Search Results - "Ugo Pastorino"

Clinical Utility of a Plasma-Based miRNA Signature Classifier Within Computed Tomography Lung Cancer Screening: A Correlative MILD Trial Study by SOZZI, Gabriella, BOERI, Mattia, MARCHIANO, Alfonso, NEGRI, Eva, LA VECCHIA, Carlo, PASTORINO, Ugo, ROSSI, Marta, VERRI, Carla, SUATONI, Paola, BRAVI, Francesca, ROZ, Luca, CONTE, Davide, GRASSI, Michela, SVERZELLATI, Nicola

“…Recent screening trial results indicate that low-dose computed tomography (LDCT) reduces lung cancer mortality in high-risk patients. However, high…”
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European position statement on lung cancer screening by Oudkerk, Matthijs, Devaraj, Anand, Vliegenthart, Rozemarijn, Henzler, Thomas, Prosch, Helmut, Heussel, Claus P, Bastarrika, Gorka, Sverzellati, Nicola, Mascalchi, Mario, Delorme, Stefan, Baldwin, David R, Callister, Matthew E, Becker, Nikolaus, Heuvelmans, Marjolein A, Rzyman, Witold, Infante, Maurizio V, Pastorino, Ugo, Pedersen, Jesper H, Paci, Eugenio, Duffy, Stephen W, de Koning, Harry, Field, John K

“…Lung cancer screening with low-dose CT can save lives. This European Union (EU) position statement presents the available evidence and the major issues that…”
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Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors by George, Julie, Walter, Vonn, Peifer, Martin, Alexandrov, Ludmil B., Seidel, Danila, Leenders, Frauke, Maas, Lukas, Müller, Christian, Dahmen, Ilona, Delhomme, Tiffany M., Ardin, Maude, Leblay, Noemie, Byrnes, Graham, Sun, Ruping, De Reynies, Aurélien, McLeer-Florin, Anne, Bosco, Graziella, Malchers, Florian, Menon, Roopika, Altmüller, Janine, Becker, Christian, Nürnberg, Peter, Achter, Viktor, Lang, Ulrich, Schneider, Peter M., Bogus, Magdalena, Soloway, Matthew G., Wilkerson, Matthew D., Cun, Yupeng, McKay, James D., Moro-Sibilot, Denis, Brambilla, Christian G., Lantuejoul, Sylvie, Lemaitre, Nicolas, Soltermann, Alex, Weder, Walter, Tischler, Verena, Brustugun, Odd Terje, Lund-Iversen, Marius, Helland, Åslaug, Solberg, Steinar, Ansén, Sascha, Wright, Gavin, Solomon, Benjamin, Roz, Luca, Pastorino, Ugo, Petersen, Iver, Clement, Joachim H., Sänger, Jörg, Wolf, Jürgen, Vingron, Martin, Zander, Thomas, Perner, Sven, Travis, William D., Haas, Stefan A., Olivier, Magali, Foll, Matthieu, Büttner, Reinhard, Hayes, David Neil, Brambilla, Elisabeth, Fernandez-Cuesta, Lynnette, Thomas, Roman K.

“…Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we…”
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MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer by Boeri, Mattia, Verri, Carla, Conte, Davide, Roz, Luca, Modena, Piergiorgio, Facchinetti, Federica, Calabrò, Elisa, Croce, Carlo M, Pastorino, Ugo, Sozzi, Gabriella

“…The efficacy of computed tomography (CT) screening for early lung cancer detection in heavy smokers is currently being tested by a number of randomized trials…”
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Lung cancer screening by nodule volume in Lung-RADS v1.1: negative baseline CT yields potential for increased screening interval by Silva, Mario, Milanese, Gianluca, Sestini, Stefano, Sabia, Federica, Jacobs, Colin, van Ginneken, Bram, Prokop, Mathias, Schaefer-Prokop, Cornelia M., Marchianò, Alfonso, Sverzellati, Nicola, Pastorino, Ugo

“…Objectives The 2019 Lung CT Screening Reporting & Data System version 1.1 (Lung-RADS v1.1) introduced volumetric categories for nodule management. The aims of…”
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Randomized Phase III Study of Surgery Alone or Surgery Plus Preoperative Cisplatin and Gemcitabine in Stages IB to IIIA Non–Small-Cell Lung Cancer by SCAGLIOTTI, Giorgio V, PASTORINO, Ugo, TORRI, Valter, VANSTEENKISTE, Johan F, SPAGGIARI, Lorenzo, FACCIOLO, Francesco, ORLOWSKI, Tadeusz M, MAIORINO, Luigi, HETZEL, Martin, LESCHINGER, Monika, VISSEREN-GRUL, Carla

“…This study aimed to determine whether three preoperative cycles of gemcitabine plus cisplatin followed by radical surgery provides a reduction in the risk of…”
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Highly tumorigenic lung cancer CD133⁺ cells display stem-like features and are spared by cisplatin treatment by Bertolini, Giulia, Roz, Luca, Perego, Paola, Tortoreto, Monica, Fontanella, Enrico, Gatti, Laura, Pratesi, Graziella, Fabbri, Alessandra, Andriani, Francesca, Tinelli, Stella, Roz, Elena, Caserini, Roberto, Lo Vullo, Salvatore, Camerini, Tiziana, Mariani, Luigi, Delia, Domenico, Calabrò, Elisa, Pastorino, Ugo, Sozzi, Gabriella

“…The identification of lung tumor-initiating cells and associated markers may be useful for optimization of therapeutic approaches and for predictive and…”
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C-reactive protein level predicts mortality in COPD: a systematic review and meta-analysis by Leuzzi, Giovanni, Galeone, Carlotta, Taverna, Francesca, Suatoni, Paola, Morelli, Daniele, Pastorino, Ugo

“…The prognostic role of baseline C-reactive protein (CRP) in chronic obstructive pulmonary disease (COPD) is controversial. In order to clarify this issue, we…”
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Routine perioperative blood tests predict survival of resectable lung cancer by Morelli, Daniele, Cantarutti, Anna, Valsecchi, Camilla, Sabia, Federica, Rolli, Luigi, Leuzzi, Giovanni, Bogani, Giorgio, Pastorino, Ugo

“…There is growing evidence that inflammatory, immunologic, and metabolic status is associated with cancer patients survival. Here, we built a simple algorithm…”
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Novel method to detect microRNAs using chip-based QuantStudio 3D digital PCR by Conte, Davide, Verri, Carla, Borzi, Cristina, Suatoni, Paola, Pastorino, Ugo, Sozzi, Gabriella, Fortunato, Orazio

“…Research efforts for the management of cancer, in particular for lung cancer, are directed to identify new strategies for its early detection. MicroRNAs…”
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Establishment of patient derived xenografts as functional testing of lung cancer aggressiveness by Moro, Massimo, Bertolini, Giulia, Caserini, Roberto, Borzi, Cristina, Boeri, Mattia, Fabbri, Alessandra, Leone, Giorgia, Gasparini, Patrizia, Galeone, Carlotta, Pelosi, Giuseppe, Roz, Luca, Sozzi, Gabriella, Pastorino, Ugo

“…Despite many years of research efforts, lung cancer still remains the leading cause of cancer deaths worldwide. Objective of this study was to set up a…”
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Indolent Adenocarcinoma In Situ Mistaken as Aggressive during Lung Cancer Screening Program: To Heal or to Harm? by Orlandi, Riccardo, Mattioni, Giovanni, Rolli, Luigi, Pastorino, Ugo

“…Background: Low-dose computed tomography-based lung cancer screening (LCS) has demonstrated efficacy in reducing lung cancer mortality. However, concerns about…”
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Fully automated calcium scoring predicts all-cause mortality at 12 years in the MILD lung cancer screening trial by Sabia, Federica, Balbi, Maurizio, Ledda, Roberta E, Milanese, Gianluca, Ruggirello, Margherita, Valsecchi, Camilla, Marchianò, Alfonso, Sverzellati, Nicola, Pastorino, Ugo

“…Coronary artery calcium (CAC) is a known risk factor for cardiovascular (CV) events and mortality but is not yet routinely evaluated in low-dose computed…”
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Early Effector T Lymphocytes Coexpress Multiple Inhibitory Receptors in Primary Non-Small Cell Lung Cancer by Tassi, Elena, Grazia, Giulia, Vegetti, Claudia, Bersani, Ilaria, Bertolini, Giulia, Molla, Alessandra, Baldassari, Paola, Andriani, Francesca, Roz, Luca, Sozzi, Gabriella, Pastorino, Ugo, Mortarini, Roberta, Anichini, Andrea

“…Clinical efficacy of PD-1/PD-L1 targeting relies upon the reactivation of tumor-specific but functionally impaired PD-1 T cells present before therapy. Thus,…”
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Diagnostic role of circulating extracellular matrix-related proteins in non-small cell lung cancer by Andriani, Francesca, Landoni, Elena, Mensah, Mavis, Facchinetti, Federica, Miceli, Rosalba, Tagliabue, Elda, Giussani, Marta, Callari, Maurizio, De Cecco, Loris, Colombo, Mario Paolo, Roz, Luca, Pastorino, Ugo, Sozzi, Gabriella

“…Interactions between cancer cells and the surrounding microenvironment are crucial determinants of cancer progression. During this process, bi-directional…”
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Baseline and postoperative C-reactive protein levels predict mortality in operable lung cancer by Pastorino, Ugo, Morelli, Daniele, Leuzzi, Giovanni, Gisabella, Mara, Suatoni, Paola, Taverna, Francesca, Bertocchi, Elena, Boeri, Mattia, Sozzi, Gabriella, Cantarutti, Anna, Corrao, Giovanni

“…Abstract Background Higher blood levels of C-reactive protein (CRP) have been associated with shorter survival in patients with cardiovascular, chronic…”
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CXCR4 Inhibition Counteracts Immunosuppressive Properties of Metastatic NSCLC Stem Cells by Fortunato, Orazio, Belisario, Dimas Carolina, Compagno, Mara, Giovinazzo, Francesca, Bracci, Cristiano, Pastorino, Ugo, Horenstein, Alberto, Malavasi, Fabio, Ferracini, Riccardo, Scala, Stefania, Sozzi, Gabriella, Roz, Luca, Roato, Ilaria, Bertolini, Giulia

“…Cancer stem cells (CSCs) are functionally defined as the cell subset with greater potential to initiate and propagate tumors. Within the heterogeneous…”
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Assessment of circulating microRNAs in plasma of lung cancer patients by Fortunato, Orazio, Boeri, Mattia, Verri, Carla, Conte, Davide, Mensah, Mavis, Suatoni, Paola, Pastorino, Ugo, Sozzi, Gabriella

“…Lung cancer is the most common cause of cancer deaths worldwide and numerous ongoing research efforts are directed to identify new strategies for its early…”
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Cotargeting of miR‐126‐3p and miR‐221‐3p inhibits PIK3R2 and PTEN, reducing lung cancer growth and metastasis by blocking AKT and CXCR4 signalling by Di Paolo, Daniela, Pontis, Francesca, Moro, Massimo, Centonze, Giovanni, Bertolini, Giulia, Milione, Massimo, Mensah, Mavis, Segale, Miriam, Petraroia, Ilaria, Borzi, Cristina, Suatoni, Paola, Brignole, Chiara, Perri, Patrizia, Ponzoni, Mirco, Pastorino, Ugo, Sozzi, Gabriella, Fortunato, Orazio

“…Lung cancer is the leading cause of cancer‐related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since…”
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Extracellular vesicles from subjects with COPD modulate cancer initiating cells phenotype through HIF-1α shuttling by Petraroia, Ilaria, Ghidotti, Patrizia, Bertolini, Giulia, Pontis, Francesca, Roz, Luca, Balsamo, Melissa, Suatoni, Paola, Pastorino, Ugo, Ferretti, Anna Maria, Sozzi, Gabriella, Fortunato, Orazio

“…Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development. COPD induces activation of hypoxia-induced signaling, causing…”
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