Search Results - "Ugolini, Annarosa"

Group I metabotropic glutamate receptors: implications for brain diseases by Bordi, F, Ugolini, A

“…Glutamate is the major excitatory neurotransmitter in the brain and plays a unique role in a variety of central nervous system (CNS) functions. The discovery…”
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Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity by Sakurai, Fumie, Yukawa, Takafumi, Kina, Asato, Murakami, Masataka, Takami, Kazuaki, Morimoto, Sachie, Seto, Masaki, Kamata, Makoto, Yamashita, Tohru, Nakashima, Kosuke, Narita, Naohiro, Bettini, Ezio, Ugolini, Annarosa, Corsi, Mauro, Hasui, Tomoaki

“…[Display omitted] N-Methyl-d-aspartate receptors (NMDARs) are members of the ionotropic glutamate receptor family and play a crucial role in learning and…”
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Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment by Yukawa, Takafumi, Yamashita, Tohru, Imaeda, Toshihiro, Kakei, Hiroyuki, Hashizume, Shogo, Nakamura, Minoru, Daini, Masaki, Okabe, Atsutoshi, Nakashima, Kosuke, Harada, Akina, Narita, Naohiro, Bettini, Ezio, Ugolini, Annarosa, Corsi, Mauro, Hasui, Tomoaki

“…[Display omitted] N-Methyl-D-aspartate receptors (NMDARs) are key regulators of synaptic plasticity in the central nervous system. Potentiation of NMDARs…”
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S223. COMBINED TREATMENT WITH A SELECTIVE PDE10A INHIBITOR TAK-063 AND ANTIPSYCHOTICS AT SUBEFFECTIVE DOSES PRODUCES POTENT ANTIPSYCHOTIC-LIKE EFFECTS WITHOUT EXACERBATING SIDE EFFECTS PROFILE IN RODENTS by Suzuki, Kazunori, Harada, Akina, Suzuki, Hirobumi, Nakatani, Atsushi, Capuani, Clizia, Ugolini, Annarosa, Corsi, Mauro, Kaushal, Nidhi, Bobkov, Konstantin, Vekich, John, Doyle, Joseph, Kimura, Haruhide

“…Abstract Background Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action (MOA) of…”
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Chronic stress-induced alterations in amygdala responsiveness and behavior - modulation by trait anxiety and corticotropin-releasing factor systems by Sandi, Carmen, Cordero, M. Isabel, Ugolini, Annarosa, Varea, Emilio, Caberlotto, Laura, Large, Charles H.

“…The basolateral nucleus of the amygdala (BLA) plays a key role in emotional arousal and anxiety, and expresses high levels of corticotropin‐releasing factor…”
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Spontaneous cardiac action potentials recordings from human cardiomyocytes derived from pluripotent stem cells: An experimental paradigm in agreement with CiPA recommendation by Virginio, Caterina, Ugolini, Annarosa, Ballini, Elisa, Carignani, Corrado, Corsi, Mauro

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Can a pro-seizure effect be predicted? Evaluation of two technological approaches in hippocampal slices by Ugolini, Annarosa, Maccione, Alessandro, Gandolfo, Mauro, Corsi, Mauro, Virginio, Caterina

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Combined treatment with a selective PDE10A inhibitor TAK‐063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic‐like effects without affecting plasma prolactin levels and cataleptic responses in rodents by Suzuki, Kazunori, Harada, Akina, Suzuki, Hirobumi, Capuani, Clizia, Ugolini, Annarosa, Corsi, Mauro, Kimura, Haruhide

“…Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal mechanism of action of current antipsychotics with…”
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AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala by Ugolini, Annarosa, Large, Charles H, Corsi, Mauro

“…Glutamatergic neurotransmission has been implicated in the pathophysiology of psychiatric disorders, such as anxiety and depression. The possible contribution…”
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AMN082, an allosteric mGluR 7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala by Ugolini, Annarosa, Large, Charles H., Corsi, Mauro

“…Glutamatergic neurotransmission has been implicated in the pathophysiology of psychiatric disorders, such as anxiety and depression. The possible contribution…”
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Optimisation of an integrated strategy to assess convulsion/seizure risk of novel compounds by Virginio, Caterina, Ugolini, Annarosa, Siri, Marcelo Rosato, Fasdelli, Nicola, Guidi, Alessia, Rostello, Chiara, Poffe, Alessandro, Gerrard, Philip, Corsi, Mauro, Pilla, Maria

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Transient forebrain over-expression of CRF induces plasma corticosterone and mild behavioural changes in adult conditional CRF transgenic mice by Vicentini, Elena, Arban, Roberto, Angelici, Ornella, Maraia, Gabriella, Perico, MariaElisa, Mugnaini, Manolo, Ugolini, Annarosa, Large, Charles, Domenici, Enrico, Gerrard, Philip, Bortner, Donna, Mansuy, Isabelle M., Mangiarini, Laura, Merlo-Pich, Emilio

“…Converging findings support a role for extra-hypothalamic CRF in the mediation of the stress response. The influence of CRF in the amygdala is well…”
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The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2 by D’Alessandro, Pier L., Corti, Corrado, Roth, Adelheid, Ugolini, Annarosa, Sava, Anna, Montanari, Dino, Bianchi, Federica, Garland, Stephen L., Powney, Ben, Koppe, Emma L., Rocheville, Magalie, Osborne, Greg, Perez, Paloma, de la Fuente, Jesús, De Los Frailes, Maite, Smith, Paul W., Branch, Clive, Nash, David, Watson, Stephen P.

“…The optimisation of an HTS hit series ( 1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 positive modulators…”
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CRF1 receptor activation increases the response of neurons in the basolateral nucleus of the amygdala to afferent stimulation by Ugolini, Annarosa, Sokal, David M, Arban, Roberto, Large, Charles H

“…The basolateral nucleus (BLA) of the amygdala contributes to the consolidation of memories for emotional or stressful events. The nucleus contains a high…”
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Involvement of mGluR 5 on acute nociceptive transmission by Bordi, Fabio, Ugolini, Annarosa

“…The effect of the mGluR 5 antagonist, MPEP (2-Methyl-6-(phenylethynyl)-pyridine), and of the mGluR 1 antagonist, AIDA(( RS)-1-Aminoindan-1,5-dicarboxylic…”
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Involvement of mGluR5 on acute nociceptive transmission by BORDI, F, UGOLINI, A

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Synthesis and pharmacological characterisation of 2,4-Dicarboxy-pyrroles as selective non-Competitive mGluR1 antagonists by Micheli, Fabrizio, Fabio, Romano Di, Cavanni, Paolo, Rimland, Joseph M, Capelli, Anna Maria, Chiamulera, Cristiano, Corsi, Mauro, Corti, Corrado, Donati, Daniele, Feriani, Aldo, Ferraguti, Francesco, Maffeis, Micaela, Missio, Andrea, Ratti, Emiliangelo, Paio, Alfredo, Pachera, Roberta, Quartaroli, Mauro, Reggiani, Angelo, Sabbatini, Fabio Maria, Trist, David G, Ugolini, Annarosa, Vitulli, Giovanni

“…Metabotropic glutamate receptors (mGluRs) are an unusual family of G-protein coupled receptor (GPCR), and are characterised by a large extracellular N-terminal…”
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Metabotropic glutamate group II receptors are responsible for the depression of synaptic transmission induced by ACPD in the dentate gyrus by Ugolini, Annarosa, Bordi, Fabio

“…The functional role of metabotropic glutamate (mGlu) receptors in the rat dentate gyrus was investigated. By using extracellular recording techniques in…”
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Effects of metabotropic glutamate receptors antagonists on the synaptic transmission in the rat hippocampal slices by Bordi, Fabio, Ugolini, Annarosa

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Antagonists of the metabotropic glutamate receptor do not prevent induction of long-term potentiation in the dentate gyrus of rats by Bordi, Fabio, Ugolini, Annarosa

“…The effects of two competitive metabotropic glutamate (mGlu) receptor antagonists, ( RS)-α-methyl-4-carboxyphenylglycine (MCPG) and (…”
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