Search Results - "Ugen, Kenneth"

Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease by Shahaduzzaman, Md, Nash, Kevin, Hudson, Charles, Sharif, Masroor, Grimmig, Bethany, Lin, Xiaoyang, Bai, Ge, Liu, Hui, Ugen, Kenneth E, Cao, Chuanhai, Bickford, Paula C

“…The protein α-synuclein (α-Syn) has a central role in the pathogenesis of Parkinson's disease (PD) and immunotherapeutic approaches targeting this molecule…”
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A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates by Muthumani, Karuppiah, Falzarano, Darryl, Reuschel, Emma L, Tingey, Colleen, Flingai, Seleeke, Villarreal, Daniel O, Wise, Megan, Patel, Ami, Izmirly, Abdullah, Aljuaid, Abdulelah, Seliga, Alecia M, Soule, Geoff, Morrow, Matthew, Kraynyak, Kimberly A, Khan, Amir S, Scott, Dana P, Feldmann, Friederike, LaCasse, Rachel, Meade-White, Kimberly, Okumura, Atsushi, Ugen, Kenneth E, Sardesai, Niranjan Y, Kim, J Joseph, Kobinger, Gary, Feldmann, Heinz, Weiner, David B

“…First identified in 2012, Middle East respiratory syndrome (MERS) is caused by an emerging human coronavirus, which is distinct from the severe acute…”
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Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma by DAUD, Adil I, DECONTI, Ronald C, HELLER, Richard, ANDREWS, Stephanie, URBAS, Patricia, RIKER, Adam I, SONDAK, Vernon K, MUNSTER, Pamela N, SULLIVAN, Daniel M, UGEN, Kenneth E, MESSINA, Jane L

“…Gene-based immunotherapy for cancer is limited by the lack of safe, efficient, reproducible, and titratable delivery methods. Direct injection of DNA into…”
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A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus by Choi, Hyeree, Kudchodkar, Sagar B, Ho, Michelle, Reuschel, Emma L, Reynolds, Erin, Xu, Ziyang, Bordoloi, Devivasha, Ugen, Kenneth E, Tebas, Pablo, Kim, Joseph, Abdel-Mohsen, Mohamed, Thangamani, Saravanan, Weiner, David B, Muthumani, Kar

“…Powassan virus (POWV) infection is a tick-borne emerging infectious disease in the United States and North America. Like Zika virus, POWV is a member of the…”
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Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus by Muthumani, Karuppiah, Block, Peter, Flingai, Seleeke, Muruganantham, Nagarajan, Chaaithanya, Itta Krishna, Tingey, Colleen, Wise, Megan, Reuschel, Emma L., Chung, Christopher, Muthumani, Abirami, Sarangan, Gopalsamy, Srikanth, Padma, Khan, Amir S., Vijayachari, Paluru, Sardesai, Niranjan Y., Kim, J. Joseph, Ugen, Kenneth E., Weiner, David B.

“…Background. Vaccination and passive antibody therapies are critical for controlling infectious diseases. Passive antibody administration has limitations,…”
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Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody by Muthumani, Kar, Marnin, Liron, Kudchodkar, Sagar B., Perales-Puchalt, Alfredo, Choi, Hyeree, Agarwal, Sangya, Scott, Veronica L., Reuschel, Emma L., Zaidi, Faraz I., Duperret, Elizabeth K., Wise, Megan C., Kraynyak, Kimberly A., Ugen, Kenneth. E., Sardesai, Niranjan Y., Joseph Kim, J., Weiner, David B.

“…Prostate-specific membrane antigen (PSMA) is expressed at high levels on malignant prostate cells and is likely an important therapeutic target for the…”
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Neutralization of hepatitis B virus by a novel DNA-encoded monoclonal antibody by Zankharia, Urvi S., Kudchodkar, Sagar, Khoshnejad, Makan, Perales-Puchalt, Alfredo, Choi, Hyeree, Ho, Michelle, Zaidi, Faraz, Ugen, Kenneth E., Kim, Joseph J., Weiner, David B., Muthumani, Kar

“…Hepatitis B virus (HBV) causes a potentially life-threatening liver infection that frequently results in life-long chronic infection. HBV is responsible for…”
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In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine by Muthumani, Karuppiah, Griffin, Bryan D, Agarwal, Sangya, Kudchodkar, Sagar B, Reuschel, Emma L, Choi, Hyeree, Kraynyak, Kimberly A, Duperret, Elizabeth K, Keaton, Amelia Anne, Chung, Christopher, Kim, Yinho K, Booth, Stephanie A, Racine, Trina, Yan, Jian, Morrow, Matthew P, Jiang, Jingjing, Lee, Brian, Ramos, Stephanie, Broderick, Kate E, Reed, Charles C, Khan, Amir S, Humeau, Laurent, Ugen, Kenneth E, Park, Young K, Maslow, Joel N, Sardesai, Niranjan Y, Joseph Kim, J, Kobinger, Gary P, Weiner, David B

“…Significant concerns have been raised owing to the rapid global spread of infection and disease caused by the mosquito-borne Zika virus (ZIKV). Recent studies…”
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Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab by Muthumani, Kar, Flingai, Seleeke, Wise, Megan, Tingey, Colleen, Ugen, Kenneth E, Weiner, David B

“…Monoclonal antibody preparations have demonstrated considerable clinical utility in the treatment of specific malignancies, as well as inflammatory and…”
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Evaluation of an α synuclein sensitized dendritic cell based vaccine in a transgenic mouse model of Parkinson disease by Ugen, Kenneth E, Lin, Xiaoyang, Bai, Ge, Liang, Zhanhua, Cai, Jianfeng, Li, Kunyun, Song, Shijie, Cao, Chuanhai, Sanchez-Ramos, Juan

“…In order to develop a cell-based vaccine against the Parkinson disease (PD) associated protein α-synuclein (α-Syn) 3 peptides were synthesized based upon…”
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Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease by Morgan, Dave, Diamond, David M, Gottschall, Paul E, Ugen, Kenneth E, Dickey, Chad, Hardy, John, Duff, Karen, Jantzen, Paul, DiCarlo, Giovanni, Wilcock, Donna, Connor, Karen, Hatcher, Jaime, Hope, Caroline, Gordon, Marcia, Arendash, Gary W

“…Vaccinations with amyloid-β peptide (AB) can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease. To determine if the…”
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Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration by Wilcock, Donna M, Munireddy, Sanjay K, Rosenthal, Arnon, Ugen, Kenneth E, Gordon, Marcia N, Morgan, Dave

“…The mechanisms by which anti-Aβ antibodies clear amyloid plaques in Aβ depositing transgenic mice are unclear. In the current study, we demonstrate that…”
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Synthetic nucleic acid antibody prophylaxis confers rapid and durable protective immunity against Zika virus challenge by Choi, Hyeree, Kudchodkar, Sagar B., Reuschel, Emma L., Asija, Kanika, Borole, Piyush, Agarwal, Sangya, Van Gorder, Lucas, Reed, Charles C., Gulendran, Gayathri, Ramos, Stephanie, Broderick, Kate E., Kim, J Joseph, Ugen, Kenneth E., Kobinger, Gary, Siegel, Don L., Weiner, David B., Muthumani, Kar

“…Significant concerns have arisen over the past 3 y from the increased global spread of the mosquito-borne flavivirus, Zika. Accompanying this spread has been…”
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Gene-based vaccines and immunotherapeutic strategies against neurodegenerative diseases: Potential utility and limitations by Kudrna, Jeremy J, Ugen, Kenneth E

“…There has been a recent expansion of vaccination and immunotherapeutic strategies from controlling infectious diseases to the targeting of non-infectious…”
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Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-Aβ antibodies by Li, Qingyou, Gordon, Marcia, Cao, Chuanhai, Ugen, Kenneth E, Morgan, Dave

“…Abstract Background Prior work from our group found that acid dissociation (pH 2.5 incubation) of serum from APP transgenic mice vaccinated against Aβ…”
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Review of Gene Vaccines book by Ugen, Kenneth E

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Protocols for Developing Novel Chikungunya Virus DNA Vaccines by Chung, Christopher, Ugen, Kenneth E, Sardesai, Niranjan Y, Weiner, David B, Muthumani, Kar

“…To date, there have been several million infections by the Chikungunya virus (CHIKV), a mosquito-transmitted emerging pathogen that is considered to be…”
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DNA Vaccines against Human Immunodeficiency Virus Type 1 in the Past Decade by GIRI, Malavika, UGEN, Kenneth E, WEINER, David B

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Identification of Novel Neutralizing Monoclonal Antibodies against SARS-CoV‑2 Spike Glycoprotein by Bordoloi, Devivasha, Xu, Ziyang, Ho, Michelle, Purwar, Mansi, Bhojnagarwala, Pratik, Cassel, Joel, Giron, Leila B, Walker, Susanne, Kulkarni, Abhijeet J, Ruiz, Edgar Tello, Choi, Jihae, Zaidi, Faraz I, Wu, Yuanhan, Wang, Shaoying, Patel, Ami, Ramos, Stephanie, Smith, Trevor, Kulp, Daniel, Ugen, Kenneth E, Srinivasan, Alagarsamy, Abdel-Mohsen, Mohamed, Humeau, Laurent, Weiner, David B, Muthumani, Kar

“…Coronavirus disease 2019 (COVID-19) is caused by the newly emerged human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the…”
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DNA vaccines 2014 meeting: Highlights and overview by Ugen, Kenneth E, Weiner, David B

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