Search Results - "Ulicna, Livia"

Phospholipids and inositol phosphates linked to the epigenome by Uličná, Lívia, Paprčková, Darina, Fáberová, Veronika, Hozák, Pavel

“…Even though the majority of knowledge about phospholipids comes from their cytoplasmic functions, in the last decade, it has been shown that nuclear…”
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Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1 by Zhao, Meng, Banhos Danneskiold-Samsøe, Niels, Ulicna, Livia, Nguyen, Quennie, Voilquin, Laetitia, Lee, David E, White, James P, Jiang, Zewen, Cuthbert, Nickeisha, Paramasivam, Shrika, Bielczyk-Maczynska, Ewa, Van Rechem, Capucine, Svensson, Katrin J

“…The secreted protein isthmin-1 (Ism1) mitigates diabetes by increasing adipocyte and skeletal muscle glucose uptake by activating the PI3K-Akt pathway…”
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Multiple Aspects of PIP2 Involvement in C. elegans Gametogenesis by Ulicna, Livia, Rohozkova, Jana, Hozak, Pavel

“…One of the most studied phosphoinositides is phosphatidylinositol 4,5-bisphosphate (PIP2), which localizes to the plasma membrane, nuclear speckles, small foci…”
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Nuclear phosphatidylinositol 4,5-bisphosphate islets contribute to efficient RNA polymerase II-dependent transcription by Sobol, Margarita, Krausová, Alžběta, Yildirim, Sukriye, Kalasová, Ilona, Fáberová, Veronika, Vrkoslav, Vladimír, Philimonenko, Vlada, Marášek, Pavel, Pastorek, Lukáš, Čapek, Martin, Lubovská, Zuzana, Uličná, Lívia, Tsuji, Takuma, Lísa, Miroslav, Cvačka, Josef, Fujimoto, Toyoshi, Hozak, Pavel

“…This paper describes a novel type of nuclear structure - nuclear lipid islets (NLIs). They are of 40-100 nm with a lipidic interior, and phosphatidylinositol…”
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PIP2 epigenetically represses rRNA genes transcription interacting with PHF8 by Ulicna, Livia, Kalendova, Alzbeta, Kalasova, Ilona, Vacik, Tomas, Hozák, Pavel

“…Phosphoinositides are present in the plasma membrane, cytoplasm and inside the cell nucleus. Here we identify phosphatidylinositol-4,5-bisphosphate (PIP2) as a…”
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Corrigendum to “PIP2 epigenetically represses rRNA genes transcription interacting with PHF8” [Biochim. Biophys. Acta Mol. Cell Biol. Volume 1863/3 2017 266-275] by Ulicna, Livia, Kalendova, Alzbeta, Kalasova, Ilona, Vacik, Tomas, Hozák, Pavel

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The Interaction of SWI/SNF with the Ribosome Regulates Translation and Confers Sensitivity to Translation Pathway Inhibitors in Cancers with Complex Perturbations by Ulicna, Livia, Kimmey, Samuel C, Weber, Christopher M, Allard, Grace M, Wang, Aihui, Bui, Nam Q, Bendall, Sean C, Crabtree, Gerald R, Bean, Gregory R, Van Rechem, Capucine

“…Subunits from the chromatin remodelers mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) are mutated, deleted, or amplified in more than 40% of cancers…”
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Abstract 6586: ORIC-944, a potent and selective allosteric PRC2 inhibitor with best-in-class properties, demonstrates combination synergy with AR pathway inhibitors in prostate cancer models by Daemen, Anneleen, Yuen, Natalie, Wang, Amber, Pankov, Aleksandr, Ulicna, Livia, Chen, Chelsea, Duong, Frank L., Long, Jason, Marx, Matthew A., Christensen, James G., Friedman, Lori S., Junttila, Melissa R.

“…Polycomb repressive complex 2 (PRC2) dysregulation occurs in multiple tumor types and is associated with poor prognosis in patients with prostate cancer. In…”
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Abstract 594: ORIC-613, a potential first- and best-in-class, orally bioavailable, potent and selective PLK4 inhibitor with synthetic lethality in TRIM37 high cancer models by Edgar, Kyle A., McRee, Siobhan, Andretta, Gina, Chen, Chelsea, Colas, Christophe, Fang, Wei, Kong, Wayne, Long, Jason, Liu, Fang, Moore, Jared, Pankov, Aleskandr, Shore, Dan, Tan, Joanne, Warne, Robert, Ulicna, Livia, Vekariya, Rakesh, Daemen, Anneleen, Romero, F, Junttila, Melissa R., Friedman, Lori S.

“…A synthetic lethal interaction between polo-like kinase 4 (PLK4) and elevated TRIM37 was discovered in breast cancer and neuroblastoma (Meitinger et al. 2020;…”
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Abstract ND04: Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer by Marx, Matthew A., Burns, Aaron C., Arora, Nidhi, Bobinski, Thomas P., Briere, David M., Calinisan, Andrew, Gunn, Robin J., Ketcham, John M., Lawson, David, Lee, Matthew, Olson, Peter, Smith, Christopher R., Sudhakar, Niranjan, Christensen, James G., Chen, Chelsea X., Yuen, Natalie, Ulicna, Livia, Duong, Frank, Colas, Christophe, Ramnath, Anjana, Xu, Ron, Maneval, Edna Chow, Multani, Pratik S., Patel, Rupal, Kumar, Archana, Daemen, Anneleen, Romero, Anthony, Junttila, Melissa R., Friedman, Lori S.

“…First generation inhibitors of PRC2 (Polycomb Repressive Complex 2) targeting EZH2 (Enhancer of Zeste Homolog 2) achieved clinical proof-of-concept in…”
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Tools for visualization of phosphoinositides in the cell nucleus by Kalasova, Ilona, Fáberová, Veronika, Kalendová, Alžběta, Yildirim, Sukriye, Uličná, Lívia, Venit, Tomáš, Hozák, Pavel

“…Phosphoinositides (PIs) are glycerol-based phospholipids containing hydrophilic inositol ring. The inositol ring is mono-, bis-, or tris-phosphorylated…”
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Nuclear actin filaments recruit cofilin and actin-related protein 3, and their formation is connected with a mitotic block by Kalendová, Alžběta, Kalasová, Ilona, Yamazaki, Shota, Uličná, Lívia, Harata, Masahiko, Hozák, Pavel

“…Although actin monomers polymerize into filaments in the cytoplasm, the form of actin in the nucleus remains elusive. We searched for the form and function of…”
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Paxillin-dependent regulation of IGF2 and H19 gene cluster expression by Marášek, Pavel, Dzijak, Rastislav, Studenyak, Irina, Fišerová, Jindřiška, Uličná, Lívia, Novák, Petr, Hozák, Pavel

“…Paxillin (PXN) is a focal adhesion protein that has been implicated in signal transduction from the extracellular matrix. Recently, it has been shown to…”
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Nuclear Phosphoinositides-Versatile Regulators of Genome Functions by Castano, Enrique, Yildirim, Sukriye, Fáberová, Veronika, Krausová, Alžběta, Uličná, Lívia, Paprčková, Darina, Sztacho, Martin, Hozák, Pavel

“…The many functions of phosphoinositides in cytosolic signaling were extensively studied; however, their activities in the cell nucleus are much less clear. In…”
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