Search Results - "Ujjini, Manjunatha"

Use-case scenarios for an anti-Cryptosporidium therapeutic by Ashigbie, Paul G, Shepherd, Susan, Steiner, Kevin L, Amadi, Beatrice, Aziz, Natasha, Manjunatha, Ujjini H, Spector, Jonathan M, Diagana, Thierry T, Kelly, Paul

“…Cryptosporidium is a widely distributed enteric parasite that has an increasingly appreciated pathogenic role, particularly in pediatric diarrhea. While…”
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Perspective: Challenges and opportunities in TB drug discovery from phenotypic screening by Manjunatha, Ujjini H., Smith, Paul W.

“…[Display omitted] Tuberculosis poses a major global health problem and multi-drug resistant strains are increasingly prevalent. Hence there is an urgent need…”
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Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents by Lakshminarayana, Suresh B, Huat, Tan Bee, Ho, Paul C, Manjunatha, Ujjini H, Dartois, Véronique, Dick, Thomas, Rao, Srinivasa P S

“…The discovery and development of TB drugs has met limited success, with two new drugs approved over the last 40 years. Part of the difficulty resides in the…”
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A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis by Manjunatha, Ujjini H., Vinayak, Sumiti, Zambriski, Jennifer A., Chao, Alexander T., Sy, Tracy, Noble, Christian G., Bonamy, Ghislain M. C., Kondreddi, Ravinder R., Zou, Bin, Gedeck, Peter, Brooks, Carrie F., Herbert, Gillian T., Sateriale, Adam, Tandel, Jayesh, Noh, Susan, Lakshminarayana, Suresh B., Lim, Siau H., Goodman, Laura B., Bodenreider, Christophe, Feng, Gu, Zhang, Lijun, Blasco, Francesca, Wagner, Juergen, Leong, F. Joel, Striepen, Boris, Diagana, Thierry T.

“…Diarrhoeal disease is responsible for 8.6% of global child mortality. Recent epidemiological studies found the protozoan parasite Cryptosporidium to be a…”
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Drug discovery for parasitic diseases: powered by technology, enabled by pharmacology, informed by clinical science by Rao, Srinivasa P.S., Manjunatha, Ujjini H., Mikolajczak, Sebastian, Ashigbie, Paul G., Diagana, Thierry T.

“…Patients suffering from parasitic diseases face considerable unmet therapeutic needs.Recent scientific advances in drug discovery technology, and in…”
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Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling by Lim, Siew Pheng, Noble, Christian Guy, Seh, Cheah Chen, Soh, Tingjin Sherryl, El Sahili, Abbas, Chan, Grace Kar Yarn, Lescar, Julien, Arora, Rishi, Benson, Timothy, Nilar, Shahul, Manjunatha, Ujjini, Wan, Kah Fei, Dong, Hongping, Xie, Xuping, Shi, Pei-Yong, Yokokawa, Fumiaki

“…Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the…”
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Vitamin B6 biosynthesis is essential for survival and virulence of Mycobacterium tuberculosis by Dick, Thomas, Manjunatha, Ujjini, Kappes, Barbara, Gengenbacher, Martin

“…With 500 000 cases of multidrug‐resistant tuberculosis there is an urgent need for attractive targets to enable the discovery of novel antimycobacterials. The…”
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Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides: A Promising Class of Antituberculosis Agents by Kondreddi, Ravinder Reddy, Jiricek, Jan, Rao, Srinivasa P. S, Lakshminarayana, Suresh B, Camacho, Luis R, Rao, Ranga, Herve, Maxime, Bifani, Pablo, Ma, Ngai Ling, Kuhen, Kelli, Goh, Anne, Chatterjee, Arnab K, Dick, Thomas, Diagana, Thierry T, Manjunatha, Ujjini H, Smith, Paul W

“…Indole-2-carboxamides have been identified as a promising class of antituberculosis agents from phenotypic screening against mycobacteria. One of the hits,…”
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PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release by Singh, Ramandeep, Manjunatha, Ujjini, Boshoff, Helena I.M, Ha, Young Hwan, Niyomrattanakit, Pornwaratt, Ledwidge, Richard, Dowd, Cynthia S, Lee, Ill Young, Kim, Pilho, Zhang, Liang, Kang, Sunhee, Keller, Thomas H, Jiricek, Jan, Barry, Clifton E. 3rd

“…Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of tuberculosis. These prodrugs require intracellular activation for…”
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Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design by Yokokawa, Fumiaki, Nilar, Shahul, Noble, Christian G, Lim, Siew Pheng, Rao, Ranga, Tania, Stefani, Wang, Gang, Lee, Gladys, Hunziker, Jürg, Karuna, Ratna, Manjunatha, Ujjini, Shi, Pei-Yong, Smith, Paul W

“…The discovery and optimization of non-nucleoside dengue viral RNA-dependent-RNA polymerase (RdRp) inhibitors are described. An X-ray-based fragment screen of…”
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Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections by Rao, Srinivasa P S, Gould, Matthew K, Noeske, Jonas, Saldivia, Manuel, Jumani, Rajiv S, Ng, Pearly S, René, Olivier, Chen, Yen-Liang, Kaiser, Marcel, Ritchie, Ryan, Francisco, Amanda Fortes, Johnson, Nila, Patra, Debjani, Cheung, Harry, Deniston, Colin, Schenk, Andreas D, Cortopassi, Wilian A, Schmidt, Remo S, Wiedemar, Natalie, Thomas, Bryanna, Palkar, Rima, Ghafar, Nahdiyah A, Manoharan, Vanessa, Luu, Catherine, Gable, Jonathan E, Wan, Kah Fei, Myburgh, Elmarie, Mottram, Jeremy C, Barnes, Whitney, Walker, John, Wartchow, Charles, Aziz, Natasha, Osborne, Colin, Wagner, Juergen, Sarko, Christopher, Kelly, John M, Manjunatha, Ujjini H, Mäser, Pascal, Jiricek, Jan, Lakshminarayana, Suresh B, Barrett, Michael P, Diagana, Thierry T

“…Millions who live in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections, which cause Chagas disease and human African…”
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Direct inhibitors of InhA are active against Mycobacterium tuberculosis by Manjunatha, Ujjini H, S Rao, Srinivasa P, Kondreddi, Ravinder Reddy, Noble, Christian G, Camacho, Luis R, Tan, Bee H, Ng, Seow H, Ng, Pearly Shuyi, Ma, Ng L, Lakshminarayana, Suresh B, Herve, Maxime, Barnes, Susan W, Yu, Weixuan, Kuhen, Kelli, Blasco, Francesca, Beer, David, Walker, John R, Tonge, Peter J, Glynne, Richard, Smith, Paul W, Diagana, Thierry T

“…New chemotherapeutic agents are urgently required to combat the global spread of multidrug-resistant tuberculosis (MDR-TB). The mycobacterial enoyl reductase…”
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Pyrrolo[3,4‑c]pyridine-1,3(2H)‑diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration by van der Westhuyzen, Renier, Winks, Susan, Wilson, Colin R, Boyle, Grant A, Gessner, Richard K, Soares de Melo, Candice, Taylor, Dale, de Kock, Carmen, Njoroge, Mathew, Brunschwig, Christel, Lawrence, Nina, Rao, Srinivasa P.S, Sirgel, Frederick, van Helden, Paul, Seldon, Ronnett, Moosa, Atica, Warner, Digby F, Arista, Luca, Manjunatha, Ujjini H, Smith, Paul W, Street, Leslie J, Chibale, Kelly

“…High-throughput screening of a library of small polar molecules against Mycobacterium tuberculosis led to the identification of a phthalimide-containing ester…”
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Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates by Via, Laura E, Lin, P. Ling, Ray, Sonja M, Carrillo, Jose, Allen, Shannon Sedberry, Eum, Seok Yong, Taylor, Kimberly, Klein, Edwin, Manjunatha, Ujjini, Gonzales, Jacqueline, Lee, Eun Gae, Park, Seung Kyu, Raleigh, James A, Cho, Sang Nae, McMurray, David N, Flynn, JoAnne L, Barry, Clifton E. III

“…Understanding the physical characteristics of the local microenvironment in which Mycobacterium tuberculosis resides is an important goal that may allow the…”
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Benzoheterocyclic Oxime Carbamates Active against Mycobacterium tuberculosis: Synthesis, Structure–Activity Relationship, Metabolism, and Biology Triaging by van der Westhuyzen, Renier, Mabhula, Amanda, Njaria, Paul M, Müller, Rudolf, Ngumbu Muhunga, Denis, Taylor, Dale, Lawrence, Nina, Njoroge, Mathew, Brunschwig, Christel, Moosa, Atica, Singh, Vinayak, Rao, Srinivasa P.S, Manjunatha, Ujjini H, Smith, Paul W, Warner, Digby F, Street, Leslie J, Chibale, Kelly

“…Screening of a library of small polar molecules against Mycobacterium tuberculosis (Mtb) led to the identification of a potent benzoheterocyclic oxime…”
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Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis by Lakshminarayana, Suresh B, Boshoff, Helena I M, Cherian, Joseph, Ravindran, Sindhu, Goh, Anne, Jiricek, Jan, Nanjundappa, Mahesh, Nayyar, Amit, Gurumurthy, Meera, Singh, Ramandeep, Dick, Thomas, Blasco, Francesca, Barry, 3rd, Clifton E, Ho, Paul C, Manjunatha, Ujjini H

“…PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation…”
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Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824 by Cellitti, Susan E., Shaffer, Jennifer, Jones, David H., Mukherjee, Tathagata, Gurumurthy, Meera, Bursulaya, Badry, Boshoff, Helena I., Choi, Inhee, Nayyar, Amit, Lee, Yong Sok, Cherian, Joseph, Niyomrattanakit, Pornwaratt, Dick, Thomas, Manjunatha, Ujjini H., Barry, Clifton E., Spraggon, Glen, Geierstanger, Bernhard H.

“…Tuberculosis continues to be a global health threat, making bicyclic nitroimidazoles an important new class of therapeutics. A deazaflavin-dependent…”
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A novel F420‐dependent anti‐oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents by Gurumurthy, Meera, Rao, Martin, Mukherjee, Tathagata, Rao, Srinivasa P. S., Boshoff, Helena I., Dick, Thomas, Barry, Clifton E., Manjunatha, Ujjini H.

“…Summary Mycobacterium tuberculosis (Mtb) is an aerobic bacterium that persists intracellularly in host macrophages and has evolved diverse mechanisms to combat…”
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Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis by Rao, Srinivasa P S, Lakshminarayana, Suresh B, Kondreddi, Ravinder R, Herve, Maxime, Camacho, Luis R, Bifani, Pablo, Kalapala, Sarath K, Jiricek, Jan, Ma, Ng L, Tan, Bee H, Ng, Seow H, Nanjundappa, Mahesh, Ravindran, Sindhu, Seah, Peck G, Thayalan, Pamela, Lim, Siao H, Lee, Boon H, Goh, Anne, Barnes, Whitney S, Chen, Zhong, Gagaring, Kerstin, Chatterjee, Arnab K, Pethe, Kevin, Kuhen, Kelli, Walker, John, Feng, Gu, Babu, Sreehari, Zhang, Lijun, Blasco, Francesca, Beer, David, Weaver, Margaret, Dartois, Veronique, Glynne, Richard, Dick, Thomas, Smith, Paul W, Diagana, Thierry T, Manjunatha, Ujjini H

“…New chemotherapeutic compounds against multidrug-resistant Mycobacterium tuberculosis (Mtb) are urgently needed to combat drug resistance in tuberculosis (TB)…”
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Identification of a Nitroimidazo-Oxazine-Specific Protein Involved in PA-824 Resistance in Mycobacterium tuberculosis by Manjunatha, Ujjini H., Boshoff, Helena, Dowd, Cynthia S., Zhang, Liang, Albert, Thomas J., Norton, Jason E., Daniels, Lacy, Dick, Thomas, Pang, Siew Siew, Barry, Clifton E.

“…PA-824 is a promising new compound for the treatment of tuberculosis that is currently undergoing human trials. Like its progenitors metronidazole and…”
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