Search Results - "Ulevitch, Richard"

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component by Shi, Hexin, Wang, Ying, Li, Xiaohong, Zhan, Xiaoming, Tang, Miao, Fina, Maggy, Su, Lijing, Pratt, David, Bu, Chun Hui, Hildebrand, Sara, Lyon, Stephen, Scott, Lindsay, Quan, Jiexia, Sun, Qihua, Russell, Jamie, Arnett, Stephanie, Jurek, Peter, Chen, Ding, Kravchenko, Vladimir V, Mathison, John C, Moresco, Eva Marie Y, Monson, Nancy L, Ulevitch, Richard J, Beutler, Bruce

“…NEK7 is a serine-threonine kinase linked to mitosis. Beutler and colleagues show that NEK7 is required for assembly of the NLRP3 inflammasome and restricts…”
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Therapeutics targeting the innate immune system by Ulevitch, Richard J

“…Proteins that recognize the components and products of microorganisms have an important role in innate immunity. Here, I focus on recent advances in our…”
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Limiting inflammatory responses during activation of innate immunity by Han, Jiahuai, Ulevitch, Richard J

“…The idea of the importance of mounting an inflammatory response for effective immunity is supported by a multiplicity of experimental data. It is also well…”
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Toll-like receptors in the induction of the innate immune response by Aderem, Alan, Ulevitch, Richard J

“…The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a…”
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An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury by Shigeoka, Alana A, Mueller, James L, Kambo, Amanpreet, Mathison, John C, King, Andrew J, Hall, Wesley F, Correia, Jean da Silva, Ulevitch, Richard J, Hoffman, Hal M, McKay, Dianne B

“…Cytoplasmic innate immune receptors are important therapeutic targets for diseases associated with overproduction of proinflammatory cytokines. One cytoplasmic…”
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Targeting innate immunity by blocking CD14: Novel approach to control inflammation and organ dysfunction in COVID-19 illness by Martin, Thomas R., Wurfel, Mark M., Zanoni, Ivan, Ulevitch, Richard

“…The SARS-CoV-2 pandemic has produced an unprecedented rush to develop new therapies, ranging from immunizations and antivirals to host-directed therapies to…”
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Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors by Ulevitch, Richard J, Chuang, Tsung-Hsien

“…Activation of Toll-like receptors (TLRs) results in a proinflammatory response needed to combat infection. Thus, limiting TLR signaling is essential for…”
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NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice by Zhang, Peipei, Liu, Yifei, Hu, Lichen, Huang, Kai, Hong, Mao, Wang, Yuze, Fan, Xinrui, Ulevitch, Richard J, Han, Jiahuai

“…Inflammasome is an innate immune defense mechanism, but its overactivation can lead to host death. Here, we show that cell death dictates mouse death caused by…”
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Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice by Green, Douglas R, Nicholson, Donald W, Saleh, Maya, Mathison, John C, Wolinski, Melissa K, Bensinger, Steve J, Fitzgerald, Patrick, Droin, Nathalie, Ulevitch, Richard J

“…Caspases function in both apoptosis and inflammatory cytokine processing and thereby have a role in resistance to sepsis. Here we describe a novel role for a…”
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Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones by Rayo, Josep, Gregor, Rachel, Jacob, Nicholas T., Dandela, Rambabu, Dubinsky, Luba, Yashkin, Alex, Aranovich, Alexander, Thangaraj, Manikandan, Ernst, Orna, Barash, Eran, Malitsky, Sergey, Florea, Bogdan I., Krom, Bastiaan P., Wiemer, Erik A. C., Kickhoefer, Valerie A., Rome, Leonard H., Mathison, John C., Kaufmann, Gunnar F., Overkleeft, Herman S., Cravatt, Benjamin F., Zor, Tsaffrir, Janda, Kim D., Ulevitch, Richard J., Kravchenko, Vladimir V., Meijler, Michael M.

“…The major vault protein (MVP) mediates diverse cellular responses, including cancer cell resistance to chemotherapy and protection against inflammatory…”
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Modulation of Gene Expression via Disruption of NF-κB Signaling by a Bacterial Small Molecule by Kravchenko, Vladimir V, Kaufmann, Gunnar F, Mathison, John C, Scott, David A, Katz, Alexander Z, Grauer, David C, Lehmann, Mandy, Meijler, Michael M, Janda, Kim D, Ulevitch, Richard J

“…The control of innate immune responses through activation of the nuclear transcription factor NF-κB is essential for the elimination of invading microbial…”
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SGT1 is essential for Nod1 activation by da Silva Correia, Jean, Miranda, Yvonne, Leonard, Nikki, Ulevitch, Richard

“…The Nod-like receptor family in man contains proteins that recognize invasive bacteria. Nod1, a member of this family, is activated by specific…”
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Nod1 and Nod2 Are Expressed in Human and Murine Renal Tubular Epithelial Cells and Participate in Renal Ischemia Reperfusion Injury by Shigeoka, Alana A, Kambo, Amanpreet, Mathison, John C, King, Andrew J, Hall, Wesley F, da Silva Correia, Jean, Ulevitch, Richard J, McKay, Dianne B

“…Nucleotide-binding oligomerization domain (Nod) 1 and Nod2 are members of a family of intracellular innate sensors that participate in innate immune responses…”
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MD-2 and TLR4 N-Linked Glycosylations Are Important for a Functional Lipopolysaccharide Receptor by da Silva Correia, Jean, Ulevitch, Richard J.

“…The lipopolysaccharide (LPS) receptor is a multi-protein complex that consists of at least three proteins, CD14, TLR4, and MD-2. Because each of these proteins…”
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Lack of Both Nucleotide-Binding Oligomerization Domain-Containing Proteins 1 and 2 Primes T Cells for Activation-Induced Cell Death by Kasimsetty, Sashi G, Shigeoka, Alana A, Scheinok, Andrew A, Gavin, Amanda L, Ulevitch, Richard J, McKay, Dianne B

“…Nucleotide-binding oligomerization domain (Nod)-containing proteins Nod1 and Nod2 play important roles in the innate immune response to pathogenic microbes,…”
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MDP-induced interleukin-1β processing requires Nod2 and CIAS1/NALP3 by Pan, Qilin, Mathison, John, Fearns, Colleen, Kravchenko, Vladimir V., Da Silva Correia, Jean, Hoffman, Hal M., Kobayashi, Koichi S., Bertin, John, Grant, Ethan P., Coyle, Anthony J., Sutterwala, Fayyaz S., Ogura, Yasunori, Flavell, Richard A., Ulevitch, Richard J.

“…Nucleotide‐binding oligomerization domain (Nod)2 is a sensor of muramyl dipeptides (MDP) derived from bacterial peptidoglycan. Nod2 also plays a role in some…”
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MAPKK-Independent Activation of p38α Mediated by TAB1-Dependent Autophosphorylation of p38α by Ge, Baoxue, Gram, Hermann, Di Padova, Franco, Huang, Betty, New, Liguo, Ulevitch, Richard J., Luo, Ying, Han, Jiahuai

“…Phosphorylation of mitogen-activated protein kinases (MAPKs) on specific tyrosine and threonine sites by MAP kinase kinases (MAPKKs) is thought to be the sole…”
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A Synthetic TLR4 Antagonist Has Anti-Inflammatory Effects in Two Murine Models of Inflammatory Bowel Disease by Fort, Madeline M, Mozaffarian, Afsaneh, Stover, Axel G, Correia, Jean da Silva, Johnson, David A, Crane, R. Thomas, Ulevitch, Richard J, Persing, David H, Bielefeldt-Ohmann, Helle, Probst, Peter, Jeffery, Eric, Fling, Steven P, Hershberg, Robert M

“…Current evidence indicates that the chronic inflammation observed in the intestines of patients with inflammatory bowel disease is due to an aberrant immune…”
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Recognition of Gram-negative bacteria and endotoxin by the innate immune system by Ulevitch, Richard J, Tobias, Peter S

“…Until about 10 years ago the exact mechanisms controlling cellular responses to the endotoxin – or lipopolysaccharide (LPS) – of Gram-negative bacteria were…”
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Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4 by Raetz, Christian R.H., Garrett, Teresa A., Reynolds, C. Michael, Shaw, Walter A., Moore, Jeff D., Smith, Dale C., Ribeiro, Anthony A., Murphy, Robert C., Ulevitch, Richard J., Fearns, Colleen, Reichart, Donna, Glass, Christopher K., Benner, Chris, Subramaniam, Shankar, Harkewicz, Richard, Bowers-Gentry, Rebecca C., Buczynski, Matthew W., Cooper, Jennifer A., Deems, Raymond A., Dennis, Edward A.

“…The LIPID MAPS Consortium (www.lipidmaps.org) is developing comprehensive procedures for identifying all lipids of the macrophage, following activation by…”
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