Search Results - "Um, S L"

Non-Peptide RGD Surrogates Which Mimic a Gly-Asp β-Turn:  Potent Antagonists of Platelet Glycoprotein IIb−IIIa by Fisher, Matthew J, Gunn, Bruce, Harms, Cathy S, Kline, Allen D, Mullaney, Jeffrey T, Nunes, Anne, Scarborough, Robert M, Arfsten, Ann E, Skelton, Marshall A, Um, Suzane L, Utterback, Barbara G, Jakubowski, Joseph A

“…Cyclic heptapeptide 1, which contains an Arg-Gly-Asp sequence, has good affinity for the platelet receptor GPIIb−IIIa and was chosen for study by 1H NMR…”
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Evaluation of anti‐activated protein C antibody development in patients with severe sepsis from four clinical studies with drotrecogin alfa (activated) by YAN, S. B., BRANDT, J. T., CORRELL, N. L., UM, S. L., BOURDAGE, J. S.

“…Background: Drotrecogin alfa (activated) (DAA) is a recombinant human activated protein C (APC), which is an antithrombotic protein. Objectives: To evaluate…”
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Human group II 14 kDa phospholipase A2 activates human platelets by Polgár, J, Kramer, R M, Um, S L, Jakubowski, J A, Clemetson, K J

“…Recombinant human group II phospholipase A2 (sPLA2) added to human platelets in the low microg/ml range induced platelet activation, as demonstrated by…”
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p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2 by Kramer, R M, Roberts, E F, Um, S L, Börsch-Haubold, A G, Watson, S P, Fisher, M J, Jakubowski, J A

“…The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2) is responsible for thrombin-stimulated mobilization of arachidonic acid for the synthesis of…”
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Quantitative detection of platelet GPIIb-IIIa receptor antagonist activity using a flow cytometric method by Green, Lisa J., Marder, Philip, Um, Suzane L., Jakubowski, Joseph A., Lawrence, Jeffry B.

“…Platelet‐membrane surface receptors are important targets for pharmacologic intervention in cardiovascular disease. Among these, glycoprotein (GP) IIb‐IIIa is…”
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Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569] by Kinasewitz, Gary T, Yan, S Betty, Basson, Bruce, Comp, Philip, Russell, James A, Cariou, Alain, Um, Suzane L, Utterback, Barbara, Laterre, Pierre-Francois, Dhainaut, Jean-François

“…PROWESS (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis) was a phase III, randomized, double blind, placebo controlled,…”
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Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists by Sall, Daniel J, Arfsten, Ann E, Bastian, Jolie A, Denney, Michael L, Harms, Cathy S, McCowan, Jefferson R, Morin, John M, Rose, Jack W, Scarborough, Robert M, Smyth, Mark S, Um, Suzane L, Utterback, Barbara G, Vasileff, Robert T, Wikel, James H, Wyss, Virginia L, Jakubowski, Joseph A

“…The use of 5,6-bicyclic amidines as arginine surrogates in the design of a novel class of potent platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa)…”
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Evaluation of anti-activated protein C antibody development in patients with severe sepsis from four clinical studies with drotrecogin alpha (activated) by Yan, S B, Brandt, J T, Correll, N L, Um, S L, Bourdage, J S

“…Drotrecogin alpha (activated) (DAA) is a recombinant human activated protein C (APC), which is an antithrombotic protein. To evaluate the development of…”
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Fused bicyclic Gly-asp β-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere by FISHER, M. J, GIESE, U, RAPP, A, RÜHTER, G, RUTERBORIES, K. J, SALL, D. J, SCARBOROUGH, R. M, SCHOTTEN, T, STENZEL, W, TOWNER, R. D, UM, S. L, UTTERBACK, B. G, HARMS, C. S, WYSS, V. L, JAKUBOWSKI, J. A, KINNICK, M. D, LINDSTROM, T. D, MCCOWAN, J. R, MEST, H.-J, MORIN, J. M, MULLANEY, J. T, PAAL, M

“…6-[4-Amidinobenzoyl]amino]-tetralone-2-acetic acid is a potent antagonist of GPIIb-IIIa. Substitution in the meta position of the benzamidine, or replacement…”
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Phenothiazines as lipid peroxidation inhibitors and cytoprotective agents by Yu, Melvin J, McCowan, Jefferson R, Thrasher, K. Jeff, Keith, Priscilla T, Luttman, Charlotte A, Ho, Peter P. K, Towner, Richard D, Bertsch, Barbara, Horng, J. S

“…A series of phenothiazines was synthesized and evaluated as in vitro inhibitors of iron-dependent lipid peroxidation. The MIC (minimum tested concentration…”
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Dihydroisoquinolone RGD mimics. Exploration of the aspartate isostere by Fisher, Matthew J., Gunn, Bruce P., Harms, Cathy S., Kline, Allen D., Mullaney, Jeffrey T., Scarborough, Robert M., Skelton, Marshall A., Um, Suzane L., Utterback, Barbara G., Jakubowski, Joseph A.

“…Disubstituted 3,4-dihydroisoquinolones that contain an ether-linked benzamidine at C 6 and a β-substituted aspartate mimic at C 2 offer enhanced affinity for…”
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New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated) by Macias, William L, Yan, S Betty, Williams, Mark D, Um, Suzane L, Sandusky, George E, Ballard, Darryl W, Planquois, Jean-Michel S

“…It has been hypothesized that the protein C pathway is a pivotal link between the inflammation and coagulation cascades. The demonstration that a survival…”
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Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling by Zeng, Wei, Matter, William F, Yan, S Betty, Um, Suzane L, Vlahos, Chris J, Liu, Ling

“…OBJECTIVE:To explore whether the improvement in organ function and the vasoactive effect observed in the clinical studies of drotrecogin alfa (activated)…”
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Systemic host inflammatory and coagulation response in the Dengue virus primo-infection by Avila-Aguero, Marı́a L, Avila-Aguero, Claudio R, Um, Suzane L, Soriano-Fallas, Alejandra, Cañas-Coto, Alejandro, Yan, S.Betty

“…Dengue virus infection has been rising in tropical countries. Clinical manifestations range from fever and general malaise to hemorrhagic manifestations and…”
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Fused Bicyclic Gly-Asp β-Turn Mimics with Specific Affinity for GPIIb-IIIa by Fisher, Matthew J, Arfstan, Ann E, Giese, Ulrich, Gunn, Bruce P, Harms, Cathy S, Khau, Vien, Kinnick, Michael D, Lindstrom, Terry D, Martinelli, Michael J, Mest, Hans-Jürgen, Mohr, Michael, Morin, John M, Mullaney, Jeffrey T, Nunes, Anne, Paal, Michael, Rapp, Achim, Rühter, Gerd, Ruterbories, Ken J, Sall, Daniel J, Scarborough, Robert M, Schotten, Theo, Sommer, Birgit, Stenzel, Wolfgang, Towner, Richard D, Um, Suzane L, Utterback, Barbara G, Vasileff, Robert T, Vöelkers, Silke, Wyss, Virginia L, Jakubowski, Joseph A

“…Disubstituted isoquinolones 2 and 3 have affinity for GPIIb-IIIa and represent leads for further structural evaluation. Structure−activity studies centered on…”
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Platelet glycoprotein IIb–IIIa receptor (GPIIb–IIIa) antagonists derived from amidinoindoles by Sall, Daniel J., Arfsten, Ann E., Berry, Dennis R., Denney, Michael L., Harms, Cathy S., McCowan, Jefferson R., Ray, Judith K., Scarborough, Robert M., Um, Suzane L., Utterback, Barbara G., Jakubowski, Joseph A.

“…A series of substituted amidinoindoles have been prepared as mimics of the RGD sequence and were studied as antagonists of the platelet glycoprotein IIb–IIIa…”
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