Search Results - "Ulaeto, David"

APOBEC3 deaminase editing in mpox virus as evidence for sustained human transmission since at least 2016 by O'Toole, Áine, Neher, Richard A, Ndodo, Nnaemeka, Borges, Vitor, Gannon, Ben, Gomes, João Paulo, Groves, Natalie, King, David J, Maloney, Daniel, Lemey, Philippe, Lewandowski, Kuiama, Loman, Nicholas, Myers, Richard, Omah, Ifeanyi F, Suchard, Marc A, Worobey, Michael, Chand, Meera, Ihekweazu, Chikwe, Ulaeto, David, Adetifa, Ifedayo, Rambaut, Andrew

“…Historically, mpox has been characterized as an endemic zoonotic disease that transmits through contact with the reservoir rodent host in West and Central…”
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Poxin-deficient poxviruses are sensed by cGAS prior to genome replication by Lant, Sian, Hood, Alasdair J M, Holley, Joe A, Ellis, Ailish, Eke, Lucy, Sumner, Rebecca P, Ulaeto, David O, Maluquer de Motes, Carlos

“…Poxviruses are dsDNA viruses infecting a wide range of cell types, where they need to contend with multiple host antiviral pathways, including DNA and RNA…”
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Distinct monkeypox virus lineages co-circulating in humans before 2022 by Ndodo, Nnaemeka, Ashcroft, Jonathan, Lewandowski, Kuiama, Yinka-Ogunleye, Adesola, Chukwu, Chimaobi, Ahmad, Adama, King, David, Akinpelu, Afolabi, Maluquer de Motes, Carlos, Ribeca, Paolo, Sumner, Rebecca P., Rambaut, Andrew, Chester, Michael, Maishman, Tom, Bamidele, Oluwafemi, Mba, Nwando, Babatunde, Olajumoke, Aruna, Olusola, Pullan, Steven T., Gannon, Benedict, Brown, Colin S., Ihekweazu, Chikwe, Adetifa, Ifedayo, Ulaeto, David O.

“…The 2022 global mpox outbreak raises questions about how this zoonotic disease established effective human-to-human transmission and its potential for further…”
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Evolutionary implications of human transmission of monkeypox: the importance of sequencing multiple lesions by Ulaeto, David O, Dunning, Jake, Carroll, Miles W

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A prototype lateral flow assay for detection of orthopoxviruses by Ulaeto, David O, Lonsdale, Steve G, Laidlaw, Stephen M, Clark, Graeme C, Horby, Peter, Carroll, Miles W

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Protection of Mice from Lethal Vaccinia Virus Infection by Vaccinia Virus Protein Subunits with a CpG Adjuvant by Reeman, Sarah, Gates, Amanda J, Pulford, David J, Krieg, Art, Ulaeto, David O

“…Smallpox vaccination carries a high risk of adverse events in recipients with a variety of contra-indications for live vaccines. Although alternative…”
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Pegylation of Antimicrobial Peptides Maintains the Active Peptide Conformation, Model Membrane Interactions, and Antimicrobial Activity while Improving Lung Tissue Biocompatibility following Airway Delivery by Morris, Christopher J, Beck, Konrad, Fox, Marc A, Ulaeto, David, Clark, Graeme C, Gumbleton, Mark

“…Antimicrobial peptides (AMPs) have therapeutic potential, particularly for localized infections such as those of the lung. Here we show that airway…”
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Destabilization of α-Helical Structure in Solution Improves Bactericidal Activity of Antimicrobial Peptides: Opposite Effects on Bacterial and Viral Targets by Ulaeto, David O, Morris, Christopher J, Fox, Marc A, Gumbleton, Mark, Beck, Konrad

“…We have previously examined the mechanism of antimicrobial peptides on the outer membrane of vaccinia virus. We show here that the formulation of peptides LL37…”
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Design and characterization of novel hybrid antimicrobial peptides based on cecropin A, LL-37 and magainin II by Fox, Marc A., Thwaite, Joanne E., Ulaeto, David O., Atkins, Timothy P., Atkins, Helen S.

“…► Rational design of hybrid peptides from natural parents. ► Direct antimicrobial activity improved over parents. ► Activity against Bacillus anthracis,…”
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Aerosol infection of Balb/c mice with eastern equine encephalitis virus; susceptibility and lethality by Phelps, Amanda L, O'Brien, Lyn M, Eastaugh, Lin S, Davies, Carwyn, Lever, Mark S, Ennis, Jane, Zeitlin, Larry, Nunez, Alejandro, Ulaeto, David O

“…Eastern equine encephalitis virus is an alphavirus that naturally cycles between mosquitoes and birds or rodents in Eastern States of the US. Equine infection…”
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Accelerating Genetic Sensor Development, Scale-up, and Deployment Using Synthetic Biology by Joshi, Shivang Hina-Nilesh, Jenkins, Christopher, Ulaeto, David, Gorochowski, Thomas E

“…Living cells are exquisitely tuned to sense and respond to changes in their environment. Repurposing these systems to create engineered biosensors has seen…”
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Cross-Strain Neutralizing and Protective Monoclonal Antibodies against EEEV or WEEV by Phelps, Amanda L, O'Brien, Lyn M, Ulaeto, David O, Holtsberg, Frederick W, Liao, Grant C, Douglas, Robin, Aman, M Javad, Glass, Pamela J, Moyer, Crystal L, Ennis, Jane, Zeitlin, Larry, Nagata, Les P, Hu, Wei-Gang

“…The three encephalitic alphaviruses, namely, the Venezuelan, eastern, and western equine encephalitis viruses (VEEV, EEEV, and WEEV), are classified by the…”
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Evaluation of the SARS-CoV-2 Inactivation Efficacy Associated With Buffers From Three Kits Used on High-Throughput RNA Extraction Platforms by Thom, Ruth E, Eastaugh, Lin S, O'Brien, Lyn M, Ulaeto, David O, Findlay, James S, Smither, Sophie J, Phelps, Amanda L, Stapleton, Helen L, Hamblin, Karleigh A, Weller, Simon A

“…Rapid and demonstrable inactivation of SARS-CoV-2 is crucial to ensure operator safety during high-throughput testing of clinical samples. The inactivation…”
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Susceptibility and Lethality of Western Equine Encephalitis Virus in Balb/c Mice When Infected by the Aerosol Route by Phelps, Amanda L, O'Brien, Lyn M, Eastaugh, Lin S, Davies, Carwyn, Lever, Mark S, Ennis, Jane, Zeitlin, Larry, Nunez, Alejandro, Ulaeto, David O

“…Western equine encephalitis virus (WEEV) naturally cycles between mosquitos and birds or rodents, with a case fatality rate of up to 15% in humans during…”
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Corrigendum: Evaluation of the SARS-CoV-2 Inactivation Efficacy Associated With Buffers From Three Kits Used on High-Throughput RNA Extraction Platforms by Thom, Ruth E, Eastaugh, Lin S, O'Brien, Lyn M, Ulaeto, David O, Findlay, James S, Smither, Sophie J, Phelps, Amanda L, Stapleton, Helen L, Hamblin, Karleigh A, Weller, Simon A

“…[This corrects the article DOI: 10.3389/fcimb.2021.716436.]…”
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Sub-Nanogram Detection of RDX Explosive by Monoclonal Antibodies by Ulaeto, David O, Hutchinson, Alistair P, Nicklin, Stephen

“…Polyclonal and monoclonal antibodies were raised to protein carrier molecules haptenized with RDX, a major component of many plastic explosives including…”
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Assessment of antimicrobial peptide LL-37 as a post-exposure therapy to protect against respiratory tularemia in mice by Flick-Smith, Helen C., Fox, Marc A., Hamblin, Karleigh A., Richards, Mark I., Jenner, Dominic C., Laws, Thomas R., Phelps, Amanda L., Taylor, Christopher, Harding, Sarah V., Ulaeto, David O., Atkins, Helen S.

“…•The utility of nasally delivered LL-37 as a post-exposure therapy for tularaemia in mice was examined.•Significant reduction in bacterial growth was seen in…”
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The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains by Thwaite, Joanne E, Humphrey, Suzanne, Fox, Marc A, Savage, Victoria L, Laws, Thomas R, Ulaeto, David O, Titball, Richard W, Atkins, Helen S

“…1 Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK 2 School of Biosciences, Geoffrey Pope Building, University of Exeter, Exeter…”
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New nomenclature for mpox (monkeypox) and monkeypox virus clades by Ulaeto, David, Agafonov, Alexander, Burchfield, Jennifer, Carter, Lisa, Happi, Christian, Jakob, Robert, Krpelanova, Eva, Kuppalli, Krutika, Lefkowitz, Elliot J, Mauldin, Matthew R, de Oliveira, Tulio, Onoja, Bernard, Otieno, James, Rambaut, Andrew, Subissi, Lorenzo, Yinka-Ogunleye, Adesola, Lewis, Rosamund F

“…The Director-General of WHO called on member states to ensure respect for human rights and to address stigma and discrimination.3 As of Jan 31, 2023, there…”
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Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus by Lello, Laura Sandra, Miilimäe, Agneta, Cherkashchenko, Liubov, Omler, Ailar, Skilton, Rachel, Ireland, Rachel, Ulaeto, David, Merits, Andres

“…Eastern equine encephalitis virus (EEEV) usually cycles between Culiseta melanura mosquitoes and birds; however, it can also infect humans. EEEV has a…”
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