Search Results - "Uma, Manjappara V."

Fragment analogs as better mimics of obestatin by Nagaraj, ShreeRanga, Peddha, Muthukumar S., Manjappara, Uma. V.

“…Obestatin is a twenty three amino acid peptide produced in the stomach by post translational modification of the preproghrelin gene. Since its discovery in…”
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Capsaicin And Genistein Override The Action Of Obestatin To Decrease Lipid Accumulation In 3T3-L1 Cells by Reddy, Musunuru Suneel Kumar, Manjappara, Uma V.

“…Satiety peptides convey information about short-term energy reserves in the gut to the hypothalamus and aid in regulation of appetite and food intake…”
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Obestatin and Rosiglitazone Differentially Modulate Lipid Metabolism Through Peroxisome Proliferator-activated Receptor-γ (PPARγ) in Pre-adipose and Mature 3T3-L1 Cells by B. G., Mallikarjuna, Manjappara, Uma V.

“…Obestatin is a 23-residue peptide, obtained after posttranslational modification of preproghrelin. It has been shown, in Swiss albino mice, to upregulate…”
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Co-administration with Obestatin Reduces Accumulation of Subcutaneous Fat Due to Rosiglitazone Administration in DIO-C57BL/6 Mice by Mallikarjuna, B. G., Manjappara, Uma V.

“…It was observed previously that the gastro-peptide obestatin upregulated glycerolipid metabolism and PPARγ signalling in normal Swiss albino mice. In this…”
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Studies on the influence of CCK-8 on the ability of obestatin to reduce food intake, gain in body weight and related lipid parameters by Nagaraj, ShreeRanga, Manjappara, Uma V.

“…In an effort to mimic in part the redundancy of satiety peptides involved in energy homeostasis, the combined benefits of the well-established satiety peptide…”
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Capsaicin but not Genistein Influences Modulation of Lipid Parameters by Obestatin in DIO-C57BL/6 Mice by Reddy, Musunuru Suneel Kumar, Manjappara, Uma V.

“…Capsaicin from chillies and genistein from soya bean have been shown to reduce cholesterol and triglyceride levels effectively. This study was done to test the…”
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Impromptu Effects of Nt8U with Soyasaponins on Obesity-related Lipid Parameters in High Fat Fed C57BL/6 Mice by Singh, Govardhan R. S., Manjappara, Uma V.

“…Nt8U is a peptide analog of the N-terminal 13 residue fragment of the satiety peptide obestatin with Gly (8) being replaced by α-amino isobutyric acid (Aib)…”
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Obestatin and Nt8U influence glycerolipid metabolism and PPAR gamma signaling in mice by Nagaraj, ShreeRanga, Raghavan, Angad V., Rao, Sudha N., Manjappara, Uma V.

“…•Obestatin and Nt8U induce differential expression of transcripts which are markedly indicative of their involvement in glycerolipid metabolism and PPAR…”
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Selective reduction of fat accumulation by soyasaponins A and B in high fat fed C57BL/6J mice by Singh, R.S. Govardhan, Manjappara, Uma V.

“…•Effect of soyasaponins A and B was studied in high fat fed C57BL/6J mice.•Soyasaponins A and B selectively reduced fat depots.•Both soyasaponins A and B…”
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Fragments of obestatin as modulators of feed intake, circulating lipids, and stored fat by Nagaraj, ShreeRanga, Peddha, Muthukumar S., Manjappara, Uma V.

“…Obestatin, shown to reduce feed intake and gain in body weight in rodents, is a very attractive candidate to be used against obesity. In this study, we aimed…”
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NMR Structure Implications of Enhanced Efficacy of Obestatin Fragment Analogs by Krishnarjuna, B., Ganjiwale, Anjali D., Manjappara, Uma V., Raghothama, S.

“…Obestatin is a more recently discovered hormone that is encoded by the ghrelin gene and produced in the stomach and gut. We report NMR analysis on synthetic…”
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Effect of Obestatin and its Fragment Analog Nt8U on the Epididymal and Brain Tissue of DIO‐C57BL/6 Mice by Shilpa, T.S., Manjappara, Uma V.

“…Abstract only Imbalance in energy intake and energy expenditure due to change in lifestyles and genetic issues results in obesity which is a serious health…”
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Peptide−Small Molecule Hybrids via Orthogonal Deprotection−Chemoselective Conjugation to Cysteine-Anchored Scaffolds. A Model Study by Smith, Amos B, Savinov, Sergey N, Manjappara, Uma V, Chaiken, Irwin M

“…The feasibility of an orthogonal deprotection−conjugation protocol, holding the promise of libraries of functionally diverse chemical probes attached to…”
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Stereochemistry of Schellman motifs in peptides: Crystal structure of a hexapeptide with a C-terminus 6 → 1 hydrogen bond by Datta, Saumen, Uma, Manjappara V., Shamala, N., Balaram, P.

“…The Schellman motif is a widely observed helix terminating structural motif in proteins, which is generated when the C‐terminus residue adopts a left‐handed…”
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