Search Results - "Ukai, Yojiro"

Determination and Bioimaging Method for Nitric Oxide in Biological Specimens by Diaminofluorescein Fluorometry by Itoh, Yoshinori, Ma, Fu Hai, Hoshi, Hanae, Oka, Michiko, Noda, Kumiko, Ukai, Yojiro, Kojima, Hirotatsu, Nagano, Tetsuo, Toda, Noboru

“…A simple and sensitive assay and a cellular bioimaging method for nitric oxide (NO) were developed using a novel diaminofluorescein DAF-FM and its diacetate…”
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Phosphodiesterase Type IV Inhibitors Prevent Ischemia-Reperfusion-Induced Gastric Injury in Rats by Kyoi, Takashi, Kitazawa, Satoru, Tajima, Koyuki, Zhang, Xin, Ukai, Yojiro

“…The effects of selective inhibitors of phosphodiesterase type IV (PDE4) on ischemia-reperfusion-induced gastric injuries were investigated in rats. Gastric…”
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Irsogladine Prevents Monochloramine-Induced Gastric Mucosal Lesions by Improving the Decrease in Mucosal Blood Flow Due to the Disturbance of Nitric Oxide Synthesis in Rats by Kyoi, Takashi, Oka, Michiko, Noda, Kumiko, Ukai, Yojiro

“…The inhibitory effect of an anti-ulcer drug irsogladine [2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate] on monochloramine (NH2Cl)-induced gastric…”
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Phosphodiesterase inhibition by a gastroprotective agent irsogladine: Preferential blockade of cAMP hydrolysis by Kyoi, Takashi, Oka, Michiko, Noda, Kumiko, Ukai, Yojiro

“…The effect of irsogladine [2,4-diamino-6-(2,5-dichlorophenyl)- s-triazine maleate], an antiulcer drug, on contents of cyclic nucleotides including cAMP and…”
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Involvement of peroxynitrite and hydroxyradical generated from nitric oxide in hypoxia/reoxygenation injury in rat cerebrocortical slices by Oka, Michiko, Hirouchi, Masaaki, Itoh, Yoshinori, Ukai, Yojiro

“…The changes in nitric oxide (NO) formation during hypoxia and reoxygenation were measured in slices of rat cerebral cortex, and the possible involvement of NO…”
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Blockade by NS‐7, a Neuroprotective Compound, of Both L‐Type and P/Q‐Type Ca2+ Channels Involving Depolarization‐Stimulated Nitric Oxide Synthase Activity in Primary Neuronal Culture by Oka, Michiko, Itoh, Yoshinori, Ukai, Yojiro, Kimura, Kiyoshi

“…: The effect of 4‐(4‐fluorophenyl)‐2‐methyl‐6‐(5‐piperidinopentyloxy)pyrimidine hydrochloride (NS‐7), a neuroprotective compound, on Ca2+ channels involving…”
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Current state on development of neuroprotective agents for cerebral ischemia by Hirouchi, Masaaki, Ukai, Yojiro

“…The improvement of decreased cerebral blood flow using thrombolytic agents, anti-thrombin drugs, and antiplatelet drugs has been essential for acute ischemic…”
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Functional role of inhibitory and excitatory nerves in the porcine lower urinary tract by Noda, Kumiko, Takebe, Mika, Oka, Michiko, Hirouchi, Masaaki, Ukai, Yojiro, Toda, Noboru

“…In the trigone (three portions) and proximal urethra isolated from castrated male pigs, transmural electrical stimulation (0.5–10 Hz) induced no or slight…”
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Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7 by Aoki, Yasuaki, Tamura, Masaru, Itoh, Yoshinori, Ukai, Yojiro

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Irsogladine Prevents Monochloramine-Induced Gastric Mucosal Lesions by Improving the Decrease in Mucosal Blood Flow Due to the Disturbance of Nitric Oxide Synthesis in Rats by Kyoi, Takashi, Oka, Michiko, Noda, Kumiko, Ukai, Yojiro

“…The inhibitory effect of an anti-ulcer drug irsogladine [2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate] on monochloramine (NH2Cl)-induced gastric…”
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Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats by Tachibana, Masaki, Inoue, Naoki, Yoshida, Eri, Matsui, Masami, Ukai, Yojiro, Yano, Junichi

“…Adjuvant arthritic rats are known to be more susceptible to gastric damage induced by non-steroidal anti-inflammatory drugs (NSAIDs) than are normal rats. We…”
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Cerebroprotective action of a Na+/Ca2+ channel blocker NS-7 by Tamura, Masaru, Aoki, Yasuaki, Seto, Toshie, Itoh, Yoshinori, Ukai, Yojiro

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Reversal by NS-7, a neuroprotective compound, of the decrease in transcription factor CREB mRNA expression in rat brain after permanent middle cerebral artery occlusion by HIROUCHI, Masaaki, ITOH, Yoshinori, AOKI, Yasuaki, OKA, Michiko, UKAI, Yojiro

“…The effect of a neuroprotective agent NS-7 on changes in mRNA expressions for cyclic AMP responsive element binding protein (CREB) and several neurotrophins…”
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Na+ and high-voltage-activated Ca2+ channel blocking actions of NS-7, a novel neuroprotective agent, in NG108-15 cells by SUMA, C, HAYASHI, S, UKAI, Y, YOSHIKUNI, Y, KIMURA, K

“…The actions of a novel neuroprotective compound, 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride (NS-7), on voltage-gated Na+,…”
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Regulation by autonomic nerves of bladder neck sphincter function--mainly on inhibitory NANC nerves by Ukai, Yojiro, Noda, Kumiko, Toda, Noboru

“…This article describes current information concerning analyses of contraction and relaxation associated with electrical stimulation of efferent nerves in…”
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Inhibitory influence from the nucleus reticularis pontis oralis on the micturition reflex induced by electrical stimulation of the pontine micturition center in cats by Kimura, Yutaka, Ukai, Yojiro, Kimura, Kiyoshi, Sugaya, Kimio, Nishizawa, Osamu

“…An inhibitory influence from the nucleus reticularis pontis oralis on the micturition induced by electrical stimulation of the pontine micturition center was…”
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Mechanisms of the suppression of the bladder activity by flavoxate by Kimura, Y, Sasaki, Y, Hamada, K, Fukui, H, Ukai, Y, Yoshikuni, Y, Kimura, K, Sugaya, K, Nishizawa, O

“…This study was designed to clarify the primary site of action of flavoxate, clinically used for the treatment of urinary frequency. In rats, the effect of…”
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Effect of NS-21, an Anticholinergic Drug with Calcium Antagonistic Activity, on Lower Urinary Tract Function in a Rat Model of Urinary Frequency by Sasaki, Yasuo, Hamada, Kozo, Yamazaki, Chiemi, Seto, Toshie, Kimura, Yutaka, Ukai, Yojiro, Yoshikuni, Yoshiaki, Kimura, Kiyoshi

“…Background: NS‐21 is under development for the treatment of urinary frequency and urinary incontinence. The purpose of this study was to investigate the…”
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Blockade of voltage-sensitive sodium channels by NS-7, a novel neuroprotective compound, in the rat brain by Shimidzu, Takako, Itoh, Y., Tatsumi, Shigeru, Hayashi, Seiji, Ukai, Yojiro, Yoshikuni, Yoshiaki, Kimura, Kiyoshi

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Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils by Kyoi, Takashi, Noda, Kumiko, Oka, Michiko, Ukai, Yojiro

“…Neutrophil superoxide production is implicated in the pathogenesis of gastric mucosal damage induced by various ulcerative agents and Helicobacter pylori…”
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