Search Results - "Ukai, Ippo"

Leucine-rich repeat 2 of human Toll-like receptor 4 contains the binding site for inhibitory monoclonal antibodies by Tsukamoto, Hiroki, Ukai, Ippo, Yamagata, Yuki, Takeuchi, Shino, Kubota, Kanae, Kozakai, Sao, Suzuki, Naoto, Kimoto, Masao, Tomioka, Yoshihisa

“…•A novel anti-TLR4 mAb HTB2 was obtained by cross-block screening against HT52.•HTB2 inhibits LPS-induced TLR4 activation.•HT52 and HTB2 epitopes were…”
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An inhibitory epitope of human Toll‐like receptor 4 resides on leucine‐rich repeat 13 and is recognized by a monoclonal antibody by Tsukamoto, Hiroki, Yamagata, Yuki, Ukai, Ippo, Takeuchi, Shino, Okubo, Misaki, Kobayashi, Yohei, Kozakai, Sao, Kubota, Kanae, Mumasaki, Muneo, Kanemitsu, Yoshitomi, Matsumoto, Yotaro, Tomioka, Yoshihisa

“…Lipopolysaccharide (LPS)‐induced activation of Toll‐like receptor 4 (TLR4) elicits the innate immune response and can trigger septic shock if excessive. Two…”
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An inhibitory epitope of human Toll‐like receptor 4 resides on leucine‐rich repeat 13 and is recognized by a monoclonal antibody by Tsukamoto, Hiroki, Yamagata, Yuki, Ukai, Ippo, Takeuchi, Shino, Okubo, Misaki, Kobayashi, Yohei, Kozakai, Sao, Kubota, Kanae, Numasaki, Muneo, Kanemitsu, Yoshitomi, Matsumoto, Yotaro, Tomioka, Yoshihisa

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Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1–IKKϵ–IRF3 axis activation by Tsukamoto, Hiroki, Takeuchi, Shino, Kubota, Kanae, Kobayashi, Yohei, Kozakai, Sao, Ukai, Ippo, Shichiku, Ayumi, Okubo, Misaki, Numasaki, Muneo, Kanemitsu, Yoshitomi, Matsumoto, Yotaro, Nochi, Tomonori, Watanabe, Kouichi, Aso, Hisashi, Tomioka, Yoshihisa

“…Toll-like receptor 4 (TLR4) is an indispensable immune receptor for lipopolysaccharide (LPS), a major component of the Gram-negative bacterial cell wall…”
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MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor 4 with extrinsic soluble MD-2 on the cell surface by Tsukamoto, Hiroki, Ihara, Hideyuki, Ito, Ritsu, Ukai, Ippo, Suzuki, Naoto, Kimoto, Masao, Tomioka, Yoshihisa, Ikeda, Yoshitaka

“…•Three mAbs are specific for combinatorial epitopes shared by TLR4 and MD-2.•Extracellular complex formation of TLR4 with secreted MD-2 was detectable using…”
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