Search Results - "Uliana, Silvia R.B"

Identification of Leishmania (Viannia) species and clinical isolates of Leishmania (Leishmania) amazonensis from Brazil using PCR-RFLP of the heat-shock protein 70 gene reveals some unexpected observations by Espada, Caroline R., Ortiz, Paola A., Shaw, Jeffrey J., Barral, Aldina M.P., Costa, Jackson M.L., Uliana, Silvia R.B., Coelho, Adriano C.

“…Hsp70 is a cytoplasmic heat-shock protein, encoded by a multicopy tandemly repeated gene that has recently been gaining popularity as a valuable marker for…”
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Parasite burden in Leishmania (Leishmania) amazonensis-infected mice: Validation of luciferase as a quantitative tool by Reimão, Juliana Q., Trinconi, Cristiana T., Yokoyama-Yasunaka, Jenicer K., Miguel, Danilo C., Kalil, Sandra P., Uliana, Silvia R.B.

“…Given the lack of effective and safe alternatives to the drugs already in use, considerable efforts are being applied to the search of new therapeutic options…”
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Generation of luciferase-expressing Leishmania infantum chagasi and assessment of miltefosine efficacy in infected hamsters through bioimaging by Reimão, Juliana Q, Oliveira, Jordana C, Trinconi, Cristiana T, Cotrim, Paulo C, Coelho, Adriano C, Uliana, Silvia R B

“…The only oral drug available for the treatment of leishmaniasis is miltefosine, described and approved for visceral leishmaniasis in India. Miltefosine is…”
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In vitro and in vivo miltefosine susceptibility of a Leishmania amazonensis isolate from a patient with diffuse cutaneous leishmaniasis by Coelho, Adriano C, Trinconi, Cristiana T, Costa, Carlos H N, Uliana, Silvia R B

“…Miltefosine was the first oral compound approved for visceral leishmaniasis chemotherapy, and its efficacy against Leishmania donovani has been well…”
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Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania by Trinconi, Cristiana T., Miguel, Danilo C., Silber, Ariel M., Brown, Christopher, Mina, John G.M., Denny, Paul W., Heise, Norton, Uliana, Silvia R.B.

“…Previous work from our group showed that tamoxifen, an oral drug that has been in use for the treatment of breast cancer for over 40 years, is active both in…”
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Inhibitory activity of limonene against Leishmania parasites in vitro and in vivo by Arruda, Denise C, Miguel, Danilo C, Yokoyama-Yasunaka, Jenicer K.U, Katzin, Alejandro M, Uliana, Silvia R.B

“…Abstract Limonene is a monoterpene that has antitumoral, antibiotic and antiprotozoal activity. In this study we demonstrate the activity of limonene against…”
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Investigation of the pathways related to intrinsic miltefosine tolerance in Leishmania (Viannia) braziliensis clinical isolates reveals differences in drug uptake by Espada, Caroline R., Magalhães, Rubens M., Cruz, Mario C., Machado, Paulo R., Schriefer, Albert, Carvalho, Edgar M., Hornillos, Valentín, Alves, João M., Cruz, Angela K., Coelho, Adriano C., Uliana, Silvia R.B.

“…In Brazil, cutaneous leishmaniasis is caused predominantly by L. (V.) braziliensis. The few therapeutic drugs available exhibit several limitations, mainly…”
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Antileishmanial activity of the estrogen receptor modulator raloxifene by Reimão, Juliana Q, Miguel, Danilo C, Taniwaki, Noemi N, Trinconi, Cristiana T, Yokoyama-Yasunaka, Jenicer K U, Uliana, Silvia R B

“…The treatment of leishmaniasis relies mostly on parenteral drugs with potentially serious adverse effects. Additionally, parasite resistance in the treatment…”
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In vitro sensitivity of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis Brazilian isolates to meglumine antimoniate and amphotericin B by Zauli-Nascimento, Rogéria C, Miguel, Danilo C, Yokoyama-Yasunaka, Jenicer K.U, Pereira, Ledice I.A, Pelli de Oliveira, Milton A, Ribeiro-Dias, Fátima, Dorta, Miriam L, Uliana, Silvia R.B

“…Resistance of Leishmania parasites to specific chemotherapy has become a well-documented problem in the Indian subcontinent in recent years but only a few…”
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Leishmania is not prone to develop resistance to tamoxifen by Coelho, Adriano C., Trinconi, Cristiana T., Senra, Luisa, Yokoyama-Yasunaka, Jenicer K.U., Uliana, Silvia R.B.

“…Tamoxifen, an antineoplastic agent, is active in vitro and in vivo against the parasitic protozoa Leishmania. As part of our efforts to unravel this drug's…”
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Clinical isolates of New World Leishmania from cutaneous and visceral leishmaniasis patients are uniformly sensitive to tamoxifen by Miguel, Danilo C, Zauli-Nascimento, Rogéria C, Yokoyama-Yasunaka, Jenicer K.U, Pereira, Ledice I.A, Jerônimo, Selma M.B, Ribeiro-Dias, Fátima, Dorta, Miriam L, Uliana, Silvia R.B

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Leishmania amazonensis META2 protein confers protection against heat shock and oxidative stress by Ramos, Camila S., Yokoyama-Yasunaka, Jenicer K.U., Guerra-Giraldez, Cristina, Price, Helen P., Mortara, Renato A., Smith, Deborah F., Uliana, Silvia R.B.

“…[Display omitted] ► Leishmania amazonensis META2 protein expression and localisation is stage-regulated. ► META2-null mutants are viable but hypersensitive to…”
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The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice by Miguel, Danilo Ciccone, Ferraz, Marcela Lencine, de Oliveira Alves, Rosana, Yokoyama-Yasunaka, Jenicer K.U, Torrecilhas, Ana Claudia, Romanha, Alvaro José, Uliana, Silvia R.B

“…The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi . In vitro activity was determined against epimastigote,…”
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Chemotherapy of leishmaniasis: present challenges by Uliana, Silvia R B, Trinconi, Cristiana T, Coelho, Adriano C

“…Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases of our time, affecting millions of people worldwide. The treatment of…”
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Cellular infiltrate in cutaneous leishmaniasis lesions and therapeutic outcome by Ribeiro, Camila Sampaio, França, Riam Rocha, Silva, Juliana Almeida, Silva, Silvana Conceição da, Uliana, Sílvia R.B., Boaventura, Viviane Sampaio, Machado, Paulo R.L.

“…The treatment of cutaneous leishmaniasis is a challenge. A better understanding of the in situ mechanisms involved in the evolution and cure of the disease is…”
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Efficacy of tamoxifen and miltefosine combined therapy for cutaneous leishmaniasis in the murine model of infection with Leishmania amazonensis by Trinconi, Cristiana T, Reimão, Juliana Q, Coelho, Adriano C, Uliana, Silvia R B

“…The objective of this study was to characterize in vitro interactions and evaluate the antileishmanial activity of tamoxifen and miltefosine combinations…”
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Full nucleotide sequencing of ribosomal DNA internal transcribed spacer of Leishmania species causing cutaneous leishmaniasis in Brazil and its potential for species typing by Espada, Caroline R., Ferreira, Bianca A., Ortiz, Paola A., Uliana, Silvia R.B., Coelho, Adriano C.

“…•The full nucleotide sequences of the ribosomal ITS1, 5.8 S and ITS2 of Leishmania (Viannia) lainsoni, L. (V.) lindenbergi L. (V.) naiffi, L. (V.) shawi and L…”
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Topical tamoxifen in the therapy of cutaneous leishmaniasis by Trinconi, Cristiana T, Reimão, Juliana Q, Bonano, Vivian I, Espada, Caroline R, Miguel, Danilo C, Yokoyama-Yasunaka, Jenicer K U, Uliana, Silvia R B

“…The aims of the present work were to test the effect of tamoxifen administered topically and the therapeutic efficacy of tamoxifen and pentavalent antimonial…”
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Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model by Agostino, Victor S., Trinconi, Cristiana M., Galuppo, Mariana K., Price, Helen, Uliana, Silvia R.B.

“…•Luciferase expression did not interfere in in vitro fitness of parasites.•Intracellular amastigote viability was reliably detected through NLP, RL and…”
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Combination Therapy with Tamoxifen and Amphotericin B in Experimental Cutaneous Leishmaniasis by TRINCONI, Cristiana T, REIMAO, Juliana Q, YOKOYAMA-YASUNAKA, Jenicer K. U, MIGUEL, Danilo C, ULIANA, Silvia R. B

“…Leishmaniasis chemotherapy remains very challenging. The high cost of active drugs, along with the severity of their side effects and the increasing failure…”
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