Search Results - "Uhlén, Mathias"

The protein expression profile of ACE2 in human tissues by Hikmet, Feria, Méar, Loren, Edvinsson, Åsa, Micke, Patrick, Uhlén, Mathias, Lindskog, Cecilia

“…The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection,…”
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Next generation plasma proteome profiling to monitor health and disease by Zhong, Wen, Edfors, Fredrik, Gummesson, Anders, Bergström, Göran, Fagerberg, Linn, Uhlén, Mathias

“…The need for precision medicine approaches to monitor health and disease makes it important to develop sensitive and accurate assays for proteome profiles in…”
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Developmental trajectory of the healthy human gut microbiota during the first 5 years of life by Roswall, Josefine, Olsson, Lisa M., Kovatcheva-Datchary, Petia, Nilsson, Staffan, Tremaroli, Valentina, Simon, Marie-Christine, Kiilerich, Pia, Akrami, Rozita, Krämer, Manuela, Uhlén, Mathias, Gummesson, Anders, Kristiansen, Karsten, Dahlgren, Jovanna, Bäckhed, Fredrik

“…The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different bacteria…”
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A deep proteome and transcriptome abundance atlas of 29 healthy human tissues by Wang, Dongxue, Eraslan, Basak, Wieland, Thomas, Hallström, Björn, Hopf, Thomas, Zolg, Daniel Paul, Zecha, Jana, Asplund, Anna, Li, Li‐hua, Meng, Chen, Frejno, Martin, Schmidt, Tobias, Schnatbaum, Karsten, Wilhelm, Mathias, Ponten, Frederik, Uhlen, Mathias, Gagneur, Julien, Hahne, Hannes, Kuster, Bernhard

“…Genome‐, transcriptome‐ and proteome‐wide measurements provide insights into how biological systems are regulated. However, fundamental aspects relating to…”
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Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes by Bidkhori, Gholamreza, Benfeitas, Rui, Klevstig, Martina, Zhang, Cheng, Nielsen, Jens, Uhlen, Mathias, Boren, Jan, Mardinoglu, Adil

“…Hepatocellular carcinoma (HCC) is one of the most frequent forms of liver cancer, and effective treatment methods are limited due to tumor heterogeneity. There…”
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Gene‐specific correlation of RNA and protein levels in human cells and tissues by Edfors, Fredrik, Danielsson, Frida, Hallström, Björn M, Käll, Lukas, Lundberg, Emma, Pontén, Fredrik, Forsström, Björn, Uhlén, Mathias

“…An important issue for molecular biology is to establish whether transcript levels of a given gene can be used as proxies for the corresponding protein levels…”
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Correlations between RNA and protein expression profiles in 23 human cell lines by Gry, Marcus, Rimini, Rebecca, Strömberg, Sara, Asplund, Anna, Pontén, Fredrik, Uhlén, Mathias, Nilsson, Peter

“…The Central Dogma of biology holds, in famously simplified terms, that DNA makes RNA makes proteins, but there is considerable uncertainty regarding the…”
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Prediction of the human membrane proteome by Fagerberg, Linn, Jonasson, Kalle, von Heijne, Gunnar, Uhlén, Mathias, Berglund, Lisa

“…Membrane proteins are key molecules in the cell, and are important targets for pharmaceutical drugs. Few three-dimensional structures of membrane proteins have…”
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Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder by Stenström, Lovisa, Mahdessian, Diana, Gnann, Christian, Cesnik, Anthony J, Ouyang, Wei, Leonetti, Manuel D, Uhlén, Mathias, Cuylen‐Haering, Sara, Thul, Peter J, Lundberg, Emma

“…The nucleolus is essential for ribosome biogenesis and is involved in many other cellular functions. We performed a systematic spatiotemporal dissection of the…”
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Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease by Rosario, Dorines, Bidkhori, Gholamreza, Lee, Sunjae, Bedarf, Janis, Hildebrand, Falk, Le Chatelier, Emmanuelle, Uhlen, Mathias, Ehrlich, Stanislav Dusko, Proctor, Gordon, Wüllner, Ullrich, Mardinoglu, Adil, Shoaie, Saeed

“…Parkinson’s disease (PD) is the most common progressive neurological disorder compromising motor functions. However, nonmotor symptoms, such as…”
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A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome by Robinson, Jonathan L., Feizi, Amir, Uhlén, Mathias, Nielsen, Jens

“…The collection of proteins secreted from a cell—the secretome—is of particular interest in cancer pathophysiology due to its diagnostic potential and role in…”
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Cell Type-Specific Expression of Testis Elevated Genes Based on Transcriptomics and Antibody-Based Proteomics by Pineau, Charles, Hikmet, Feria, Zhang, Cheng, Oksvold, Per, Chen, Shuqi, Fagerberg, Linn, Uhlén, Mathias, Lindskog, Cecilia

“…One of the most complex organs in the human body is the testis, where spermatogenesis takes place. This physiological process involves thousands of genes and…”
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Initial Quantitative Proteomic Map of 28 Mouse Tissues Using the SILAC Mouse by Geiger, Tamar, Velic, Ana, Macek, Boris, Lundberg, Emma, Kampf, Caroline, Nagaraj, Nagarjuna, Uhlen, Mathias, Cox, Juergen, Mann, Matthias

“…Identifying the building blocks of mammalian tissues is a precondition for understanding their function. In particular, global and quantitative analysis of the…”
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Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast by Huang, Mingtao, Bai, Yunpeng, Sjostrom, Staffan L., Hallström, Björn M., Liu, Zihe, Petranovic, Dina, Uhlén, Mathias, Joensson, Haakan N., Andersson-Svahn, Helene, Nielsen, Jens

“…There is an increasing demand for biotech-based production of recombinant proteins for use as pharmaceuticals in the food and feed industry and in industrial…”
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Transcriptomics resources of human tissues and organs by Uhlén, Mathias, Hallström, Björn M, Lindskog, Cecilia, Mardinoglu, Adil, Pontén, Fredrik, Nielsen, Jens

“…Quantifying the differential expression of genes in various human organs, tissues, and cell types is vital to understand human physiology and disease…”
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CXCR4 and cancer by Furusato, Bungo, Mohamed, Ahmed, Uhlén, Mathias, Rhim, Johng S.

“…The chemokine receptor CXCR4 belongs to the large superfamily of G protein‐coupled receptors and has been identified to play a crucial role in a number of…”
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Growth of Cyanobacteria Is Constrained by the Abundance of Light and Carbon Assimilation Proteins by Jahn, Michael, Vialas, Vital, Karlsen, Jan, Maddalo, Gianluca, Edfors, Fredrik, Forsström, Björn, Uhlén, Mathias, Käll, Lukas, Hudson, Elton P.

“…Cyanobacteria must balance separate demands for energy generation, carbon assimilation, and biomass synthesis. We used shotgun proteomics to investigate…”
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Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy by Zandian, Arash, Forsström, Björn, Häggmark-Månberg, Anna, Schwenk, Jochen M, Uhlén, Mathias, Nilsson, Peter, Ayoglu, Burcu

“…The underlying molecular mechanisms of autoimmune diseases are poorly understood. To unravel the autoimmune processes across diseases, comprehensive and…”
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Spatiotemporal dissection of the cell cycle with single-cell proteogenomics by Mahdessian, Diana, Cesnik, Anthony J., Gnann, Christian, Danielsson, Frida, Stenström, Lovisa, Arif, Muhammad, Zhang, Cheng, Le, Trang, Johansson, Fredric, Schutten, Rutger, Bäckström, Anna, Axelsson, Ulrika, Thul, Peter, Cho, Nathan H., Carja, Oana, Uhlén, Mathias, Mardinoglu, Adil, Stadler, Charlotte, Lindskog, Cecilia, Ayoglu, Burcu, Leonetti, Manuel D., Pontén, Fredrik, Sullivan, Devin P., Lundberg, Emma

“…The cell cycle, over which cells grow and divide, is a fundamental process of life. Its dysregulation has devastating consequences, including cancer 1 – 3 …”
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Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues by Eraslan, Basak, Wang, Dongxue, Gusic, Mirjana, Prokisch, Holger, Hallström, Björn M, Uhlén, Mathias, Asplund, Anna, Pontén, Frederik, Wieland, Thomas, Hopf, Thomas, Hahne, Hannes, Kuster, Bernhard, Gagneur, Julien

“…Despite their importance in determining protein abundance, a comprehensive catalogue of sequence features controlling protein‐to‐mRNA (PTR) ratios and a…”
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