Search Results - "Uludag, H"

Polymeric delivery of siRNA for dual silencing of Mcl-1 and P-glycoprotein and apoptosis induction in drug-resistant breast cancer cells by Aliabadi, H M, Mahdipoor, P, Uludağ, H

“…Enhanced survival mechanisms of malignant cells in combination with elevated levels of drug transporters can sustain an undesirable resistance against drug…”
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Bisphosphonates as a foundation of drug delivery to bone by Uludag, Hasan

“…Bisphosphonates are organic analogues of pyrophosphate that are resistant to hydrolysis. Bisphosphonates exhibit an exceptional affinity to bone, which led to…”
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Specific effects of PEGylation on gene delivery efficacy of polyethylenimine: Interplay between PEG substitution and N/P ratio by Fitzsimmons, R.E.B., Uludağ, H.

“…While an effective non-viral gene carrier, 25kDa branched polyethylenimine (PEI) is cytotoxic, and decreasing its toxicity while maintaining its functionality…”
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Delivery Systems for BMPs: Factors Contributing to Protein Retention at an Application Site by Uludag, Hasan, Gao, Tiejun, Porter, Thomas J, Friess, Wolfgang, Wozney, John M

“…BackgroundRecombinant human bone morphogenetic proteins (rhBMPs) are being tested in clinical studies for their capacity to elicit bone formation. Biomaterials…”
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Polymeric micelles for siRNA delivery by Falamarzian, A., Xiong, X.-B., Uludag, H., Lavasanifar, A.

“…Post-transcriptional gene silencing mechanism using small interfering RNA (siRNA) as a potential therapeutic modality has generated great interest in recent…”
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Characterization of absorbable collagen sponges as rhBMP-2 carriers by Friess, W, Uludag, H, Foskett, S, Biron, R, Sargeant, C

“…For clinical use recombinant human bone morphogenetic protein (rhBMP-2) is soaked onto an absorbable collagen sponge (ACS) for bone regeneration. Therefore,…”
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Bisphosphonate Conjugation to Proteins as a Means To Impart Bone Affinity by Uludag, Hasan, Kousinioris, Niki, Gao, Tiejun, Kantoci, Darko

“…Growth factors are endogenous proteins capable of stimulating new bone formation, but their clinical benefit for systemic stimulation of bone mass has not been…”
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Nanofibers as new-generation materials: From spinning and nano-spinning fabrication techniques to emerging applications by Barhoum, Ahmed, Pal, Kaushik, Rahier, Hubert, Uludag, Hasan, Kim, Ick Soo, Bechelany, Mikhael

“…[Display omitted] •Nanofibers have their unique properties among other nanomaterials.•This review summarizes the history and development of nanofibers.•It…”
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rhBMP-Collagen Sponges as Osteoinductive Devices: Effects of in Vitro Sponge Characteristics and Protein pI on in Vivo rhBMP Pharmacokinetics by ULUDAG, H., FRIESS, W., WILLIAMS, D., PORTER, T., TIMONY, G., D'AUGUSTA, D., BLAKE, C., PALMER, R., BIRON, B., WOZNEY, J.

“…Osteoinductive devices, comprised of biodegradable collagen scaffolds and recombinant human Bone Morphogenetic Proteins (rhBMPs), are being currently pursued…”
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Characterization of absorbable collagen sponges as recombinant human bone morphogenetic protein-2 carriers by Friess, W, Uludag, H, Foskett, S, Biron, R, Sargeant, C

“…For clinical use recombinant human bone morphogenetic protein-2 (rhBMP-2) is soaked onto an absorbable collagen sponge (ACS) for bone regeneration. Therefore,…”
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Bone Affinity of a Bisphosphonate-Conjugated Protein in Vivo by Uludag, Hasan, Gao, Tiejun, Wohl, Gregory R., Kantoci, Darko, Zernicke, Ronald F.

“…Growth factors capable of stimulating bone formation are potential therapeutic agents for osteoporosis treatment. It is essential, however, that a targeting…”
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Hydrogels of Thermoreversible Comb-Polymers Exhibit Increased Resistance for Dissolution by Jalil, A., Uludag, H.

“…The N‐isopropylacrylamide (NiPAM) polymers exhibit thermoreversible properties in aqueous solutions. The resiliency of NiPAM hydrogels is believed to influence…”
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Selective resistance of mouse islets versus immune cells to indoleamine 2, 3 dioxygenase induced tryptophan deprivation stress response by Jalili, R.B, Forouzandeh, F, Moeenrezakhanlou, A, Rayat, G, Rajotte, R, Uludag, H, Ghahary, A

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61 Photodynamic therapy against antibiotic resistant Pseudomonas aeruginosa isolates from CF patients by Torun, O.Y, Uludag, H, Pekcan, S, Sener, B, Dogru, D, Ozcelik, U

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Biomimetic mineralized collagen scaffolds and their effect on osteogenic differentiation by Luo, L., Uludag, H., Sone, E., Viswanathan, S.

“…During bone healing, MSCs differentiate into bone-forming osteoblasts. This process of osteogenic differentiation is partly driven by the main noncellular…”
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Biotinated bone morphogenetic protein-2: In vivo and in vitro activity by Uludag, H., Golden, J., Palmer, R., Wozney, J. M.

“…Recombinant human bone morphogenetic protein‐2 (rhBMP‐2) was biotinated, and the bioactivity of biotinated protein was assessed in vitro (alkaline phosphate…”
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Biodegradable amphiphilic poly(ethylene oxide)- block -polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery by Xiong, Xiao-Bing, Uludağ, Hasan, Lavasanifar, Afsaneh

“…Abstract The RNA interference (RNAi) technology has been successfully used in elucidating mechanisms behind various biological events. However, in the absence…”
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Secretion of recombinant proteins from hydroxyethyl methacrylate-methyl methacrylate capsules by Tse, M., Uludag, H., Sefton, M. V., Chang, P. L.

“…Current human gene therapy relies on genetic modification of the patient's own cells. An alternate nonautologous approach is to use universal cell lines…”
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Realizing the potential of gene‐based molecular therapies in bone repair by Rose, Laura, Uludağ, Hasan

“…ABSTRACT A better understanding of osteogenesis at genetic and biochemical levels is yielding new molecular entities that can modulate bone regeneration and…”
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Combinational siRNA delivery using hyaluronic acid modified amphiphilic polyplexes against cell cycle and phosphatase proteins to inhibit growth and migration of triple-negative breast cancer cells by Parmar, Manoj B., Meenakshi Sundaram, Daniel Nisakar, K.C., Remant Bahadur, Maranchuk, Robert, Montazeri Aliabadi, Hamidreza, Hugh, Judith C., Löbenberg, Raimar, Uludağ, Hasan

“…[Display omitted] Triple-negative breast cancer is an aggressive form of breast cancer with few therapeutic options if it recurs after adjuvant chemotherapy…”
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