Search Results - "Uhari‐Väänänen, Johanna"

Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model by Eteläinen, Tony S., Kilpeläinen, Tommi P., Ignatius, Adele, Auno, Samuli, De Lorenzo, Francesca, Uhari-Väänänen, Johanna K., Julku, Ulrika H., Myöhänen, Timo T.

“…Parkinson's disease (PD) is characterized by degeneration of nigrostriatal dopaminergic neurons and accumulation of α-synuclein (αSyn) as Lewy bodies…”
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5‑Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions by Pätsi, Henri T., Kilpeläinen, Tommi P., Jumppanen, Mikael, Uhari-Väänänen, Johanna, Wielendaele, Pieter Van, De Lorenzo, Francesca, Cui, Hengjing, Auno, Samuli, Saharinen, Janne, Seppälä, Erin, Sipari, Nina, Savinainen, Juha, De Meester, Ingrid, Lambeir, Anne-Marie, Lahtela-Kakkonen, Maija, Myöhänen, Timo T., Wallén, Erik A. A.

“…A series of novel 5-aminothiazole-based ligands for prolyl oligopeptidase (PREP) comprise selective, potent modulators of the protein–protein interaction…”
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A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy by Eteläinen, Tony S, Silva, M Catarina, Uhari-Väänänen, Johanna K, De Lorenzo, Francesca, Jäntti, Maria H, Cui, Hengjing, Chavero-Pieres, Marta, Kilpeläinen, Tommi, Mechtler, Christina, Svarcbahs, Reinis, Seppälä, Erin, Savinainen, Juha R, Puris, Elena, Fricker, Gert, Gynther, Mikko, Julku, Ulrika H, Huttunen, Henri J, Haggarty, Stephen J, Myöhänen, Timo T

“…Tauopathies are neurodegenerative diseases that are characterized by accumulation of hyperphosphorylated tau protein, higher-order aggregates, and tau…”
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Accumbal μ-Opioid Receptors Modulate Ethanol Intake in Alcohol-Preferring Alko Alcohol Rats by Uhari-Väänänen, Johanna, Raasmaja, Atso, Bäckström, Pia, Oinio, Ville, Airavaara, Mikko, Piepponen, Petteri, Kiianmaa, Kalervo

“…Background The nucleus accumbens shell is a key brain area mediating the reinforcing effects of ethanol (EtOH). Previously, it has been shown that the density…”
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Dopaminergic modulation of reward-guided decision making in alcohol-preferring AA rats by Oinio, Ville, Bäckström, Pia, Uhari-Väänänen, Johanna, Raasmaja, Atso, Piepponen, Petteri, Kiianmaa, Kalervo

“…•d-Amphetamine acts as a promoter of irrational and unprofitable decision making.•Restricted feeding might mask the anorexic effects of dopaminergic drugs.•AA…”
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The selective κ-opioid receptor antagonist JDTic attenuates the alcohol deprivation effect in rats by Uhari-Väänänen, Johanna, Eteläinen, Tony, Bäckström, Pia, Oinio, Ville, Carroll, F. Ivy, Raasmaja, Atso, Kiianmaa, Kalervo, Piepponen, Petteri

“…•Systemic and intra-accumbens shell JDTic, a κ-antagonist, attenuated the ADE in rats.•A low dose of naltrexone inhibited the ADE and decreased ethanol…”
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The role of opioidergic system in modulating cost/benefit decision-making in alcohol-preferring AA rats and Wistar rats by Oinio, Ville, Sundström, Mikko, Bäckström, Pia, Uhari-Väänänen, Johanna, Kiianmaa, Kalervo, Raasmaja, Atso, Piepponen, Petteri

“…Research has highlighted the association of a positive family history of alcoholism with a positive treatment response to opioid antagonists in those with a…”
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Amphetamine primes enhanced motivation toward uncertain choices in rats with genetic alcohol preference by Oinio, Ville, Sundström, Mikko, Bäckström, Pia, Uhari-Väänänen, Johanna, Kiianmaa, Kalervo, Raasmaja, Atso, Piepponen, Petteri

“…Rationale Comorbidity with gambling disorder (GD) and alcohol use disorder (AUD) is well documented. Objective The purpose of our study was to examine the…”
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The κ-opioid receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats by Uhari-Väänänen, Johanna, Raasmaja, Atso, Bäckström, Pia, Oinio, Ville, Carroll, F. Ivy, Airavaara, Mikko, Kiianmaa, Kalervo, Piepponen, Petteri

“…Rationale Studies suggest that the κ-opioidergic system becomes overactivated as ethanol use disorders develop. Nalmefene, a currently approved treatment for…”
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Novel Small‐Molecular Ligands for Prolyl Oligopeptidase to Combat Tauopathies by Eteläinen, Tony, Pätsi, Henri, Uhari‐Väänänen, Johanna, Aikkila, Hannes, Cui, Hengjing, De Lorenzo, Francesca, Kilpeläinen, Tommi, Julku, Ulrika, Wallén, Erik A.A., Myöhänen, Timo T

“…Background Tauopathies that include e.g. frontotemporal dementia and Alzheimer’s disease, are neurodegenerative diseases characterized by accumulation of…”
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The [kappa]-opioid receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats by Uhari-Väänänen, Johanna, Raasmaja, Atso, Bäckström, Pia, Oinio, Ville, Carroll, F. Ivy, Airavaara, Mikko, Kiianmaa, Kalervo

“…Rationale Studies suggest that the [kappa]-opioidergic system becomes overactivated as ethanol use disorders develop. Nalmefene, a currently approved treatment…”
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