Search Results - "Uhl, Katie"

Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma by Uhl, Katie L, Schultz, Chad R, Geerts, Dirk, Bachmann, André S

“…Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid…”
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Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features by Bupp, Caleb P., Schultz, Chad R., Uhl, Katie L., Rajasekaran, Surender, Bachmann, André S.

“…The ornithine decarboxylase 1 (ODC1) gene plays an important role in physiological and cell developmental processes including embryogenesis, organogenesis, and…”
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Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model by Keele, Gregory R., Prokop, Jeremy W., He, Hong, Holl, Katie, Littrell, John, Deal, Aaron W., Kim, Yunjung, Kyle, Patrick B., Attipoe, Esinam, Johnson, Ashley C., Uhl, Katie L., Sirpilla, Olivia L., Jahanbakhsh, Seyedehameneh, Robinson, Melanie, Levy, Shawn, Valdar, William, Garrett, Michael R., Solberg Woods, Leah C.

“…Chronic kidney disease (CKD), which can ultimately progress to kidney failure, is influenced by genetics and the environment. Genes identified in human genome…”
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Integrated RNA Sequencing Reveals Epigenetic Impacts of Diesel Particulate Matter Exposure in Human Cerebral Organoids by Bilinovich, Stephanie M, Uhl, Katie L, Lewis, Kristy, Soehnlen, Xavier, Williams, Michael, Vogt, Daniel, Prokop, Jeremy W, Campbell, Daniel B

“…Autism spectrum disorder (ASD) manifests early in childhood. While genetic variants increase risk for ASD, a growing body of literature has established that in…”
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Genomic, transcriptomic, and protein landscape profile of CFTR and cystic fibrosis by Sanders, Morgan, Lawlor, James M. J., Li, Xiaopeng, Schuen, John N., Millard, Susan L., Zhang, Xi, Buck, Leah, Grysko, Bethany, Uhl, Katie L., Hinds, David, Stenger, Cynthia L., Morris, Michele, Lamb, Neil, Levy, Hara, Bupp, Caleb, Prokop, Jeremy W.

“…Cystic Fibrosis (CF) is caused most often by removal of amino acid 508 (Phe508del, deltaF508) within CFTR, yet dozens of additional CFTR variants are known to…”
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New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape by Schultz, Chad R, Sheldon, Ryan D, Xie, Huirong, Demireva, Elena Y, Uhl, Katie L, Agnew, Dalen W, Geerts, Dirk, Bachmann, André S

“…The eukaryotic translation initiation factor 5A1 (eIF5A1) and 5A2 (eIF5A2) are important proteins in a variety of physiological and pathophysiological…”
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Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19 by Prokop, Jeremy W, Shankar, Rama, Gupta, Ruchir, Leimanis, Mara L, Nedveck, Derek, Uhl, Katie, Chen, Bin, Hartog, Nicholas L, Van Veen, Jason, Sisco, Joshua S, Sirpilla, Olivia, Lydic, Todd, Boville, Brian, Hernandez, Angel, Braunreiter, Chi, Kuk, ChiuYing Cynthia, Singh, Varinder, Mills, Joshua, Wegener, Marc, Adams, Marie, Rhodes, Mary, Bachmann, Andre S, Pan, Wenjing, Byrne-Steele, Miranda L, Smith, D Casey, Depinet, Mollye, Brown, Brittany E, Eisenhower, Mary, Han, Jian, Haw, Marcus, Madura, Casey, Sanfilippo, Dominic J, Seaver, Laurie H, Bupp, Caleb, Rajasekaran, Surender

“…Precision medicine requires the translation of basic biological understanding to medical insights, mainly applied to characterization of each unique patient…”
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Emerging Role of ODC1 in Neurodevelopmental Disorders and Brain Development by Prokop, Jeremy W, Bupp, Caleb P, Frisch, Austin, Bilinovich, Stephanie M, Campbell, Daniel B, Vogt, Daniel, Schultz, Chad R, Uhl, Katie L, VanSickle, Elizabeth, Rajasekaran, Surender, Bachmann, André S

“…Ornithine decarboxylase 1 ( gene) has been linked through gain-of-function variants to a rare disease featuring developmental delay, alopecia, macrocephaly,…”
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Polyamine Biosynthetic Pathway as a Drug Target for Osteosarcoma Therapy by Weicht, Rebecca R, Schultz, Chad R, Geerts, Dirk, Uhl, Katie L, Bachmann, André S

“…Osteosarcoma (OS) is the most common bone tumor in children. Polyamines (PAs) are ubiquitous cations involved in many cell processes including tumor…”
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The complex, dynamic SpliceOme of the small GTPase transcripts altered by technique, sex, genetics, tissue specificity, and RNA base editing by Das, Akansha S, Sherry, Emily C, Vaughan, Robert M, Henderson, Marian L, Zieba, Jacob, Uhl, Katie L, Koehn, Olivia, Bupp, Caleb P, Rajasekaran, Surender, Li, Xiaopeng, Chhetri, Surya B, Nissim, Sahar, Williams, Carol L, Prokop, Jeremy W

“…The small GTPase family is well-studied in cancer and cellular physiology. With 162 annotated human genes, the family has a broad expression throughout cells…”
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NAA10 variant in 38-week-gestation male patient: a case study by Afrin, Antara, Prokop, Jeremy W, Underwood, Adam, Uhl, Katie L, VanSickle, Elizabeth A, Baruwal, Roja, Wajda, Morgan, Rajasekaran, Surender, Bupp, Caleb

“…We present a male patient born at 38-wk gestation with rhizomelic shortening of extremities, hepatomegaly, ventriculomegaly, heart failure, severely depressed…”
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Differential Transcriptomic Signatures of Small Airway Cell Cultures Derived from IPF and COVID-19-Induced Exacerbation of Interstitial Lung Disease by Uhl, Katie, Paithankar, Shreya, Leshchiner, Dmitry, Jager, Tara E, Abdelgied, Mohamed, Dixit, Bhavna, Marashdeh, Raya, Luo-Li, Dewen, Tripp, Kaylie, Peraino, Angela M, Tamae Kakazu, Maximiliano, Lawson, Cameron, Chesla, Dave W, Luo-Li, Ningzhi, Murphy, Edward T, Prokop, Jeremy, Chen, Bin, Girgis, Reda E, Li, Xiaopeng

“…Idiopathic pulmonary fibrosis (IPF) is a pathological condition wherein lung injury precipitates the deposition of scar tissue, ultimately leading to a decline…”
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Transcriptional analysis of the multiple Sry genes and developmental program at the onset of testis differentiation in the rat by Prokop, Jeremy W, Chhetri, Surya B, van Veen, J Edward, Chen, Xuqi, Underwood, Adam C, Uhl, Katie, Dwinell, Melinda R, Geurts, Aron M, Correa, Stephanie M, Arnold, Arthur P

“…The commonly used laboratory rat, Rattus norvegicus, is unique in having multiple Sry gene copies found on the Y chromosome, with different copies encoding…”
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Advanced Sequencing of Kidney Tubule Hypoxia Regulated Epithelial‐to‐Mesenchymal Transition by Prokop, Jeremy, Uhl, Katie, Kiryakoza, Morgan

“…Hypoxia is a known regulator of epithelial‐to‐mesenchymal transition in kidney tubule cells. However, culture systems have struggled to observe these…”
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Increased Expression of ATP12A in Small Airway Epithelia of Post-COVID-19 Pulmonary Fibrosis by Abdelgied, Mohamed, Zhou, Shan, Uhl, Katie, Jager, Tara, Lawson, Cameron, Chesla, David, Murphy, Edward, Li, Kun, Girgis, Reda E, Li, Xiaopeng

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Published anti-SARS-CoV-2 in vitro hits share common mechanisms of action that synergize with antivirals by Xing, Jing, Paithankar, Shreya, Liu, Ke, Uhl, Katie, Li, Xiaopeng, Ko, Meehyun, Kim, Seungtaek, Haskins, Jeremy, Chen, Bin

“…Abstract The global efforts in the past year have led to the discovery of nearly 200 drug repurposing candidates for COVID-19. Gaining more insights into their…”
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Abstract 1902: Potential role of DYRK family kinases in harmine-induced apoptosis in neuroblastoma by Uhl, Katie L., Schultz, Chad R., Geerts, Dirk, Bachmann, Andre S.

“…Abstract The purpose of this study was to determine the effect of the natural product Harmine in human neuroblastoma (NB). NB is an early childhood malignancy…”
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634: Acute and Recovery Phase Viral Bronchiolitis: Balancing Precision vs. Cohort Transcriptomic Analysis by Prokop, Jeremy, Leimanis, Mara, Gupta, Ruchir, Adams, Marie, Bachmann, Andre, Katie, Uhl, Bupp, Caleb, Hartog, Nicholas, Kort, Eric, Olivero, Rosemary, Sanfilippo, Dominic, Rajasekaran, Surender

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Targeting ATP12A, a Nongastric Proton Pump α Subunit, for Idiopathic Pulmonary Fibrosis Treatment by Abdelgied, Mohamed, Uhl, Katie, Chen, Oliver G, Schultz, Chad, Tripp, Kaylie, Peraino, Angela M, Paithankar, Shreya, Chen, Bin, Tamae Kakazu, Maximiliano, Castillo Bahena, Alicia, Jager, Tara E, Lawson, Cameron, Chesla, Dave W, Pestov, Nikolay, Modyanov, Nikolai N, Prokop, Jeremy, Neubig, Richard R, Uhal, Bruce D, Girgis, Reda E, Li, Xiaopeng

“…Idiopathic pulmonary fibrosis (IPF) is a pathological condition of unknown etiology that results from injury to the lung and an ensuing fibrotic response that…”
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Contributions of ATP12A, a non-gastric proton pump alpha subunit, to the pathogenesis of idiopathic pulmonary fibrosis by Li, Xiaopeng, Abdelgied, Mohamed, Uhl, Katie, Chen, Oliver, Schultz, Chad, Tripp, Kaylie, Peraino, Angela, Paithankar, Shreya, Chen, Bin, Tamae Kakazu, Maximiliano, Castillo Bahena, Alicia, Jager, Tara, Lawson, Cameron, Chesla, Dave, Pestov, Nikolay, Modyanov, Nikolai, Prokop, Jeremy, Neubig, Richard, Uhal, Bruce, Girgis, Reda

“…Abstract only Background: Idiopathic Pulmonary Fibrosis (IPF) is a pathological condition of unknown etiology which results from injury to the lung and an…”
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