Search Results - "Ulrich, Benjamin J."

Bcl6 and Blimp1 reciprocally regulate ST2+ Treg–cell development in the context of allergic airway inflammation by Koh, Byunghee, Ulrich, Benjamin J., Nelson, Andrew S., Panangipalli, Gayathri, Kharwadkar, Rakshin, Wu, Wenting, Xie, Markus M., Fu, Yongyao, Turner, Matthew J., Paczesny, Sophie, Janga, Sarath Chandra, Dent, Alexander L., Kaplan, Mark H.

“…Bcl6 is required for the development of T follicular helper cells and T follicular regulatory (Tfr) cells that regulate germinal center responses. Bcl6 also…”
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STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus by Fu, Yongyao, Wang, Jocelyn, Panangipalli, Gayathri, Ulrich, Benjamin J., Koh, Byunghee, Xu, Chengxian, Kharwadkar, Rakshin, Chu, Xiaona, Wang, Yue, Gao, Hongyu, Wu, Wenting, Sun, Jie, Tepper, Robert S., Zhou, Baohua, Janga, Sarath Chandra, Yang, Kai, Kaplan, Mark H.

“…T helper cell differentiation requires lineage-defining transcription factors and factors that have shared expression among multiple subsets. BATF is required…”
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BATF-Interacting Proteins Dictate Specificity in Th Subset Activity by Fu, Yongyao, Koh, Byunghee, Kuwahara, Makoto, Ulrich, Benjamin J, Kharwadkar, Rakshin, Yamashita, Masakatsu, Kaplan, Mark H

“…The basic leucine zipper (bZIP) transcription factor BATF is expressed in multiple Th subsets and cooperates with other factors to regulate gene transcription…”
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A conserved enhancer regulates Il9 expression in multiple lineages by Koh, Byunghee, Abdul Qayum, Amina, Srivastava, Rajneesh, Fu, Yongyao, Ulrich, Benjamin J., Janga, Sarath Chandra, Kaplan, Mark H.

“…Cytokine genes are regulated by multiple regulatory elements that confer tissue-specific and activation-dependent expression. The cis -regulatory elements of…”
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Loricrin and Cytokeratin Disorganisation in Severe Forms of Periodontitis by Catunda, Raisa Queiroz, Ho, Karen Ka-yan, Patel, Srushti, Roy, Christopher Bryant, Alexiou, Maria, Levin, Liran, Ulrich, Benjamin J., Kaplan, Mark H., Febbraio, Maria

“…The aim of this research was to investigate the role of the cornified epithelium, the outermost layer of the oral mucosa, engineered to prevent water loss and…”
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STAT3 Activation Impairs the Stability of Th9 Cells by Ulrich, Benjamin J, Verdan, Felipe Fortino, McKenzie, Andrew N J, Kaplan, Mark H, Olson, Matthew R

“…Th9 cells regulate multiple immune responses, including immunity to pathogens and tumors, allergic inflammation, and autoimmunity. Despite ongoing research…”
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An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment by Fu, Yongyao, Wang, Jocelyn, Zhou, Baohua, Pajulas, Abigail, Gao, Hongyu, Ramdas, Baskar, Koh, Byunghee, Ulrich, Benjamin J, Yang, Shuangshuang, Kapur, Reuben, Renauld, Jean-Christophe, Paczesny, Sophie, Liu, Yunlong, Tighe, Robert M, Licona-Limón, Paula, Flavell, Richard A, Takatsuka, Shogo, Kitamura, Daisuke, Tepper, Robert S, Sun, Jie, Kaplan, Mark H

“…Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9-responsive cell repertoire is still not well defined. Here, we found that…”
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Activin A Promotes Differentiation of a Pathogenic Multicytokine IL-9-secreting CD4+ T Cell Population by Ulrich, Benjamin J, Zhang, Wenwu, Kenworthy, Blake T, Kharwadkar, Rakshin, Olson, Matthew R, Kaplan, Mark H

“…The development of Th subsets results from cellular and cytokine cues that are present in the inflammatory environment. The developing T cell integrates…”
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ERG Functionally Overlaps with Other Ets Proteins in Promoting TH9 Cell Expression of Il9 during Allergic Lung Inflammation by Kharwadkar, Rakshin, Ulrich, Benjamin J, Chu, Michelle, Koh, Byunghee, Hufford, Matthew M, Fu, Yongyao, Birdsey, Graeme M, Porse, Bo T, Randi, Anna M, Kaplan, Mark H

“…CD4+ TH cells develop into subsets that are specialized in the secretion of particular cytokines to mediate restricted types of inflammation and immune…”
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Interleukin-9 promotes mast cell progenitor proliferation and CCR2-dependent mast cell migration in allergic airway inflammation by Pajulas, Abigail, Fu, Yongyao, Cheung, Cherry C.L., Chu, Michelle, Cannon, Anthony, Alakhras, Nada, Zhang, Jilu, Ulrich, Benjamin J., Nelson, Andrew S., Zhou, Baohua, Kaplan, Mark H.

“…[Display omitted] Allergic asthma is a chronic lung disease characterized by airway hyperresponsiveness and cellular infiltration that is exacerbated by…”
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Predictive biomarker modeling of pediatric atopic dermatitis severity based on longitudinal serum collection by Engle, Sarah M, Chang, Ching-Yun, Ulrich, Benjamin J, Satterwhite, Allyson, Hayes, Tristan, Robling, Kim, Sissons, Sean E, Schmitz, Jochen, Tepper, Robert S, Kaplan, Mark H, Sims, Jonathan T

“…The pathogenesis of atopic dermatitis (AD) results from complex interactions between environmental factors, barrier defects, and immune dysregulation resulting…”
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Pancreas transplantation for cystic fibrosis: A frequently missed opportunity by Fridell, Jonathan A., Bozic, Molly A., Ulrich, Benjamin J., Lutz, Andrew J., Powelson, John A.

“…Cystic fibrosis (CF) is an inherited autosomal recessive disorder. Despite optimized therapy, the majority of affected individuals ultimately die of…”
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Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production by Olson, Matthew R, Ulrich, Benjamin J, Hummel, Sarah A, Khan, Ibrahim, Meuris, Brice, Cherukuri, Yesesri, Dent, Alexander L, Janga, Sarath Chandra, Kaplan, Mark H

“…IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17…”
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Allergic airway recall responses require IL-9 from resident memory CD4 + T cells by Ulrich, Benjamin J, Kharwadkar, Rakshin, Chu, Michelle, Pajulas, Abigail, Muralidharan, Charanya, Koh, Byunghee, Fu, Yongyao, Gao, Hongyu, Hayes, Tristan A, Zhou, Hong-Ming, Goplen, Nick P, Nelson, Andrew S, Liu, Yunlong, Linnemann, Amelia K, Turner, Matthew J, Licona-Limón, Paula, Flavell, Richard A, Sun, Jie, Kaplan, Mark H

“…Asthma is a chronic inflammatory lung disease with intermittent flares predominately mediated through memory T cells. Yet, the identity of long-term memory…”
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Comparative Analysis of Alternative Splicing Profiles in Th Cell Subsets Reveals Extensive Cell Type-Specific Effects Modulated by a Network of Transcription Factors and RNA-Binding Proteins by Mir, Quoseena, Lakshmipati, Deepak K, Ulrich, Benjamin J, Kaplan, Mark H, Janga, Sarath Chandra

“…Alternative splicing (AS) plays an important role in the development of many cell types; however, its contribution to Th subsets has been clearly defined. In…”
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Selectin Dependence of Allergic Skin Inflammation Is Diminished by Maternal Atopy by Khan, Ibrahim M, Ulrich, Benjamin J, Nelson, Andrew S, Sehra, Sarita, Kansas, Geoffrey S, Kaplan, Mark H

“…Allergic skin inflammation requires the influx of inflammatory cells into the skin. Extravasation of leukocytes into the skin requires interactions between…”
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Expression Efficiency of Multiple Il9 Reporter Alleles Is Determined by Cell Lineage by Kharwadkar, Rakshin, Ulrich, Benjamin J, Abdul Qayum, Amina, Koh, Byunghee, Licona-Limón, Paula, Flavell, Richard A, Kaplan, Mark H

“…Generation of allelic gene reporter mice has provided a powerful tool to study gene function in vivo. In conjunction with imaging technologies, reporter mouse…”
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IL-9 regulates type-2 CD4 tissue resident memory cell mediated allergic airway recall responses by Kharwadkar, Rakshin P, Ulrich, Benjamin J, Chu, Michelle, Fu, Yongyao, Pajulas, Abigail, Kaplan, Mark H

“…Abstract Allergic asthma is a chronic inflammatory lung disease with intermittent flares where patients experience symptoms mediated by memory T cells…”
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Identification of splice isoforms in T helper cells using Nanopore-based cDNA sequencing by Mir, Quoseena, Srivastava, Rajneesh, Ulrich, Benjamin J, Kaplan, Mark H, Janga, Sarath Chandra

“…Abstract The T helper (Th) cell compartment of the adaptive immune response provides a central mechanism of balance between inflammation and immune tolerance…”
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A single cell approach to identify the role of IL-9 secreting tissue-resident CD4+ T cells in allergic airway recall responses by Kharwadkar, Rakshin P, Ulrich, Benjamin J, Fu, Yongyao, Koh, Byunghee, Nelson, Andrew Scott, Kaplan, Mark H

“…Abstract Allergic asthma is a chronic intermittent inflammatory lung disease where patients experience relatively few symptoms between exacerbations…”
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