Search Results - "Uliassi, Elisa"

The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment by Santucci, Matteo, Vignudelli, Tatiana, Ferrari, Stefania, Mor, Marco, Scalvini, Laura, Bolognesi, Maria Laura, Uliassi, Elisa, Costi, Maria Paola

“…The Hippo pathway is an important organ size control signaling network and the major regulatory mechanism of cell-contact inhibition. Yes associated protein…”
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A perspective on multi-target drug discovery and design for complex diseases by Ramsay, Rona R., Popovic-Nikolic, Marija R., Nikolic, Katarina, Uliassi, Elisa, Bolognesi, Maria Laura

“…Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative…”
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From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer's Disease? by Bolognesi, Maria Laura, Gandini, Annachiara, Prati, Federica, Uliassi, Elisa

“…The recent literature signals a growing paradigm shift toward integrating therapeutics and diagnostics rather than developing and deploying them separately. In…”
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Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease by Chalupova, Katarina, Korabecny, Jan, Bartolini, Manuela, Monti, Barbara, Lamba, Doriano, Caliandro, Rosanna, Pesaresi, Alessandro, Brazzolotto, Xavier, Gastellier, Anne-Julie, Nachon, Florian, Pejchal, Jaroslav, Jarosova, Michaela, Hepnarova, Vendula, Jun, Daniel, Hrabinova, Martina, Dolezal, Rafael, Zdarova Karasova, Jana, Mzik, Martin, Kristofikova, Zdena, Misik, Jan, Muckova, Lubica, Jost, Petr, Soukup, Ondrej, Benkova, Marketa, Setnicka, Vladimir, Habartova, Lucie, Chvojkova, Marketa, Kleteckova, Lenka, Vales, Karel, Mezeiova, Eva, Uliassi, Elisa, Valis, Martin, Nepovimova, Eugenie, Bolognesi, Maria Laura, Kuca, Kamil

“…A combination of tacrine and tryptophan led to the development of a new family of heterodimers as multi-target agents with potential to treat Alzheimer's…”
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Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer's Disease by Uliassi, Elisa, de Oliveira, Andressa Souza, de Camargo Nascente, Luciana, Romeiro, Luiz Antonio Soares, Bolognesi, Maria Laura

“…Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective…”
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The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy by Bianco, Maria da Conceição Avelino Dias, Inacio Leite, Debora, Silva Castelo Branco, Frederico, Boechat, Nubia, Uliassi, Elisa, Bolognesi, Maria Laura, Bastos, Monica Macedo

“…The concept of polypharmacology embraces multiple drugs combined in a therapeutic regimen (drug combination or cocktail), fixed dose combinations (FDCs), and a…”
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Structure-Based Design of 3‑(4-Aryl‑1H‑1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists by Junker, Anna, Balasubramanian, Ramachandran, Ciancetta, Antonella, Uliassi, Elisa, Kiselev, Evgeny, Martiriggiano, Chiara, Trujillo, Kevin, Mtchedlidze, Giorgi, Birdwell, Leah, Brown, Kyle A, Harden, T. Kendall, Jacobson, Kenneth A

“…UDP and UDP-glucose activate the P2Y14 receptor (P2Y14R) to modulate processes related to inflammation, diabetes, and asthma. A computational pipeline…”
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Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use by Lima, Clara M., Uliassi, Elisa, Thoré, Eli S.J., Bertram, Michael G., Cardoso, Luis, Cordeiro da Silva, Anabela, Costi, Maria Paola, de Koning, Harry P.

“…Background The current scientific discourse on environmental impacts of veterinary medicines mostly focuses on ectoparasiticides. Meanwhile, the environmental…”
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Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library by Lauriola, Angela, Uliassi, Elisa, Santucci, Matteo, Bolognesi, Maria Laura, Mor, Marco, Scalvini, Laura, Elisi, Gian Marco, Gozzi, Gaia, Tagliazucchi, Lorenzo, Marverti, Gaetano, Ferrari, Stefania, Losi, Lorena, D'Arca, Domenico, Costi, Maria Paola

“…The transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) are the major downstream effectors in…”
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Therapeutic strategies for identifying small molecules against prion diseases by Uliassi, Elisa, Nikolic, Lea, Bolognesi, Maria Laura, Legname, Giuseppe

“…Prion diseases are fatal neurodegenerative disorders, for which there are no effective therapeutic and diagnostic agents. The main pathological hallmark has…”
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Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One by Salerno, Alessandra, Seghetti, Francesca, Caciolla, Jessica, Uliassi, Elisa, Testi, Eleonora, Guardigni, Melissa, Roberti, Marinella, Milelli, Andrea, Bolognesi, Maria Laura

“…Proteolysis targeting chimera (PROTAC)-mediated protein degradation has prompted a radical rethink and is at a crucial stage in driving a drug discovery…”
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Click Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists? by Pasieka, Anna, Diamanti, Eleonora, Uliassi, Elisa, Laura Bolognesi, Maria

“…Click chemistry is universally recognized as a powerful strategy for the fast and precise assembly of diverse building blocks. Targeted Protein Degradation…”
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Harnessing the 12 Green Chemistry Principles for Sustainable Antiparasitic Drugs: Toward the One Health Approach by Martinengo, Bianca, Diamanti, Eleonora, Uliassi, Elisa, Bolognesi, Maria Laura

“…Antiparasitic drug development stands as a critical endeavor in combating infectious diseases which, by affecting the well-being of humans, animals, and the…”
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Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease by Uliassi, Elisa, Bergamini, Christian, Rizzardi, Nicola, Naldi, Marina, Cores, Ángel, Bartolini, Manuela, Carlos Menéndez, J., Bolognesi, Maria Laura

“…[Display omitted] •Novel multi-target-directed ligands (MTDLs) against Alzheimer's disease have been developed.•The new hybrids have been obtained by linking…”
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Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid‑β Aggregation and To Exert Anticholinesterase and Antioxidant Effects by Nepovimova, Eugenie, Uliassi, Elisa, Korabecny, Jan, Peña-Altamira, Luis Emiliano, Samez, Sarah, Pesaresi, Alessandro, Garcia, Gregory E, Bartolini, Manuela, Andrisano, Vincenza, Bergamini, Christian, Fato, Romana, Lamba, Doriano, Roberti, Marinella, Kuca, Kamil, Monti, Barbara, Bolognesi, Maria Laura

“…We report the identification of multitarget anti-Alzheimer compounds designed by combining a naphthoquinone function and a tacrine fragment. In vitro, 15…”
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Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease by Jeřábek, Jakub, Uliassi, Elisa, Guidotti, Laura, Korábečný, Jan, Soukup, Ondřej, Sepsova, Vendula, Hrabinova, Martina, Kuča, Kamil, Bartolini, Manuela, Peña-Altamira, Luis Emiliano, Petralla, Sabrina, Monti, Barbara, Roberti, Marinella, Bolognesi, Maria Laura

“…Multi-target drug discovery is one of the most followed approaches in the active central nervous system (CNS) therapeutic area, especially in the search for…”
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Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis by Exertier, Cécile, Salerno, Alessandra, Antonelli, Lorenzo, Fiorillo, Annarita, Ocello, Riccardo, Seghetti, Francesca, Caciolla, Jessica, Uliassi, Elisa, Masetti, Matteo, Fiorentino, Eleonora, Orsini, Stefania, Di Muccio, Trentina, Ilari, Andrea, Bolognesi, Maria Laura

“…Trypanothione reductase (TR) is a suitable target for drug discovery approaches against leishmaniasis, although the identification of potent inhibitors is…”
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Neuroregeneration versus neurodegeneration: toward a paradigm shift in Alzheimer's disease drug discovery by Uliassi, Elisa, Gandini, Annachiara, Perone, Rosaria Carmela, Bolognesi, Maria Laura

“…Alzheimer's disease represents an enormous global burden in terms of human suffering and economic cost. To tackle the current lack of effective drugs and the…”
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From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer’s Disease?: Miniperspective by Bolognesi, Maria Laura, Gandini, Annachiara, Prati, Federica, Uliassi, Elisa

“…The recent literature signals a growing paradigm shift toward integrating therapeutics and diagnostics rather than developing and deploying them separately. In…”
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PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer’s Disease by Guardigni, Melissa, Pruccoli, Letizia, Santini, Alan, Simone, Angela De, Bersani, Matteo, Spyrakis, Francesca, Frabetti, Flavia, Uliassi, Elisa, Andrisano, Vincenza, Pagliarani, Barbara, Fernández-Gómez, Paula, Palomo, Valle, Bolognesi, Maria Laura, Tarozzi, Andrea, Milelli, Andrea

“…Glycogen synthase kinase 3β (GSK-3β) is a serine/threonine kinase and an attractive therapeutic target for Alzheimer’s disease. Based on proteolysis-targeting…”
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