Search Results - "Ulrike Heberlein"
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1
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila
Published in eLife (23-12-2014)“…Animals discriminate stimuli, learn their predictive value and use this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key…”
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2
Preferential Ethanol Consumption in Drosophila Models Features of Addiction
Published in Current biology (29-12-2009)“…Alcohol addiction is a common affliction with a strong genetic component [1]. Although mammalian studies have provided significant insight into the molecular…”
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3
Competing dopamine neurons drive oviposition choice for ethanol in Drosophila
Published in Proceedings of the National Academy of Sciences - PNAS (24-12-2013)“…The neural circuits that mediate behavioral choice evaluate and integrate information from the environment with internal demands and then initiate a behavioral…”
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4
A Neural Circuit Encoding the Experience of Copulation in Female Drosophila
Published in Neuron (Cambridge, Mass.) (05-06-2019)“…Female behavior changes profoundly after mating. In Drosophila, the mechanisms underlying the long-term changes led by seminal products have been extensively…”
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5
Sensory Neurons in the Drosophila Genital Tract Regulate Female Reproductive Behavior
Published in Neuron (Cambridge, Mass.) (26-02-2009)“…Females of many animal species behave very differently before and after mating. In Drosophila melanogaster, changes in female behavior upon mating are…”
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6
Tissue-specific activation of a single gustatory receptor produces opposing behavioral responses in Drosophila
Published in Genetics (Austin) (01-10-2012)“…Understanding sensory systems that perceive environmental inputs and neural circuits that select appropriate motor outputs is essential for studying how…”
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7
Enabling cell-type-specific behavioral epigenetics in Drosophila: a modified high-yield INTACT method reveals the impact of social environment on the epigenetic landscape in dopaminergic neurons
Published in BMC biology (10-04-2019)“…Epigenetic mechanisms play fundamental roles in brain function and behavior and stressors such as social isolation can alter animal behavior via epigenetic…”
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8
A Subset of Serotonergic Neurons Evokes Hunger in Adult Drosophila
Published in Current biology (21-09-2015)“…Hunger is a complex motivational state that drives multiple behaviors. The sensation of hunger is caused by an imbalance between energy intake and expenditure…”
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9
Acute ethanol responses in Drosophila are sexually dimorphic
Published in Proceedings of the National Academy of Sciences - PNAS (18-12-2012)“…In mammalian and insect models of ethanol intoxication, low doses of ethanol stimulate locomotor activity whereas high doses induce sedation. Sex differences…”
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10
Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons
Published in PLoS genetics (18-01-2024)“…Living in dynamic environments such as the social domain, where interaction with others determines the reproductive success of individuals, requires the…”
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11
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
Published in Genes & development (15-12-2006)“…The choice of self-renewal versus differentiation is a fundamental issue in stem cell and cancer biology. Neural progenitors of the Drosophila post-embryonic…”
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12
Oviposition preference for and positional avoidance of acetic acid provide a model for competing behavioral drives in Drosophila
Published in Proceedings of the National Academy of Sciences - PNAS (07-07-2009)“…Selection of appropriate oviposition sites is essential for progeny survival and fitness in generalist insect species, such as Drosphila melanogaster, yet…”
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13
A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila
Published in PloS one (01-04-2010)“…Dopamine is a mediator of the stimulant properties of drugs of abuse, including ethanol, in mammals and in the fruit fly Drosophila. The neural substrates for…”
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14
Glycogen synthase kinase-3/Shaggy mediates ethanol-induced excitotoxic cell death of Drosophila olfactory neurons
Published in Proceedings of the National Academy of Sciences - PNAS (08-12-2009)“…It has long been known that heavy alcohol consumption leads to neuropathology and neuronal death. While the response of neurons to an ethanol insult is…”
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15
An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol
Published in PloS one (22-07-2011)“…Anaplastic lymphoma kinase (Alk) is a gene expressed in the nervous system that encodes a receptor tyrosine kinase commonly known for its oncogenic function in…”
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16
A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway
Published in Disease models & mechanisms (01-05-2011)“…Prenatal exposure to ethanol in humans results in a wide range of developmental abnormalities, including growth deficiency, developmental delay, reduced brain…”
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17
GPCR Signaling Is Required for Blood-Brain Barrier Formation in Drosophila
Published in Cell (07-10-2005)“…The blood-brain barrier of Drosophila is established by surface glia, which ensheath the nerve cord and insulate it against the potassium-rich hemolymph by…”
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18
Happyhour, a Ste20 Family Kinase, Implicates EGFR Signaling in Ethanol-Induced Behaviors
Published in Cell (29-05-2009)“…The consequences of alcohol use disorders (AUDs) are devastating to individuals and society, yet few treatments are currently available. To identify genes…”
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19
EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior
Published in PloS one (31-01-2014)“…Epidermal Growth Factor Receptor (EGFR) signaling has a conserved role in ethanol-induced behavior in flies and mice, affecting ethanol-induced sedation in…”
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20
JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity
Published in PloS one (05-12-2012)“…Neuronal signal transduction by the JNK MAP kinase pathway is altered by a broad array of stimuli including exposure to the widely abused drug ethanol, but the…”
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