Search Results - "Ulysse, Luckner"

Molecular Imaging of Neurovascular Cell Death in Experimental Cerebral Stroke by PET by Reshef, Ayelet, Shirvan, Anat, Waterhouse, Rikki N, Grimberg, Hagit, Levin, Galit, Cohen, Avi, Ulysse, Luckner G, Friedman, Gad, Antoni, Gunnar, Ziv, Ilan

“…Clinical molecular imaging of apoptosis is a highly desirable yet unmet challenge. Here we provide the first report on (18)F-labeled…”
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Initial Process Development and Scale-Up of the Synthesis of a Triple Reuptake Inhibitor ALB 109780 by Yang, Qiang, Ulysse, Luckner G, McLaws, Mark D, Keefe, Daniel K, Haney, Brian P, Zha, Congxiang, Guzzo, Peter R, Liu, Shuang

“…Early process development toward a triple reuptake inhibitor is described. Three different routes were evaluated; one of them was optimized and scaled up to…”
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Process Development and Optimization for Production of a Potassium Ion Channel Blocker, ICA-17043 by Mobele, Bingidimi I, Venkatraman, Sripathy, McNaughton-Smith, Grant, Gibb, Cameron, Ulysse, Luckner G, Lindmark, Carl A, Shaw, Stephen, Marron, Brian, Spear, Kerry, Suto, Mark J

“…A scalable process for the manufacture of a potassium ion channel blocker was developed and optimized. Key features of the process include an optimized…”
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Process Development and Pilot-Scale Synthesis of New Cyclization Conditions of Substituted Phenylacetamides to Tetrahydroisoquinoline-2-ones Using Eaton’s Reagent by Ulysse, Luckner G, Yang, Qiang, McLaws, Mark D, Keefe, Daniel K, Guzzo, Peter R, Haney, Brian P

“…Tetrahydroisoquinoline is a ubiquitous structural framework presented in numerous pharmacologically relevant molecules. Although accessible by the…”
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Photoregulation of cyclic peptide conformation by Ulysse, Luckner, Cubillos, Juanita, Chmielewski, Jean

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A Light‐Activated β‐Turn Scaffold within a Somatostatin Analog: NMR Structure and Biological Activity by Ulysse, Luckner G., Chmielewski, Jean

“…Somatostatin owes its biological activity to the presence of a well‐defined β‐turn centered around the tetrapeptide Phe‐Trp‐Lys‐Thr. We have developed a…”
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Process Development toward the Pilot Scale Synthesis of the Piperidine-Based Cocaine Analogue and Potent Dopamine and Norepinephrine Reuptake Inhibitor CTDP 31,446 by Mobele, Bingidimi I, Kinahan, Taryn, Ulysse, Luckner G, Gagnier, Steven V, Ironside, Michael D, Knox, Graham S, Mohammadi, Farahnaz

“…(+)-Methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate hydrochloride (CTDP 31,446) is known as a dopamine reuptake inhibitor. This cocaine analogue…”
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Process Development and Scale-Up of an Hsp90 Inhibitor by Duan, Shengquan, Venkatraman, Sripathy, Hong, Xuechuan, Huang, Kenneth, Ulysse, Luckner, Mobele, Bingidimi I, Smith, Alexander, Lawless, Lawrence, Locke, Andrew, Garigipati, Ravi

“…A scalable process for the manufacture of a Hsp90 inhibitor was developed and optimized. Key features in the seven-step process include a selective SNAr…”
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Research Article: A Light-Activated beta -Turn Scaffold within a Somatostatin Analog: NMR Structure and Biological Activity by Ulysse, Luckner G, Chmielewski, Jean

“…Somatostatin owes its biological activity to the presence of a well-defined beta -turn centered around the tetrapeptide Phe-Trp-Lys-Thr. We have developed a…”
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Restricting the flexibility of crosslinked, interfacial peptide inhibitors of HIV-1 protease by Ulysse, Luckner G., Chmielewski, Jean

“…Interfacial peptides of HIV-1 protease were crosslinked with varying length alkyl-chains containing either a single cis or trans double bond, or a triple bond…”
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The design and synthesis of a light activatable beta-turn scaffold and its incorporation into cyclic peptides and dimerization inhibitors of HIV-1 protease by Ulysse, Luckner Gerard

“…A light activatable $\beta$-turn scaffold was designed and incorporated into cyclic peptides. The scaffold is an azobenzene molecule capable of adopting two…”
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