Search Results - "Uhm, Heesoo"
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Quantification of purified endogenous miRNAs with high sensitivity and specificity
Published in Nature communications (27-11-2020)“…MicroRNAs (miRNAs) are short (19–24 nt) non-coding RNAs that suppress the expression of protein coding genes at the post-transcriptional level. Differential…”
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Rho-dependent transcription termination proceeds via three routes
Published in Nature communications (29-03-2022)“…Rho is a general transcription termination factor in bacteria, but many aspects of its mechanism of action are unclear. Diverse models have been proposed for…”
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Transcription reinitiation by recycling RNA polymerase that diffuses on DNA after releasing terminated RNA
Published in Nature communications (23-01-2020)“…Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential…”
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Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors
Published in Molecular brain (29-11-2017)“…Protein kinase M zeta (PKMζ), a constitutively active, atypical protein kinase C isoform, maintains a high level of expression in the brain after the induction…”
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Single-mode termination of phage transcriptions, disclosing bacterial adaptation for facilitated reinitiations
Published in Nucleic acids research (16-07-2024)“…Abstract Bacterial and bacteriophage RNA polymerases (RNAPs) have divergently evolved and share the RNA hairpin-dependent intrinsic termination of…”
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Single-molecule FRET studies on the cotranscriptional folding of a thiamine pyrophosphate riboswitch
Published in Proceedings of the National Academy of Sciences - PNAS (09-01-2018)“…Because RNAs fold as they are being synthesized, their transcription rate can affect their folding. Here, we report the results of single-molecule fluorescence…”
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Observation of Intrinsic Conformational Dynamics of TPP Riboswitch and its Structural Transition Induced by TPP Binding
Published in Biophysical journal (29-01-2013)Get full text
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RNA polymerase clamp conformational dynamics: long-lived states and modulation by crowding, cations, and nonspecific DNA binding
Published in Nucleic acids research (18-03-2021)“…Abstract The RNA polymerase (RNAP) clamp, a mobile structural element conserved in RNAP from all domains of life, has been proposed to play critical roles at…”
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Three kinetically distinct but compatible routes of Rho-dependent termination uncovered by single-molecule transcription imaging
Published in Biophysical journal (10-02-2023)Get full text
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Ligand Recognition Mechanism of Thiamine Pyrophosphate Riboswitch Aptamer
Published in Bulletin of the Korean Chemical Society (01-12-2017)“…Riboswitches regulate gene expression by coupling ligand binding to a structural transition of the riboswitch, but the coupling mechanism is still…”
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Multiple RPAs make WRN syndrome protein a superhelicase
Published in Nucleic acids research (18-05-2018)“…Abstract RPA is known to stimulate the helicase activity of Werner syndrome protein (WRN), but the exact stimulation mechanism is not understood. We use…”
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Single-Molecule FRET Combined with Magnetic Tweezers at Low Force Regime
Published in Bulletin of the Korean Chemical Society (01-03-2016)“…KCI Citation Count: 0…”
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