Search Results - "Uhde, Almut"

Automated production of CCR5-negative CD4+-T cells in a GMP-compatible, clinical scale for treatment of HIV-positive patients by Schwarze, Lea Isabell, Sonntag, Tanja, Wild, Stefan, Schmitz, Sabrina, Uhde, Almut, Fehse, Boris

“…Ex-vivo gene editing in T lymphocytes paves the way for novel concepts of immunotherapy. One of those strategies is directed at the protection of CD4 + -T…”
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Deep Characterization and Comparison of Different Retrovirus-like Particles Preloaded with CRISPR/Cas9 RNPs by Wichmann, Max, Maire, Cecile L, Nuppenau, Niklas, Habiballa, Moataz, Uhde, Almut, Kolbe, Katharina, Schröder, Tanja, Lamszus, Katrin, Fehse, Boris, Głów, Dawid

“…The CRISPR/Cas system has a broad range of possible medical applications, but its clinical translation has been hampered, particularly by the lack of safe and…”
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Optimisation of a TALE nuclease targeting the HIV co-receptor CCR5 for clinical application by Schwarze, Lea Isabell, Głów, Dawid, Sonntag, Tanja, Uhde, Almut, Fehse, Boris

“…Disruption of the C-C-Chemokine-receptor-5 ( CCR5 ) gene induces resistance towards CCR5-tropic HIV. Here we optimised our previously described CCR5-Uco-TALEN…”
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Correction: Optimisation of a TALE nuclease targeting the HIV co-receptor CCR5 for clinical application by Schwarze, Lea Isabell, Głów, Dawid, Sonntag, Tanja, Uhde, Almut, Fehse, Boris

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Automated production of CCR5-negative CD4.sup.+-T cells in a GMP-compatible, clinical scale for treatment of HIV-positive patients by Schwarze, Lea Isabell, Sonntag, Tanja, Wild, Stefan, Schmitz, Sabrina, Uhde, Almut, Fehse, Boris

“…Ex-vivo gene editing in T lymphocytes paves the way for novel concepts of immunotherapy. One of those strategies is directed at the protection of CD4.sup.+-T…”
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CD45-Directed CAR-T Cells with CD45 Knockout Efficiently Kill Myeloid Leukemia and Lymphoma Cells In Vitro Even after Extended Culture by Harfmann, Maraike, Schröder, Tanja, Głów, Dawid, Jung, Maximilian, Uhde, Almut, Kröger, Nicolaus, Horn, Stefan, Riecken, Kristoffer, Fehse, Boris, Ayuk, Francis A

“…CAR-T cell therapy has shown impressive results and is now part of standard-of-care treatment of B-lineage malignancies, whereas the treatment of myeloid…”
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Efficient lentiviral transduction and transgene expression in primary human B cells by Mock, Ulrike, Thiele, Regine, Uhde, Almut, Fehse, Boris, Horn, Stefan

“…Primary human B cells are an attractive target for gene-therapeutic applications, but have been found to be relatively resistant toward transduction with…”
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High-Dose Multidrug Resistance in Primary Human Hematopoietic Progenitor Cells Transduced With Optimized Retroviral Vectors by Eckert, Hans-Georg, Stockschläder, Marcus, Just, Ursula, Hegewisch-Becker, Susanna, Grez, Manuel, Uhde, Almut, Zander, Axel, Ostertag, Wolfram, Baum, Christopher

“…Retroviral transfer of the multidrug-resistance 1 (mdr1) cDNA into primary human hematopoietic progenitor cells (HPC) of cancer patients undergoing high-dose…”
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Selective immunoaffinity-based enrichment of CD34+ cells transduced with retroviral vectors containing an intracytoplasmatically truncated version of the human low-affinity nerve growth factor receptor (deltaLNGFR) gene by Fehse, B, Uhde, A, Fehse, N, Eckert, H G, Clausen, J, Rüger, R, Koch, S, Ostertag, W, Zander, A R, Stockschläder, M

“…Human hematopoietic stem cells remain one of the most promising target cells for gene therapeutic approaches to treat malignant and nonmalignant diseases. To…”
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Highly‐efficient gene transfer with retroviral vectors into human T lymphocytes on fibronectin by Fehse, Boris, Schade, Ulrika M, LI, Zhixiong, Uhde, Almut, Koch, Stefan, Goller, Bernhard, RÜger, RÜdiger, Fehse, Natalia, StochschlÄder, Marcus, Zander, Axel R

“…Genetically modified lymphocytes have been successfully used for correction of ADA deficiency in children and in controlling graft‐versus‐host disease (GvHD)…”
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Improved retroviral vectors for hematopoietic stem cell protection and in vivo selection by Baum, C, Eckert, H G, Stockschläder, M, Just, U, Hegewisch-Becker, S, Hildinger, M, Uhde, A, John, J, Ostertag, W

“…Therapeutic gene transfer into hematopoietic cells is critically dependent on the evolution of methods that allow ex vivo expansion, high-frequency…”
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