The Predictive Value of Ischemia-Modified Albumin in Renal Ischemia-Reperfusion Injury

The aim of the study is to investigate the predictive value of ischemia-modified albumin (IMA) as an oxidative stress indicator in renal ischemia-reperfusion (I/R) injury. Forty female Wistar Albino rats were divided into 5 groups: Group-1, sham; group-2, 20 min I/R, group-3, 30 min I/R; group-4, 40...

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Bibliographic Details
Published in:	Urologia internationalis Vol. 103; no. 4; p. 473
Main Authors:	Aytac Ates, Huseyin, Yücetaş, Uğur, Erkan, Erkan, Yucetas, Esma, Ulusoy, Soner, Kadihasanoglu, Mustafa, Behzatoglu, Kemal, Culha, Mehmet Gokhan, Toktas, Mahmut Gokhan
Format:	Journal Article
Language:	English
Published:	Switzerland 01-11-2019
Subjects:	Animals Biomarkers - blood Female Kidney - blood supply Predictive Value of Tests Rats Rats, Wistar Reperfusion Injury - blood Serum Albumin, Human Ischemia-modified albumin Total oxidant status Total anti-oxidant status Ischemia reperfusion
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Summary:	The aim of the study is to investigate the predictive value of ischemia-modified albumin (IMA) as an oxidative stress indicator in renal ischemia-reperfusion (I/R) injury. Forty female Wistar Albino rats were divided into 5 groups: Group-1, sham; group-2, 20 min I/R, group-3, 30 min I/R; group-4, 40 min I/R; and group-5, 60 min I/R. Blood samples were taken, and nephrectomy was performed in the sham group before ischemia was induced. At the end of the defined periods for each group, reperfusion was achieved and a blood sample was taken and nephrectomy was performed. At the end of the 6-hour reperfusion period, the blood sample was taken again and the other kidney is removed. IMA in serum and total anti-oxidant status (TAS), total oxidant status (TOS), and oxidative stress index in both serum and tissue were examined. Serum IMA values were significantly different between the groups (p = 0.009), and there was a significantly difference in TOS values between ischemic serum (p = 0.024) and tissue samples (p = 0.02). However, there was no significant difference in serum and tissue TAS values after ischemia (p = 0.9). Serum IMA, TOS and TAS and tissue TOS and TAS values after reperfusion were not significantly different. There was a significant correlation between tubular damage and ischemia duration in histopathological examination of renal tissue after I/R (p < 0.0001). Serum IMA values increased in parallel with the duration of ischemia, and this increase was supported by histopathological damage findings.
ISSN:	1423-0399
DOI:	10.1159/000500929