Search Results - "Ueyama, Azumi"

The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer by Haruna, Miya, Ueyama, Azumi, Yamamoto, Yoko, Hirata, Michinari, Goto, Kumiko, Yoshida, Hiroshi, Higuchi, Naoko, Yoshida, Tetsuya, Kidani, Yujiro, Nakamura, Yamami, Nagira, Morio, Kawashima, Atsunari, Iwahori, Kota, Shintani, Yasushi, Ohkura, Naganari, Wada, Hisashi

“…Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in…”
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Anti-CTLA-4 treatment suppresses hepatocellular carcinoma growth through Th1-mediated cell cycle arrest and apoptosis by Morihara, Hitomi, Yamada, Tomomi, Tona, Yumi, Akasaka, Marina, Okuyama, Hirohisa, Chatani, Natsumi, Shinonome, Satomi, Ueyama, Azumi, Kuwabara, Kenji, Fujio, Yasushi

“…Inhibiting the cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)-mediated immune checkpoint system using an anti-CTLA-4 antibody (Ab) can suppress the…”
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Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis by Oku, Hisashi, Shimizu, Toshikatsu, Kawabata, Tomoji, Nagira, Morio, Hikita, Ichiro, Ueyama, Azumi, Matsushima, Shuuichi, Torii, Mikinori, Arimura, Akinori

“…Pirfenidone, a broad-spectrum antifibrotic agent, is known to have efficacy in certain fibrotic disease models, and is under clinical trials in patients with…”
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Mechanism of pathogenesis of imiquimod-induced skin inflammation in the mouse: A role for interferon-alpha in dendritic cell activation by imiquimod by Ueyama, Azumi, Yamamoto, Mina, Tsujii, Kenichiro, Furue, Yoko, Imura, Chihiro, Shichijo, Michitaka, Yasui, Kiyoshi

“…Topical application of imiquimod (IMQ), a Toll‐like receptor (TLR)7 ligand, can induce and exacerbate psoriasis, a chronic inflammatory skin disorder. In a…”
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In situ analysis of CCR8 + regulatory T cells in lung cancer: suppression of GzmB + CD8 + T cells and prognostic marker implications by Hayashi, Yoshinori, Ueyama, Azumi, Funaki, Soichiro, Jinushi, Koichi, Higuchi, Naoko, Morihara, Hitomi, Hirata, Michinari, Nagira, Yoji, Saito, Takuro, Kawashima, Atsunari, Iwahori, Kota, Shintani, Yasushi, Wada, Hisashi

“…CCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This…”
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A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations by Imura, Chihiro, Ueyama, Azumi, Sasaki, Yoshikazu, Shimizu, Masaya, Furue, Yoko, Tai, Nobuyuki, Tsujii, Kenichiro, Katayama, Kazufumi, Okuno, Takayuki, Shichijo, Michitaka, Yasui, Kiyoshi, Yamamoto, Mina

“…•We evaluated the anti-psoriatic potential of our novel RORγt inhibitor, S18-000003.•Topical S18-000003 showed strong efficacy in a mouse model of…”
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Tetracyclines enhance antitumor T-cell immunity via the Zap70 signaling pathway by Tone, Mari, Iwahori, Kota, Hirata, Michinari, Ueyama, Azumi, Tani, Akiyoshi, Haruta, Jun-Ichi, Takeda, Yoshito, Shintani, Yasushi, Kumanogoh, Atsushi, Wada, Hisashi

“…BackgroundCancer immunotherapy including immune checkpoint inhibitors is only effective for a limited population of patients with cancer. Therefore, the…”
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Potential role of IL-17-producing CD4/CD8 double negative αβ T cells in psoriatic skin inflammation in a TPA-induced STAT3C transgenic mouse model by Ueyama, Azumi, Imura, Chihiro, Fusamae, Yasuyuki, Tsujii, Kenichiro, Furue, Yoko, Aoki, Miwa, Suzuki, Minoru, Okuda, Tomohiko, Oshima, Itsuki, Yasui, Kiyoshi, Shichijo, Michitaka, Yamamoto, Mina

“…Highlights • We examined cell populations involved in skin inflammation in K15.Stat3C mice. • Heterogeneous cell subsets produced IL-17 in TPA-treated…”
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Immunotherapy Targeting CCR8+ Regulatory T Cells Induces Antitumor Effects via Dramatic Changes to the Intratumor CD8+ T Cell Profile by Ueyama, Azumi, Nogami, Wataru, Nashiki, Kunitaka, Haruna, Miya, Miwa, Hiroto, Hagiwara, Masaki, Nagira, Morio, Wada, Hisashi, Nagira, Yoji

“…Regulatory T cells (Tregs) contribute to the formation of a tumor-immunosuppressive microenvironment. CCR8 is reportedly selectively expressed in tumor Tregs,…”
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CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory by Kidani, Yujiro, Nogami, Wataru, Yasumizu, Yoshiaki, Kawashima, Atsunari, Tanaka, Atsushi, Sonoda, Yudai, Tona, Yumi, Nashiki, Kunitaka, Matsumoto, Reimi, Hagiwara, Masaki, Osaki, Motonao, Dohi, Keiji, Kanazawa, Takayuki, Ueyama, Azumi, Yoshikawa, Mai, Yoshida, Tetsuya, Matsumoto, Mitsunobu, Hojo, Kanji, Shinonome, Satomi, Yoshida, Hiroshi, Hirata, Michinari, Haruna, Miya, Nakamura, Yamami, Motooka, Daisuke, Okuzaki, Daisuke, Sugiyama, Yasuko, Kinoshita, Makoto, Okuno, Tatsusada, Kato, Taigo, Hatano, Koji, Uemura, Motohide, Imamura, Ryoichi, Yokoi, Kazunori, Tanemura, Atsushi, Shintani, Yasushi, Kimura, Tadashi, Nonomura, Norio, Wada, Hisashi, Mori, Masaki, Doki, Yuichiro, Ohkura, Naganari, Sakaguchi, Shimon

“…Foxp3-expressing CD25 CD4 regulatory T cells (Tregs) are abundant in tumor tissues. Here, hypothesizing that tumor Tregs would clonally expand after they are…”
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The tissue-resident marker CD103 on peripheral blood T cells predicts responses to anti-PD-1 therapy in gastric cancer by Nose, Yohei, Saito, Takuro, Yamamoto, Kei, Yamashita, Kotaro, Tanaka, Koji, Yamamoto, Kazuyoshi, Makino, Tomoki, Takahashi, Tsuyoshi, Kawashima, Atsunari, Haruna, Miya, Hirata, Michinari, Ueyama, Azumi, Iwahori, Kota, Satoh, Taroh, Kurokawa, Yukinori, Eguchi, Hidetoshi, Doki, Yuichiro, Wada, Hisashi

“…Background Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. Since clinical benefits are limited to a subset of patients, we aimed to…”
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S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells by Nagira, Yoji, Nagira, Morio, Nagai, Ryohei, Nogami, Wataru, Hirata, Michinari, Ueyama, Azumi, Yoshida, Tetsuya, Yoshikawa, Mai, Shinonome, Satomi, Yoshida, Hiroshi, Haruna, Miya, Miwa, Hiroto, Chatani, Natsumi, Ohkura, Naganari, Wada, Hisashi, Tanaka, Hidekazu

“…Abstract Although regulatory T cells (Treg) are inhibitory immune cells that are essential for maintaining immune homeostasis, Tregs that infiltrate tumor…”
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Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003 by Sasaki, Yoshikazu, Odan, Masahide, Yamamoto, Shiho, Kida, Shiro, Ueyama, Azumi, Shimizu, Masaya, Haruna, Takayo, Watanabe, Ayahisa, Okuno, Takayuki

“…[Display omitted] •Highly potent RORγt inhibitors discovered by a precise SAR study.•Detailed binding mode discussion of the compound guided by X-ray cocrystal…”
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Tumor-infiltrating ICOS + Effector Regulatory T-Cells in Oral Squamous Cell Carcinoma as a Promising Biomarker for Prognosis and 'Hot' Tumor by Kajikawa, Hitomi, Hirata, Michinari, Haruna, Miya, Ueyama, Azumi, Hirose, Katsutoshi, Kawashima, Atsunari, Iwahori, Kota, Matsunaga, Kazuhide, Toyosawa, Satoru, Uzawa, Narikazu, Wada, Hisashi

“…Tumor immunity in the tumor microenvironment is activated in patients with feasible clinical responses to immune checkpoint inhibitors. The immunological…”
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S-531011, a novel anti-human CCR8 antibody, induces potent anti-tumor responses through depletion of tumor-infiltrating CCR8-expressing regulatory T cells by Nagira, Yoji, Nagira, Morio, Nagai, Ryohei, Nogami, Wataru, Hirata, Michinari, Ueyama, Azumi, Yoshida, Tetsuya, Yoshikawa, Mai, Shinonome, Satomi, Yoshida, Hiroshi, Haruna, Miya, Miwa, Hiroto, Chatani, Natsumi, Ohkura, Naganari, Wada, Hisashi, Tanaka, Hidekazu

“…While regulatory T cells (Tregs) are inhibitory immune cells that are essential for maintaining immune homeostasis, Tregs that infiltrate tumor tissue promote…”
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Neural-net-based cell deconvolution from DNA methylation reveals tumor microenvironment associated with cancer prognosis by Yasumizu, Yoshiaki, Hagiwara, Masaki, Umezu, Yuto, Fuji, Hiroaki, Iwaisako, Keiko, Asagiri, Masataka, Uemoto, Shinji, Nakamura, Yamami, Thul, Sophia, Ueyama, Azumi, Yokoi, Kazunori, Tanemura, Atsushi, Nose, Yohei, Saito, Takuro, Wada, Hisashi, Kakuda, Mamoru, Kohara, Masaharu, Nojima, Satoshi, Morii, Eiichi, Doki, Yuichiro, Sakaguchi, Shimon, Ohkura, Naganari

“…DNA methylation is a pivotal epigenetic modification that defines cellular identity. While cell deconvolution utilizing this information is considered useful…”
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