Search Results - "Ulrich Müller, Frank"

Universal Cardiac Induction of Human Pluripotent Stem Cells in Two and Three‐Dimensional Formats: Implications for In Vitro Maturation by Zhang, Miao, Schulte, Jan Sebastian, Heinick, Alexander, Piccini, Ilaria, Rao, Jyoti, Quaranta, Roberto, Zeuschner, Dagmar, Malan, Daniela, Kim, Kee‐Pyo, Röpke, Albrecht, Sasse, Philipp, Araúzo‐Bravo, Marcos, Seebohm, Guiscard, Schöler, Hans, Fabritz, Larissa, Kirchhof, Paulus, Müller, Frank Ulrich, Greber, Boris

“…Directed cardiac differentiation of human pluripotent stem cells (hPSCs) enables disease modeling, investigation of human cardiogenesis, as well as large‐scale…”
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In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein by MEHRHOF, Felix B, MÜLLER, Frank-Ulrich, BERGMANN, Martin W, PEIFENG LI, YIBIN WANG, SCHMITZ, Wilhelm, DIETZ, Rainer, VON HARSDORF, Rüdiger

“…A variety of pathologic stimuli lead to apoptosis of cardiomyocytes. Survival factors like insulin-like growth factor-I (IGF-I) exert anti-apoptotic effects in…”
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Molecular determinants of health and disease by Ludwig, Stephan, Blass-Kampmann, Sabine, Müller, Frank Ulrich

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Intravenous Sphingosylphosphorylcholine Protects Ischemic and Postischemic Myocardial Tissue in a Mouse Model of Myocardial Ischemia/Reperfusion Injury by Herzog, Christine, Schmitz, Martina, Levkau, Bodo, Herrgott, Ilka, Mersmann, Jan, Larmann, Jan, Johanning, Kai, Winterhalter, Michael, Chun, Jerold, Müller, Frank Ulrich, Echtermeyer, Frank, Hildebrand, Reinhard, Theilmeier, Gregor

“…HDL, through sphingosine-1-phosphate (S1P), exerts direct cardioprotective effects on ischemic myocardium. It remains unclear whether other HDL-associated…”
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Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice by Chelu, Mihail G, Sarma, Satyam, Sood, Subeena, Wang, Sufen, van Oort, Ralph J, Skapura, Darlene G, Li, Na, Santonastasi, Marco, Müller, Frank Ulrich, Schmitz, Wilhelm, Schotten, Ulrich, Anderson, Mark E, Valderrábano, Miguel, Dobrev, Dobromir, Wehrens, Xander H T

“…A trial fibrillation (AF), the most common human cardiac arrhythmia, is associated with abnormal intracellular Ca2+ handling. Diastolic Ca2+ release from the…”
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Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus by Kido-Nakahara, Makiko, Buddenkotte, Jörg, Kempkes, Cordula, Ikoma, Akihiko, Cevikbas, Ferda, Akiyama, Tasuku, Nunes, Frank, Seeliger, Stephan, Hasdemir, Burcu, Mess, Christian, Buhl, Timo, Sulk, Mathias, Müller, Frank-Ulrich, Metze, Dieter, Bunnett, Nigel W, Bhargava, Aditi, Carstens, Earl, Furue, Masutaka, Steinhoff, Martin

“…In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent…”
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Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K2P) channels in murine disease models: focus on TASK-1 by Wiedmann, Felix, Schulte, Jan S., Gomes, Bruna, Zafeiriou, Maria-Patapia, Ratte, Antonius, Rathjens, Franziska, Fehrmann, Edda, Scholz, Beatrix, Voigt, Niels, Müller, Frank Ulrich, Thomas, Dierk, Katus, Hugo A., Schmidt, Constanze

“…Understanding molecular mechanisms involved in atrial tissue remodeling and arrhythmogenesis in atrial fibrillation (AF) is essential for developing specific…”
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The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease by Peischard, Stefan, Ho, Huyen Tran, Piccini, Ilaria, Strutz-Seebohm, Nathalie, Röpke, Albrecht, Liashkovich, Ivan, Gosain, Hiteshika, Rieger, Bettina, Klingel, Karin, Eggers, Britta, Marcus, Katrin, Linke, Wolfgang A., Müller, Frank Ulrich, Ludwig, Stephan, Greber, Boris, Busch, Karin, Seebohm, Guiscard

“…A detailed description of pathophysiological effects that viruses exert on their host is still challenging. For the first time, we report a highly controllable…”
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Evidence for Arrhythmogenic Effects of A2A-Adenosine Receptors by Boknik, Peter, Drzewiecki, Katharina, Eskandar, John, Gergs, Ulrich, Hofmann, Britt, Treede, Hendrik, Grote-Wessels, Stephanie, Fabritz, Larissa, Kirchhof, Paulus, Fortmüller, Lisa, Müller, Frank Ulrich, Schmitz, Wilhelm, Zimmermann, Norbert, Kirchhefer, Uwe, Neumann, Joachim

“…Adenosine can be released from the heart and may stimulate four different cardiac adenosine receptors. A receptor subtype that couples to the generation of…”
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Nitric oxide synthase in muscular dystrophies: a re-evaluation by Buchwalow, Igor B, Minin, Evgeny A, Müller, Frank-Ulrich, Lewin, Geertje, Samoilova, Vera E, Schmitz, Wilhelm, Wellner, Maren, Hasselblatt, Martin, Punkt, Karla, Müller-Werdan, Ursula, Demus, Uta, Slezak, Jan, Koehler, Gabriele, Boecker, Werner

“…Duchenne and Becker muscular dystrophies (DMD and BMD) are associated with decreased total nitric oxide (NO). However, mechanisms leading to NO deficiency with…”
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Sphingosine‐1‐Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning by Keul, Petra, Borren, Marcel M. G. J., Ghanem, Alexander, Müller, Frank Ulrich, Baartscheer, Antonius, Verkerk, Arie O., Stümpel, Frank, Schulte, Jan Sebastian, Hamdani, Nazha, Linke, Wolfgang A., Loenen, Pieter, Matus, Marek, Schmitz, Wilhelm, Stypmann, Jörg, Tiemann, Klaus, Ravesloot, Jan‐Hindrik, Alewijnse, Astrid E., Hermann, Sven, Spijkers, Léon J. A., Hiller, Karl‐Heinz, Herr, Deron, Heusch, Gerd, Schäfers, Michael, Peters, Stephan L. M., Chun, Jerold, Levkau, Bodo

“…Background Sphingosine‐1‐phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia–reperfusion injury, and ischemic preconditioning. The…”
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Pathophysiological Mechanisms of Cardiac Dysfunction in Transgenic Mice with Viral Myocarditis by Rohrbeck, Matthias, Hoerr, Verena, Piccini, Ilaria, Greber, Boris, Schulte, Jan Sebastian, Hübner, Sara-Sophie, Jeworutzki, Elena, Theiss, Carsten, Matschke, Veronika, Stypmann, Jörg, Unger, Andreas, Ho, Huyen Tran, Disse, Paul, Strutz-Seebohm, Nathalie, Faber, Cornelius, Müller, Frank Ulrich, Ludwig, Stephan, Rescher, Ursula, Linke, Wolfgang A, Klingel, Karin, Busch, Karin, Peischard, Stefan, Seebohm, Guiscard

“…Viral myocarditis is pathologically associated with RNA viruses such as coxsackievirus B3 (CVB3), or more recently, with SARS-CoV-2, but despite intensive…”
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Role of protein phosphatases in regulation of cardiac inotropy and relaxation by Bokník, P, Khorchidi, S, Bodor, G S, Huke, S, Knapp, J, Linck, B, Lüss, H, Müller, F U, Schmitz, W, Neumann, J

“…We studied the effects of the protein phosphatase (PP) inhibitor cantharidin (Cant) on time parameters and force of contraction (FOC) in isometrically…”
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The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results by Schotten, Ulrich, Hatem, Stephane, Ravens, Ursula, Jaïs, Pierre, Müller, Frank-Ulrich, Goette, Andres, Rohr, Stephan, Antoons, Gudrun, Pieske, Burkert, Scherr, Daniel, Oto, Ali, Casadei, Barbara, Verheule, Sander, Cartlidge, David, Steinmeyer, Klaus, Götsche, Thorsten, Dobrev, Dobromir, Kockskämper, Jens, Lendeckel, Uwe, Fabritz, Larissa, Kirchhof, Paulus, Camm, A John

“…Atrial fibrillation (AF) is the most common sustained arrhythmia in the general population. As an age-related arrhythmia AF is becoming a huge socio-economic…”
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Receptor mechanisms involved in the 5‐HT‐induced inotropic action in the rat isolated atrium by Läer, Stephanie, Remmers, Freerk, Scholz, Hasso, Stein, Birgitt, Ulrich Müller, Frank, Neumann, Joachim

“…1 The effects of 5‐hydroxytryptamine (5‐HT) in rat cardiac preparations were studied. 5‐HT up to 10 μM failed to affect contractility in papillary muscles…”
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Critical Role of Transcription Factor Cyclic AMP Response Element Modulator in β1-Adrenoceptor-Mediated Cardiac Dysfunction by LEWIN, Geertje, MATUS, Marek, ENGELHARDT, Stefan, LOHSE, Martin J, SCHMITZ, Wilhelm, MÜLLER, Frank Ulrich, BASU, Abhijit, FREBEL, Karin, ROHSBACH, Sebastian Pius, SAFRONENKO, Andrej, SEIDL, Matthias Dodo, STÜMPEL, Frank, BUCHWALOW, Igor, KÖNIG, Simone

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cAMP response element binding protein is expressed and phosphorylated in the human heart by MÜLLER, F. U, BOKNIK, P, HORST, A, KNAPP, J, LINCK, B, SCHMITZ, W, VAHLENSIECK, U, BÖHM, M, DENG, M. C, SCHELD, H. H

“…In end-stage failing human hearts and in rat hearts after prolonged in vivo beta-adrenergic treatment, several proteins involved in the cAMP-dependent signal…”
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HDAC (Histone Deacetylase) Inhibitor Valproic Acid Attenuates Atrial Remodeling and Delays the Onset of Atrial Fibrillation in Mice by Scholz, Beatrix, Schulte, Jan Sebastian, Hamer, Sabine, Himmler, Kirsten, Pluteanu, Florentina, Seidl, Matthias Dodo, Stein, Juliane, Wardelmann, Eva, Hammer, Elke, Völker, Uwe, Müller, Frank Ulrich

“…BACKGROUND:A structural, electrical and metabolic atrial remodeling is central in the development of atrial fibrillation (AF) contributing to its initiation…”
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Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice by Ni, Li, Lahiri, Satadru K, Nie, Jiali, Pan, Xiaolu, Abu-Taha, Issam, Reynolds, Julia O, Campbell, Hannah M, Wang, Haihao, Kamler, Markus, Schmitz, Wilhelm, Müller, Frank Ulrich, Li, Na, Wei, Xiang, Wang, Dao Wen, Dobrev, Dobromir, Wehrens, Xander H T

“…Abnormal intracellular calcium (Ca2+) handling contributes to the progressive nature of atrial fibrillation (AF), the most common sustained cardiac arrhythmia…”
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Atrial proteomic profiling reveals a switch towards profibrotic gene expression program in CREM-IbΔC-X mice with persistent atrial fibrillation by Zhao, Shuai, Hulsurkar, Mohit M., Lahiri, Satadru K., Aguilar-Sanchez, Yuriana, Munivez, Elda, Müller, Frank Ulrich, Jain, Antrix, Malovannaya, Anna, Yiu, Chi Him Kendrick, Reilly, Svetlana, Wehrens, Xander H.T.

“…Overexpression of the CREM (cAMP response element-binding modulator) isoform CREM-IbΔC-X in transgenic mice (CREM-Tg) causes the age-dependent development of…”
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