Search Results - "Ugedo, L"

Chronic L-DOPA administration increases the firing rate but does not reverse enhanced slow frequency oscillatory activity and synchronization in substantia nigra pars reticulata neurons from 6-hydroxydopamine-lesioned rats by Aristieta, A, Ruiz-Ortega, J.A, Miguelez, C, Morera-Herreras, T, Ugedo, L

“…Abstract The pathophysiology of Parkinson's disease (PD) and of L-DOPA-induced dyskinesia (LID) is associated with dysfunctional neuronal activity in several…”
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Acute L-DOPA administration reverses changes in firing pattern and low frequency oscillatory activity in the entopeduncular nucleus from long term L-DOPA treated 6-OHDA-lesioned rats by Aristieta, A., Ruiz-Ortega, J.A., Morera-Herreras, T., Miguelez, C., Ugedo, L.

“…The pathophysiology of Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID) is associated with aberrant neuronal activity and abnormal high levels of…”
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The acute and long‐term L‐DOPA effects are independent from changes in the activity of dorsal raphe serotonergic neurons in 6‐OHDA lesioned rats by Miguelez, C, Navailles, S, De Deurwaerdère, P, Ugedo, L

“…Background and Purpose L‐DOPA is still the most efficacious pharmacological treatment for Parkinson's disease. However, in the majority of patients receiving…”
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Nanodelivery of Cerebrolysin and Rearing in Enriched Environment Induce Neuroprotective Effects in a Preclinical Rat Model of Parkinson’s Disease by Requejo, C., Ruiz-Ortega, J. A., Cepeda, H., Sharma, A., Sharma, H. S., Ozkizilcik, A., Tian, R., Moessler, H., Ugedo, L., Lafuente, J. V.

“…Rearing in enriched environment (EE) improves the recuperation in animal models of Parkinson’s disease (PD). Administration of TiO 2 -nanowired cerebrolysin…”
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Buspirone requires the intact nigrostriatal pathway to reduce the activity of the subthalamic nucleus via 5-HT1A receptors by Sagarduy, A., Llorente, J., Miguelez, C., Morera-Herreras, T., Ruiz-Ortega, J.A., Ugedo, L.

“…The most effective treatment for Parkinson's disease (PD), l-DOPA, induces dyskinesia after prolonged use. We have previously shown that in 6-hydroxydopamine…”
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A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat by Szot, P, Miguelez, C, White, S.S, Franklin, A, Sikkema, C, Wilkinson, C.W, Ugedo, L, Raskind, M.A

“…Abstract Degeneration of the noradrenergic neurons in the locus coeruleus (LC) is a major component of Alzheimer's (AD) and Parkinson's disease (PD), but the…”
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Deleterious Effects of VEGFR2 and RET Inhibition in a Preclinical Model of Parkinson’s Disease by Requejo, C., Ruiz-Ortega, J. A., Bengoetxea, H., Bulnes, S., Ugedo, L., Lafuente, J. V.

“…Neurotrophic factors (NTFs) are a promising therapeutic option for Parkinson’s disease (PD). They exert their function through tyrosine kinase receptors. Our…”
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Topographical Distribution of Morphological Changes in a Partial Model of Parkinson’s Disease—Effects of Nanoencapsulated Neurotrophic Factors Administration by Requejo, C., Ruiz-Ortega, J. A., Bengoetxea, H., Garcia-Blanco, A., Herrán, E., Aristieta, A., Igartua, M., Ugedo, L., Pedraz, J. L., Hernández, R. M., Lafuente, J. V.

“…Administration of various neurotrophic factors is a promising strategy against Parkinson’s disease (PD). An intrastriatal infusion of 6-hydroxidopamine…”
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The role of NMDA receptor‐dependent activity of noradrenergic neurons in attention, impulsivity and exploratory behaviors by Cieślak, P. E., Llamosas, N., Kos, T., Ugedo, L., Jastrzębska, K., Torrecilla, M., Rodriguez Parkitna, J.

“…Activity of the brain's noradrenergic (NA) neurons plays a major role in cognitive processes, including the ability to adapt behavior to changing environmental…”
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l-DOPA modifies the antidepressant-like effects of reboxetine and fluoxetine in rats by Miguelez, C., Berrocoso, E., Mico, J.A., Ugedo, L.

“…Nowadays the most widely used antidepressants are selective serotonin reuptake inhibitors (SSRI) or noradrenaline reuptake inhibitors (NRI), however, these…”
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Correction to: Deleterious Effects of VEGFR2 and RET Inhibition in a Preclinical Model of Parkinson’s Disease by Requejo, C., Ruiz-Ortega, J. A., Bengoetxea, H., Bulnes, S., Ugedo, L., Lafuente, J. V.

“…The authors found a terrible mistake in the manuscript. The legends from the Fig. 5 and 6 are interchanged. The Fig. 5 should be appeared with the legend from…”
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P.1.g.066 Altered presynaptic and postsynaptic transmission in dorsal raphe neurons of GIRK2 knockout mice by Llamosas, N, Ugedo, L, Torrecilla, M

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P.2.a.018 Dysfunctional inhibitory mechanisms in locus coeruleus neurons of the Wistar Kyoto rat by Bruzos-Cidon, C, Ugedo, L, Torrecilla, M

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Dysfunctional Inhibitory Mechanisms in Locus Coeruleus Neurons of the Wistar Kyoto Rat by Bruzos-Cidón, C, Llamosas, N, Ugedo, L, Torrecilla, M

“…Background: The noradrenergic nucleus locus coeruleus (LC) has functional relevance in several psychopathologies such as stress, anxiety, and depression. In…”
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Morphological Changes in a Severe Model of Parkinson’s Disease and Its Suitability to Test the Therapeutic Effects of Microencapsulated Neurotrophic Factors by Requejo, C., Ruiz-Ortega, J. A., Bengoetxea, H., García-Blanco, A., Herrán, E., Aristieta, A., Igartua, M., Pedraz, J. L., Ugedo, L., Hernández, R. M., Lafuente, J. V.

“…The unilateral 6-hydroxydopamine (6-OHDA) lesion of medial forebrain bundle (MFB) in rats affords us to study the advanced stages of Parkinson’s disease (PD)…”
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Modulation of the subthalamic nucleus activity by serotonergic agents and fluoxetine administration by Aristieta, A., Morera-Herreras, T., Ruiz-Ortega, J. A., Miguelez, C., Vidaurrazaga, I., Arrue, A., Zumarraga, M., Ugedo, L.

“…Rationale Within the basal ganglia, the subthalamic nucleus (STN) is the only glutamatergic structure and occupies a central position in the indirect pathway…”
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Altered neuronal activity and differential sensitivity to acute antidepressants of locus coeruleus and dorsal raphe nucleus in Wistar Kyoto rats: A comparative study with Sprague Dawley and Wistar rats by Bruzos-Cidón, C, Miguelez, C, Rodríguez, J.J, Gutiérrez-Lanza, R, Ugedo, L, Torrecilla, M

“…Abstract The Wistar Kyoto rat (WKY) has been proposed as an animal model of depression. The noradrenergic nucleus, locus coeruleus (LC) and the serotonergic…”
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ID 150 – STN neuron activity in patients carrying the R1441G mutation in the leucine-rich repeat kinase-2 (LRRK2) gene by Ruiz-Ortega, J.A, Lambarri, I, Bilbao, G, Miguelez, C, Morera-Herreras, T, de Gopegui, E. Ruiz, Tijero, B, Rodríguez, O, Villoria, R, Lezcano, E, Ugedo, L

“…Objective Mutations in the LRRK2 gene account for higher risk of suffering Parkinson’s disease (PD). To understand the basis of these differences we…”
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P.1.g.011 Effect of chronic fluoxetine treatment on subthalamic nucleus and catalepsy in the rat by Ugedo, L, Morera-Herreras, T, Ruiz-Ortega, J.A, Vidaurrazaga, I, Miguelez, C, Aristieta, A

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alpha(2)-Adrenoceptors mediate the acute inhibitory effect of fluoxetine on locus coeruleus noradrenergic neurons by Miguelez, C, Fernandez-Aedo, I, Torrecilla, M, Grandoso, L, Ugedo, L

“…So far, the mechanisms underlying the action of selective serotonin reuptake inhibitors, such as fluoxetine, are not completely understood. Thus, to clarify if…”
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