Search Results - "Ulfendahl, Mats"

Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation by Hellström, Anders R, Watt, Brenda, Fard, Shahrzad Shirazi, Tenza, Danièle, Mannström, Paula, Narfström, Kristina, Ekesten, Björn, Ito, Shosuke, Wakamatsu, Kazumasa, Larsson, Jimmy, Ulfendahl, Mats, Kullander, Klas, Raposo, Graça, Kerje, Susanne, Hallböök, Finn, Marks, Michael S, Andersson, Leif

“…PMEL is an amyloidogenic protein that appears to be exclusively expressed in pigment cells and forms intralumenal fibrils within early stage melanosomes upon…”
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The potential of stem cells for the restoration of auditory function in humans by Hu, Zhengqing, Ulfendahl, Mats

“…Hearing loss is one of the most common disabilities, affecting approximately 10% of the population. Hair cells and spiral ganglion neurons are usually damaged…”
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Dietary restriction reduces age-related degeneration of stria vascularis in the inner ear of the rat by Mannström, Paula, Ulfhake, Brun, Kirkegaard, Mette, Ulfendahl, Mats

“…We report here beneficial effects of life-long dietary restriction on the progression of age-associated cochlear degeneration in female Sprague–Dawley rats…”
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The chorda tympani degenerates during chronic otitis media: an electron microscopy study by Berling, Katarina, Mannström, Paula, Ulfendahl, Mats, Danckwardt Lillieström, Niklas, von Unge, Magnus

“…AbstractConclusion: Chorda tympani nerve specimens from ears with chronic inflammatory middle ear disease exhibit structural signs of degeneration. These…”
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Glial cell line-derived neurotrophic factor and antioxidants preserve the electrical responsiveness of the spiral ganglion neurons after experimentally induced deafness by Maruyama, Jun, Miller, Josef M, Ulfendahl, Mats

“…Abstract Cochlear implant surgery is currently the therapy of choice for profoundly deaf patients. However, the functionality of cochlear implants depends on…”
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Imaging Hair Cell Transduction at the Speed of Sound: Dynamic Behavior of Mammalian Stereocilia by Fridberger, Anders, Tomo, Igor, Ulfendahl, Mats, de Monvel, Jacques Boutet

“…The cochlea contains two types of sensory cells, the inner and outer hair cells. Sound-evoked deflection of outer hair cell stereocilia leads to fast force…”
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Neurotrophic Factor Intervention Restores Auditory Function in Deafened Animals by Shinohara, Takayuki, Bredberg, Göran, Ulfendahl, Mats, Pyykkö, Ilmari, Olivius, N. Petri, Kaksonen, Risto, Lindström, Bo, Altschuler, Richard, Miller, Josef M.

“…A primary cause of deafness is damage of receptor cells in the inner ear. Clinically, it has been demonstrated that effective functionality can be provided by…”
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Central migration of neuronal tissue and embryonic stem cells following transplantation along the adult auditory nerve by Hu, Zhengqing, Ulfendahl, Mats, Olivius, N. Petri

“…The regeneration of the auditory nerve remains a challenge in restoring hearing. An interesting approach would be to use a cell replacement therapy with the…”
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Survival, synaptogenesis, and regeneration of adult mouse spiral ganglion neurons in vitro by Wei, Dongguang, Jin, Zhe, Järlebark, Leif, Scarfone, Eric, Ulfendahl, Mats

“…The inner ear spiral ganglion is populated by bipolar neurons connecting the peripheral sensory receptors, the hair cells, with central neurons in auditory…”
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Activation of JNK in the inner ear following impulse noise exposure by Murai, Norihiko, Kirkegaard, Mette, Järlebark, Leif, Risling, Mårten, Suneson, Anders, Ulfendahl, Mats

“…Noise exposure is known to induce cell death signaling in the cochlea. Since c-Jun N-terminal kinase (JNK) signaling is known to induce both cell survival and…”
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A database on global health research in Africa by Collins, Francis, Beaudet, Alain, Draghia-Akli, Ruxandra, Gruss, Peter, Savill, John, Syrota, André, Dautry, Alice, Ulfendahl, Mats, Walport, Mark, Onken, James, Glass, Roger I

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Neural cograft stimulates the survival and differentiation of embryonic stem cells in the adult mammalian auditory system by Hu, Zhengqing, Andäng, Michael, Ni, Daofeng, Ulfendahl, Mats

“…Mouse embryonic stem (ES) cells were transplanted into the cochlea of adult guinea pigs in order to explore their survival, differentiation, and possible…”
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Delayed neurotrophic treatment preserves nerve survival and electrophysiological responsiveness in neomycin-deafened guinea pigs by Yamagata, Takahiko, Miller, Josef M., Ulfendahl, Mats, Olivius, N. Petri, Altschuler, Richard A., Pyykkö, Ilmari, Bredberg, Göran

“…Benefits of cochlear prostheses for the deaf are dependent on survival and excitability of the auditory nerve. Degeneration of deafferented auditory nerve…”
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Functional evaluation of a cell replacement therapy in the inner ear by Hu, Zhengqing, Ulfendahl, Mats, Prieskorn, Diane M, Olivius, Petri, Miller, Josef M

“…Cell replacement therapy in the inner ear will contribute to the functional recovery of hearing loss. Cell replacement therapy is a potentially powerful…”
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Signaling through erbB receptors is a critical functional regulator in the mature cochlea by Watanabe, Futoshi, Kirkegaard, Mette, Matsumoto, Suguru, Gont, Cecilia, Mannström, Paula, Ulfendahl, Mats, Fridberger, Anders

“…Noise, ototoxic substances and various genetic factors are common causes of profound hearing loss. Cochlear implants can often restore hearing in these cases,…”
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NGF stimulates extensive neurite outgrowth from implanted dorsal root ganglion neurons following transplantation into the adult rat inner ear by Hu, Zhengqing, Ulfendahl, Mats, Petri Olivius, N.

“…Neuronal tissue transplantation is a potential way to replace degenerated spiral ganglion neurons (SGNs) since these cells cannot regenerate in adult mammals…”
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Effect of auditory stress agents on heterozygous German waltzing guinea pigs by Skjönsberg, Åsa, Duan, Maoli, Johnson, Ann-Christin, Ulfendahl, Mats

“…The German waltzing guinea pig is a strain of animals expressing deafness and severe balance disorders at birth.The mutation arose spontaneously in a breeding…”
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Acoustic Overstimulation Increases Outer Hair Cell Ca2+Concentrations and Causes Dynamic Contractions of the Hearing Organ by Fridberger, Anders, Flock, Ake, Ulfendahl, Mats, Flock, Britta

“…The dynamic responses of the hearing organ to acoustic overstimulation were investigated using the guinea pig isolated temporal bone preparation. The organ was…”
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Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs by Maruyama, Jun, Yamagata, Takahiko, Ulfendahl, Mats, Bredberg, Göran, Altschuler, Richard A, Miller, Josef M

“…Abstract Based on in vitro studies, it is hypothesized that neurotrophic factor deprivation following deafferentation elicits an oxidative state change in the…”
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Membrane cholesterol modulates cochlear electromechanics by Brownell, William E., Jacob, Stefan, Hakizimana, Pierre, Ulfendahl, Mats, Fridberger, Anders

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