Search Results - "Uitdehaag, J C M"

MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia by Canté-Barrett, K, Spijkers-Hagelstein, J A P, Buijs-Gladdines, J G C A M, Uitdehaag, J C M, Smits, W K, van der Zwet, J, Buijsman, R C, Zaman, G J R, Pieters, R, Meijerink, J P P

“…We identified mutations in the IL7Ra gene or in genes encoding the downstream signaling molecules JAK1, JAK3, STAT5B, N-RAS, K-RAS, NF1, AKT and PTEN in 49% of…”
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Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model by Maia, A.R.R., de Man, J., Boon, U., Janssen, A., Song, J.-Y., Omerzu, M., Sterrenburg, J.G., Prinsen, M.B.W., Willemsen-Seegers, N., de Roos, J.A.D.M., van Doornmalen, A.M., Uitdehaag, J.C.M., Kops, G.J.P.L., Jonkers, J., Buijsman, R.C., Zaman, G.J.R., Medema, R.H.

“…Triple-negative breast cancers (TNBC) are considered the most aggressive type of breast cancer, for which no targeted therapy exists at the moment. These…”
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Structural modeling of JAK1 mutations in T-cell acute lymphoblastic leukemia reveals a second contact site between pseudokinase and kinase domains by Canté-Barrett, Kirsten, Uitdehaag, Joost C M, Meijerink, Jules P P

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