Search Results - "Uhlitz, Florian"

A compendium of ERK targets by Ünal, Evrim B., Uhlitz, Florian, Blüthgen, Nils

“…The RAF‐MEK‐ERK cascade is one of the most studied signaling pathways as it controls many vital cellular programs. There has been an immense amount of effort…”
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Perturbation-response genes reveal signaling footprints in cancer gene expression by Schubert, Michael, Klinger, Bertram, Klünemann, Martina, Sieber, Anja, Uhlitz, Florian, Sauer, Sascha, Garnett, Mathew J., Blüthgen, Nils, Saez-Rodriguez, Julio

“…Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug research. A common approach is to infer signaling activity of pathways…”
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Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma by Bischoff, Philip, Trinks, Alexandra, Obermayer, Benedikt, Pett, Jan Patrick, Wiederspahn, Jennifer, Uhlitz, Florian, Liang, Xizi, Lehmann, Annika, Jurmeister, Philipp, Elsner, Aron, Dziodzio, Tomasz, Rückert, Jens-Carsten, Neudecker, Jens, Falk, Christine, Beule, Dieter, Sers, Christine, Morkel, Markus, Horst, David, Blüthgen, Nils, Klauschen, Frederick

“…Recent developments in immuno-oncology demonstrate that not only cancer cells, but also the tumor microenvironment can guide precision medicine. A…”
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Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium by Brandt, Raphael, Sell, Thomas, Lüthen, Mareen, Uhlitz, Florian, Klinger, Bertram, Riemer, Pamela, Giesecke-Thiel, Claudia, Schulze, Silvia, El-Shimy, Ismail Amr, Kunkel, Desiree, Fauler, Beatrix, Mielke, Thorsten, Mages, Norbert, Herrmann, Bernhard G., Sers, Christine, Blüthgen, Nils, Morkel, Markus

“…Oncogenic mutations in KRAS or BRAF are frequent in colorectal cancer and activate the ERK kinase. Here, we find graded ERK phosphorylation correlating with…”
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Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer by Uhlitz, Florian, Bischoff, Philip, Peidli, Stefan, Sieber, Anja, Trinks, Alexandra, Lüthen, Mareen, Obermayer, Benedikt, Blanc, Eric, Ruchiy, Yana, Sell, Thomas, Mamlouk, Soulafa, Arsie, Roberto, Wei, Tzu‐Ting, Klotz‐Noack, Kathleen, Schwarz, Roland F, Sawitzki, Birgit, Kamphues, Carsten, Beule, Dieter, Landthaler, Markus, Sers, Christine, Horst, David, Blüthgen, Nils, Morkel, Markus

“…In colorectal cancer, oncogenic mutations transform a hierarchically organized and homeostatic epithelium into invasive cancer tissue lacking visible…”
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An immediate–late gene expression module decodes ERK signal duration by Uhlitz, Florian, Sieber, Anja, Wyler, Emanuel, Fritsche‐Guenther, Raphaela, Meisig, Johannes, Landthaler, Markus, Klinger, Bertram, Blüthgen, Nils

“…The RAF‐MEK‐ERK signalling pathway controls fundamental, often opposing cellular processes such as proliferation and apoptosis. Signal duration has been…”
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Identification of transcriptional programs using dense vector representations defined by mutual information with GeneVector by Ceglia, Nicholas, Sethna, Zachary, Freeman, Samuel S., Uhlitz, Florian, Bojilova, Viktoria, Rusk, Nicole, Burman, Bharat, Chow, Andrew, Salehi, Sohrab, Kabeer, Farhia, Aparicio, Samuel, Greenbaum, Benjamin D., Shah, Sohrab P., McPherson, Andrew

“…Deciphering individual cell phenotypes from cell-specific transcriptional processes requires high dimensional single cell RNA sequencing. However, current…”
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An immediate–late gene expression module decodes ERK signal duration by Uhlitz, Florian, Sieber, Anja, Wyler, Emanuel, Fritsche‐Guenther, Raphaela, Meisig, Johannes, Landthaler, Markus, Klinger, Bertram, Blüthgen, Nils

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SFPQ Depletion Is Synthetically Lethal with BRAFV600E in Colorectal Cancer Cells by Klotz-Noack, Kathleen, Klinger, Bertram, Rivera, Maria, Bublitz, Natalie, Uhlitz, Florian, Riemer, Pamela, Lüthen, Mareen, Sell, Thomas, Kasack, Katharina, Gastl, Bastian, Ispasanie, Sylvia S.S., Simon, Tincy, Janssen, Nicole, Schwab, Matthias, Zuber, Johannes, Horst, David, Blüthgen, Nils, Schäfer, Reinhold, Morkel, Markus, Sers, Christine

“…Oncoproteins such as the BRAFV600E kinase endow cancer cells with malignant properties, but they also create unique vulnerabilities. Targeting of…”
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Rejuvenating dysfunctional T cells in ovarian cancer: CD28 is the license to kill by Uhlitz, Florian, Zamarin, Dmitriy

“…High-grade serous ovarian cancers (HGSOCs) exhibit limited response to immune checkpoint blockade. In a new study in Cancer Cell, Duraiswamy et al. highlight…”
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Ovarian cancer mutational processes drive site-specific immune evasion by Vázquez-García, Ignacio, Uhlitz, Florian, Ceglia, Nicholas, Lim, Jamie L. P., Wu, Michelle, Mohibullah, Neeman, Niyazov, Juliana, Ruiz, Arvin Eric B., Boehm, Kevin M., Bojilova, Viktoria, Fong, Christopher J., Funnell, Tyler, Grewal, Diljot, Havasov, Eliyahu, Leung, Samantha, Pasha, Arfath, Patel, Druv M., Pourmaleki, Maryam, Rusk, Nicole, Shi, Hongyu, Vanguri, Rami, Williams, Marc J., Zhang, Allen W., Broach, Vance, Chi, Dennis S., Da Cruz Paula, Arnaud, Gardner, Ginger J., Kim, Sarah H., Lennon, Matthew, Long Roche, Kara, Sonoda, Yukio, Zivanovic, Oliver, Kundra, Ritika, Viale, Agnes, Derakhshan, Fatemeh N., Geneslaw, Luke, Issa Bhaloo, Shirin, Maroldi, Ana, Nunez, Rahelly, Pareja, Fresia, Stylianou, Anthe, Vahdatinia, Mahsa, Bykov, Yonina, Grisham, Rachel N., Liu, Ying L., Lakhman, Yulia, Nikolovski, Ines, Kelly, Daniel, Gao, Jianjiong, Schietinger, Andrea, Hollmann, Travis J., Bakhoum, Samuel F., Soslow, Robert A., Ellenson, Lora H., Abu-Rustum, Nadeem R., Aghajanian, Carol, Friedman, Claire F., McPherson, Andrew, Weigelt, Britta, Zamarin, Dmitriy, Shah, Sohrab P.

“…High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability 1 – 4 patterned by distinct mutational processes 5 , 6 , tumour…”
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Single-cell genomic variation induced by mutational processes in cancer by Funnell, Tyler, O’Flanagan, Ciara H., Williams, Marc J., McPherson, Andrew, McKinney, Steven, Kabeer, Farhia, Lee, Hakwoo, Salehi, Sohrab, Vázquez-García, Ignacio, Shi, Hongyu, Leventhal, Emily, Masud, Tehmina, Eirew, Peter, Yap, Damian, Zhang, Allen W., Lim, Jamie L. P., Wang, Beixi, Brimhall, Jazmine, Biele, Justina, Ting, Jerome, Au, Vinci, Van Vliet, Michael, Liu, Yi Fei, Beatty, Sean, Lai, Daniel, Pham, Jenifer, Grewal, Diljot, Abrams, Douglas, Havasov, Eliyahu, Leung, Samantha, Bojilova, Viktoria, Moore, Richard A., Rusk, Nicole, Uhlitz, Florian, Ceglia, Nicholas, Weiner, Adam C., Zaikova, Elena, Douglas, J. Maxwell, Zamarin, Dmitriy, Weigelt, Britta, Kim, Sarah H., Da Cruz Paula, Arnaud, Reis-Filho, Jorge S., Martin, Spencer D., Li, Yangguang, Xu, Hong, de Algara, Teresa Ruiz, Lee, So Ra, Llanos, Viviana Cerda, Huntsman, David G., McAlpine, Jessica N., Shah, Sohrab P., Aparicio, Samuel

“…How cell-to-cell copy number alterations that underpin genomic instability 1 in human cancers drive genomic and phenotypic variation, and consequently the…”
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Mutation-specific effects of NRAS oncogenes in colorectal cancer cells by Kuhn, Natalia, Klinger, Bertram, Uhlitz, Florian, Sieber, Anja, Rivera, Maria, Klotz-Noack, Kathleen, Fichtner, Iduna, Hoffmann, Jens, Blüthgen, Nils, Falk, Christine, Sers, Christine, Schäfer, Reinhold

“…In colorectal cancer (CRC), the prevalence of NRAS mutations (5–9%) is inferior to that of KRAS mutations (40–50%). NRAS mutations feature lately during tumour…”
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Abstract PR012: Evolutionary dynamics of whole-genome doubling in ovarian cancer by Vázquez-García, Ignacio, Myers, Matthew, Williams, Marc J., Freeman, Samuel S., Li, Jun, Shi, Hongyu, Satas, Gryte, Ceglia, Nicholas, Uhlitz, Florian, Weigelt, Britta, Zamarin, Dmitriy, McPherson, Andrew, Bakhoum, Samuel F., Shah, Sohrab P.

“…Abstract Chromosomal instability (CIN) is a major driver of tumor progression and treatment resistance in many cancers. CIN is characterized by ongoing…”
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Abstract LB049: Spatial immune determinants of ICB response in STK11-mutated non-small cell lung cancer by Uhlitz, Florian, Linn, Douglas, Krall, Elsa Beyer, Egger, Jacklynn, Rizvi, Hira, Chang, Jason, Nicholson, Benjamin, Vanguri, Rami, Chow, Andrew, Hellmann, Matthew, Shah, Sohrab

“…Abstract Response to immune checkpoint blockade (ICB) in non-small cell lung cancers (NSCLC) is associated with recurring mutations in tumor suppressor genes…”
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Abstract 102: Transient chromosomal instability as a driver of ovarian cancer genome evolution by Vazquez-Garcia, Ignacio, Uhlitz, Florian, Williams, Marc J., Li, Jun, Shi, Hongyu, Freeman, Samuel, Myers, Matthew, Consortium, MSK SPECTRUM, Weigelt, Britta, Zamarin, Dmitriy, McPherson, Andrew, Bakhoum, Samuel F., Shah, Sohrab P.

“…Abstract Chromosomal instability (CIN) is a major driver of tumor progression and treatment resistance in many cancers. CIN is characterized by ongoing…”
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ERK Signal Duration Decoding by mRNA Dynamics by Uhlitz, Florian Sören

“…The RAF-MEK-ERK signalling pathway controls fundamental, often opposing cellular processes such as proliferation and apoptosis. Signal duration has been…”
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Erratum To: An immediate–late gene expression module decodes ERK signal duration by Uhlitz, Florian, Sieber, Anja, Wyler, Emanuel, Fritsche‐Guenther, Raphaela, Meisig, Johannes, Landthaler, Markus, Klinger, Bertram, Blüthgen, Nils

“…Graphical Abstract…”
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Abstract 2553: Immune and malignant cell phenotypes of ovarian cancer are determined by distinct mutational processes by Vázquez-García, Ignacio, Uhlitz, Florian, Ceglia, Nicholas, Lim, Jamie L., Wu, Michelle, Mohibullah, Neeman, Ruiz, Arvin Eric B., Boehm, Kevin M., Bojilova, Viktoria, Fong, Christopher J., Funnell, Tyler, Grewal, Diljot, Havasov, Eliyahu, Leung, Samantha, Pasha, Arfath, Patel, Druv M., Pourmaleki, Maryam, Rusk, Nicole, Shi, Hongyu, Vanguri, Rami, Williams, Marc J., Zhang, Allen W., Broach, Vance, Chi, Dennis S., Paula, Arnaud Da Cruz, Gardner, Ginger J., Kim, Sarah H., Lennon, Matthew, Roche, Kara Long, Sonoda, Yukio, Zivanovic, Oliver, Kundra, Ritika, Viale, Agnes, Bykov, Yonina, Derakhshan, Fatemeh N., Geneslaw, Luke, Maroldi, Ana, Schietinger, Andrea, Hollmann, Travis J., Bakhoum, Samuel F., Soslow, Robert A., Ellenson, Lora H., Abu-Rustum, Nadeem, Aghajanian, Carol, Friedman, Claire F., McPherson, Andrew, Weigelt, Britta, Zamarin, Dmitriy, Shah, Sohrab P.

“…Abstract High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability patterned by distinct mutational processes, a high degree of…”
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SFPQ Depletion Is Synthetically Lethal with BRAF V600E in Colorectal Cancer Cells by Klotz-Noack, Kathleen, Klinger, Bertram, Rivera, Maria, Bublitz, Natalie, Uhlitz, Florian, Riemer, Pamela, Lüthen, Mareen, Sell, Thomas, Kasack, Katharina, Gastl, Bastian, Ispasanie, Sylvia S S, Simon, Tincy, Janssen, Nicole, Schwab, Matthias, Zuber, Johannes, Horst, David, Blüthgen, Nils, Schäfer, Reinhold, Morkel, Markus, Sers, Christine

“…Oncoproteins such as the BRAF kinase endow cancer cells with malignant properties, but they also create unique vulnerabilities. Targeting of BRAF -driven…”
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