Potentiating effect of Bay K 8644 on agonist-induced ileal contractions

The effects of Bay K 8644 on agonist-induced ileal contractions were investigated. Histamine, serotonin and a acetylcholine (10(-8)-10(-4) M) produced a dose-dependent contraction. Maximum contraction was obtained by 10(-5) M serotonin. Its value was 1076 mg. Bay K 8644 (10(-6) M) increased the pote...

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Bibliographic Details
Published in:	Polish journal of pharmacology Vol. 45; no. 4; p. 413
Main Authors:	Gacar, N M, Kalyoncu, N I, Aksoy, Z, Sivrikaya, N, Ugurbas, O, Mollaoglu, A H, Caglar, M
Format:	Journal Article
Language:	English
Published:	Poland 01-07-1993
Subjects:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Acetylcholine - pharmacology Animals Calcium Channels - drug effects Calcium Channels - metabolism Dose-Response Relationship, Drug Drug Interactions Female Guinea Pigs Histamine - pharmacology Ileum - drug effects Ileum - physiology In Vitro Techniques Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Nifedipine - pharmacology Serotonin - pharmacology
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Summary:	The effects of Bay K 8644 on agonist-induced ileal contractions were investigated. Histamine, serotonin and a acetylcholine (10(-8)-10(-4) M) produced a dose-dependent contraction. Maximum contraction was obtained by 10(-5) M serotonin. Its value was 1076 mg. Bay K 8644 (10(-6) M) increased the potency of histamine and serotonin-induced ileal contractions, but acetylcholine induced responses were not increased. All responses of agonists were inhibited by nifedipine (10(-6) M). This inhibition was decreased with increasing acetylcholine concentrations. These results suggest that histamine and serotonin induced/mediated contractions in guinea-pig ileum are independent of calcium influx through voltage operated channels.
ISSN:	1230-6002