Search Results - "Uliasz, Tracy"
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Puberty Suppression Followed by Testosterone Therapy Does Not Impair Reproductive Potential in Female Mice
Published in Endocrinology (Philadelphia) (01-11-2023)“…Abstract More adolescents are coming out as transgender each year and are put on puberty blockers to suppress natal puberty, which is then followed by…”
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SNAP23 is required for constitutive and regulated exocytosis in mouse oocytes
Published in Biology of reproduction (01-08-2019)“…Mammalian oocytes are stored in the ovary for prolonged periods, and arrested in meiotic prophase. During this period, their plasma membranes are constantly…”
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Generation and Characterization of a TRIM21 Overexpressing Mouse Line
Published in Genesis (New York, N.Y. : 2000) (01-10-2024)“…Specific removal of a protein is a key to understanding its function. “Trim‐Away” utilizes TRIM21, an antibody receptor and ubiquitin ligase, for acute and…”
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Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase
Published in Biology of reproduction (13-01-2024)“…In response to luteinizing hormone (LH), multiple proteins in rat and mouse granulosa cells are rapidly dephosphorylated, but the responsible phosphatases…”
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The switch from cAMP-independent to cAMP-dependent arrest of meiotic prophase is associated with coordinated GPR3 and CDK1 expression in mouse oocytes
Published in Developmental biology (01-02-2018)“…Mammalian oocytes are arrested in meiotic prophase from around the time of birth until just before ovulation. Following an extended period of growth, they are…”
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Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes
Published in Development (Cambridge) (01-09-2014)“…In mammals, the meiotic cell cycle of oocytes starts during embryogenesis and then pauses. Much later, in preparation for fertilization, oocytes within…”
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Cyclic AMP links luteinizing hormone signaling to dephosphorylation and inactivation of the NPR2 guanylyl cyclase in ovarian follicles
Published in Biology of reproduction (01-05-2021)“…Summary sentence Cyclic AMP elevation links luteinizing hormone receptor signaling to dephosphorylation and inactivation of the NPR2 guanylyl cyclase in…”
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Multiple cAMP Phosphodiesterases Act Together to Prevent Premature Oocyte Meiosis and Ovulation
Published in Endocrinology (Philadelphia) (01-05-2018)“…Luteinizing hormone (LH) acts on the granulosa cells that surround the oocyte in mammalian preovulatory follicles to cause meiotic resumption and ovulation…”
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Cellular Heterogeneity of the Luteinizing Hormone Receptor and Its Significance for Cyclic GMP Signaling in Mouse Preovulatory Follicles
Published in Endocrinology (Philadelphia) (01-07-2020)“…Abstract Meiotic arrest and resumption in mammalian oocytes are regulated by 2 opposing signaling proteins in the cells of the surrounding follicle: the…”
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Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone
Published in Developmental biology (01-01-2016)“…The meiotic cell cycle of mammalian oocytes starts during embryogenesis and then pauses until luteinizing hormone (LH) acts on the granulosa cells of the…”
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Regulation of system x(c)(-)activity and expression in astrocytes by interleukin-1β: implications for hypoxic neuronal injury
Published in Glia (15-11-2010)“…We recently demonstrated that interleukin-1β (IL-1β) increases system x(c)(-) (cystine/glutamate antiporter) activity in mixed cortical cell cultures,…”
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Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells
Published in PloS one (27-06-2013)“…G protein-coupled receptor 3 (GPR3) is a constitutively active receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels required for…”
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Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis
Published in Biology of reproduction (01-05-2016)“…The meiotic cell cycle of mammalian oocytes in preovulatory follicles is held in prophase arrest by diffusion of cGMP from the surrounding granulosa cells into…”
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Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor
Published in eLife (04-12-2017)“…Activating mutations in fibroblast growth factor (FGF) receptor 3 and inactivating mutations in the NPR2 guanylyl cyclase both cause severe short stature, but…”
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Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases
Published in Frontiers in molecular neuroscience (19-10-2022)“…The natriuretic peptide receptors NPR1 and NPR2, also known as guanylyl cyclase A and guanylyl cyclase B, have critical functions in many signaling pathways,…”
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PGRMC1/2 promote luteal vascularization and maintain the primordial follicles of mice
Published in Reproduction (Cambridge, England) (01-08-2018)“…To determine whether conditional depletion of Progesterone Receptor Membrane Component (PGRMC) 1 and PGRMC2 affected ovarian follicle development, follicle…”
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Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs
Published in Development (Cambridge) (01-08-2015)“…During oocyte maturation, capacity and sensitivity of Ca(2+) signaling machinery increases dramatically, preparing the metaphase II (MII)-arrested egg for…”
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Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth
Published in JCI insight (10-05-2021)“…Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase…”
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Characterization of an improved procedure for the removal of microglia from confluent monolayers of primary astrocytes
Published in Journal of neuroscience methods (15-01-2006)“…Cultures of astrocytes can be readily established and are widely used to study the biological functions of these glial cells in isolation. Unfortunately,…”
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Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis1
Published in Biology of reproduction (01-05-2016)“…The meiotic cell cycle of mammalian oocytes in preovulatory follicles is held in prophase arrest by diffusion of cGMP from the surrounding granulosa cells into…”
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