Microcrystalline cellulose from soybean husk: effects of solvent treatments on its properties as acetylsalicylic acid carrier

Microcrystalline cellulose from soybean husk: effects of solvent treatments on its properties as acetylsalicylic acid carrier

Microcrystalline cellulose (MCC) is a very important product in pharmaceutic, food, cosmetic and other industries. In this work, MCC was prepared from soybean husk, produced in large quantities in soybean oil processing industries. It was characterized through various techniques (scanning electron m...

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Bibliographic Details
Published in:International journal of pharmaceutics Vol. 206; no. 1; pp. 85 - 96
Main Authors: Uesu, Nelson Yoshio, Pineda, Edgardo Alfonso Gómez, Hechenleitner, Ana Adelina Winkler
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 25-09-2000
Elsevier
Subjects:
Acetylsalicylic acid
Analgesics
Analysis
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Aspirin - pharmacokinetics
Biological and medical sciences
Cellulose - chemistry
Cellulose - pharmacokinetics
Drug Carriers
Excipients - chemistry
Excipients - pharmacokinetics
General pharmacology
Glycine max - chemistry
Medical sciences
Microcrystalline cellulose
Neuropharmacology
Pharmacology. Drug treatments
Solvents - chemistry
Soybean husk
Thermal analysis
Thermal analysis
Acetylsalicylic acid
Microcrystalline cellulose
Soybean husk
Solvent effect
Pharmaceutical technology
Cellulose
Thermogravimetry
Drug carrier
Soybean
In vitro
Infrared spectrometry
Organic solvent
Chemical modification
Analgesic
Active ingredient
Tablet
Salicylates
Release
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Summary:Microcrystalline cellulose (MCC) is a very important product in pharmaceutic, food, cosmetic and other industries. In this work, MCC was prepared from soybean husk, produced in large quantities in soybean oil processing industries. It was characterized through various techniques (scanning electron microscopy (SEM), infrared spectroscopy (FTIR), thermogravimetry analysis (TGA) and differential scanning calorimetry (DSC)) and compared with a commercial MCC. The results obtained show that the prepared sample has similar crystallinity and lower particle size than the commercial MCC. Both MCC samples were treated with organic solvents (chloroform, acetone, ethanol and ethyl ether), for structural modifications to be introduced, and used as acetylsalicylic acid (ASA) carrier. Pretreated MCC and MCC/ASA 1:1 mixtures were analyzed through FTIR and thermal analysis. The drug release was evaluated in buffer solution of pH 4.5 and in pure water, at 37°C. The MCC pretreated with different solvents show different thermal properties and ASA release rates, each MCC showing a particular behavior.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(00)00532-9