Cao, Yang, Calafat, Antonia M, Doerge, Daniel R, Umbach, David M, Bernbaum, Judy C, Twaddle, Nathan C, Ye, Xiaoyun, Rogan, Walter J

“…In the United States, about 25% of infant formula sold is based on soy protein, which is an important source of estrogenic isoflavones in the human food…”
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