Search Results - "Uma, Serdar"

Trimethylamine-N-oxide (TMAO) Selectively Disrupts Endothelium-Dependent Hyperpolarization-Type Relaxations in a Time-Dependent Manner in Rat Superior Mesenteric Artery by Hamad, Abdelrahman, Ozkan, Melike Hacer, Uma, Serdar

“…The vascular action of trimethylamine-N-oxide (TMAO)—the gut microbiota-derived metabolite—in contributing cardiovascular disease is a controversial topic. A…”
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Effects of Atorvastatin and l-Arginine Treatments on Electrical Field Stimulation-mediated Relaxations in Pulmonary Arterial Rings of Monocrotaline-Induced Pulmonary Hypertensive Rats by Ozturk, Elif Inci, Uma, Serdar

“…This study aimed to examine the effect of monocrotaline (MCT)-induced pulmonary hypertension on electrical field stimulation (EFS)-mediated relaxation in rings…”
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Inhibition of acetylcholine-induced EDHF response by elevated glucose in rat mesenteric artery by Özkan, Melike Hacer, Uma, Serdar

“…The effects of high glucose on endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxations of isolated rat mesenteric artery and the possible…”
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Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease by Kazkayasi, Inci, Telli, Gokcen, Nemutlu, Emirhan, Uma, Serdar

“…The relationship between type 2 diabetes and Alzheimer's disease (AD) provides evidence that insulin and insulin sensitizers may be beneficial for the…”
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OMEPRAZOLE-INDUCED RELAXATION IN RAT AORTA IS PARTLY DEPENDENT ON ENDOTHELIUM by KELİCEN, PELİN, PEKİNER, CAN, SARIOĞLU, YUSUF, UMA, SERDAR

“…We investigated the effect of omeprazole (1×10 −5–3×10 −4 M), an inhibitor of H +,K +-ATPase, on rat aortic rings pre-contracted with phenylephrine (10 −6 M)…”
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TWO NEW NITRIC OXIDE SYNTHASE INHIBITORS: PYRIDOXAL AMINOGUANIDINE AND 8-QUINOLINECARBOXYLIC HYDRAZIDE SELECTIVELY INHIBIT BASAL BUT NOT AGONIST-STIMULATED RELEASE OF NITRIC OXIDE IN RAT AORTA by PEKİNER, CAN, KELİCEN, PELİN, UMA, SERDAR, MIWA, ICHITOMO

“…Structural modification at one of the guanidine nitrogens of l-arginine has led to the development of a number of compounds N G-monomethyl- l-arginine (…”
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β‐adrenergic Receptor Blocker ICI 118,551 Selectively Increases Intermediate‐Conductance Calcium‐Activated Potassium Channel (IKCa)‐Mediated Relaxations in Rat Main Mesenteric Artery by Ozkan, Melike Hacer, Uma, Serdar

“…Endothelial IKCa and/or SKCa channels play an important role in the control of vascular tone by participating in endothelium‐dependent relaxation. Whether β‐AR…”
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Allopurinol treatment reduced vascular remodeling and improved vascular functions in monocrotaline-induced pulmonary hypertensive rats by Gokcen, Telli, Inci, Kazkayasi, Inci, Ergonul E., Sevgen, Onder, Serdar, Uma

“…Increased oxidative stress and high uric acid are implicated in the pathogenesis of pulmonary hypertension (PH). This provides opportunity to benefit from…”
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The effects of 5-hydroxytryptophan on carrageenan-induced mouse paw oedemas by TELLI, Gokçen, KAZKAYASI, Inci, UMA, Serdar

“…ABSTRACT Objective 5-Hydroxytryptophan is the precursor compound of serotonin biosynthesis. The oral absorption of 5-Hydroxytryptophan is close to 100% and,…”
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Electrical field stimulation (EFS)-induced relaxations turn into contractions upon removal of extracellular calcium in rat mesenteric artery by Ozkan, Melike Hacer, Ozturk, Elif Inci, Uma, Serdar

“…(A) EFS-induced relaxations in normal Krebs–Henseleit solution turn into contractions upon removal of Ca2+ in rat mesenteric arterial rings precontracted with…”
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Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats by Kazkayasi, Inci, Ismail, Muhammad-Al-Mustafa, Parrado-Fernandez, Cristina, Björkhem, Ingemar, Pekiner, Can, Uma, Serdar, Cedazo-Minguez, Angel, Burul-Bozkurt, Nihan

“…•Growing evidence shows that diabetes enhances the risk for Alzheimer’s disease.•Insulin deprivation decreased seladin-1 expression.•Insulin deprivation…”
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Does Endothelium-derived Hyperpolarizing Factor Play a Role in Endothelium-dependent Component of Electrical Field Stimulation-induced Vasorelaxation of Rat Mesenteric Arterial Rings? by Ozkan, Melike Hacer, Uma, Serdar

“…Electrical field stimulation (EFS)-induced, nonadrenergic, noncholinergic vasodilation was investigated in rat mesenteric arterial rings. Tetrodotoxin (10M),…”
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Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes by Kazkayasi, Inci, Burul-Bozkurt, Nihan, Ismail, Muhammad-Al-Mustafa, Merino-Serrais, Paula, Pekiner, Can, Cedazo-Minguez, Angel, Uma, Serdar

“…Many studies have indicated a relationship between diabetes and Alzheimer's disease (AD). However, the molecular mechanism underlying this association has not…”
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Preparation and In Vitro/In Vivo Evaluation of Microparticle Formulations Containing Meloxicam by Eroglu, Hakan, Burul-Bozkurt, Nihan, Uma, Serdar, Oner, Levent

“…In this study, we have formulated chitosan-coated sodium alginate microparticles containing meloxicam (MLX) and aimed to investigate the correlation between in…”
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Absence of desensitization to the relaxant activity of streptozotocin in isosorbide dinitrate-tolerant rat aorta by Uma, S, Balcioglu, A

“…The effect of in-vitro isosorbide dinitrate (ISDN)-induced tolerance on the vasodilatory actions of streptozotocin, a nitric oxide containing compound, and…”
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The Effects of Superoxide Anion Generators on Responses to Exogenous Nitric Oxide and Non‐Adrenergic, Non‐Cholinergic Nerve Stimulation in Rat Isolated Penile Bulb by Ozakman, Selda, Uma, Serdar

“…: The effects of the superoxide anion generators, pyrogallol and hydroquinone on relaxations induced by electrical field stimulation (70 V, 0.7 msec., 0.5–8 Hz…”
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Torsion/Detorsion of the Testis Does Not Modify Responses to Nitric Oxide in Rat Isolated Penile Bulb by Ozkan, Melike H., Vural, İ. Mert, Moralioglu, Serdar, Uma, Serdar, Sarioglu, Yusuf

“…:  Ischaemia‐reperfusion damage induced by torsion/detorsion of the testicles may be a causative factor leading to erectile dysfunction through oxidative…”
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The Role of Nitric Oxide in Mediating Nonadrenergic, Noncholinergic Relaxation in Rat Pulmonary Artery by Gümüşel, Bülent, Orhan, Diclehan, Tolunay, Özden, Uma, Serdar

“…Experiments were undertaken to investigate the existence of inhibitory nonadrenergic, noncholinergic (i-NANC) nerve activity by using in vitro functional and…”
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Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro by Sarioglu, Yusuf, Yildirim, Sahin, Utkan, Tijen, Yildirim, M.Kemal, Uma, Serdar

“…The present experiments were designed to investigate the effects of omeprazole, a H +-K + ATPase inhibitor, on corporal smooth muscle tone in vitro. All…”
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Some arylacridine derivatives possessing potassium channel opening activity by Şimşek, Rahime, Özkan, Melike, Kısmetli, Emrah, Uma, Serdar, Şafak, Cihat

“…In this study, six new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridinedione derivatives ( 1–6) were synthesised and their functional effects…”
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