Search Results - "Ueng, Y F"

The recommended dose of ertapenem poses a potential risk for central nervous system toxicity in haemodialysis patients – case reports and literature reviews by Lee, K.‐H., Ueng, Y.‐F., Wu, C.‐W., Chou, Y.‐C., Ng, Y.‐Y., Yang, W.‐C.

“…Summary What is known and objective Dosage adjustment of 500 mg ertapenem daily is recommended for patients with advanced kidney disease. 30% of ertapenem is…”
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Identification of Human Liver Cytochrome P-450 3A4 as the Enzyme Responsible for Fentanyl and Sufentanil N-Dealkylation by Tateishi, T., Krivoruk, Y., Ueng, Y-F., Wood, A. J. J., Guengerich, F. P., Wood, M.

“…Alfentanil, sufentanil, and fentanyl are synthetic opioids that are metabolized by oxidative N-dealkylation in the liver. We have previously shown that…”
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Homology modelling of human CYP1A2 based on the CYP2C5 crystallographic template structure by Lewis, D. F. V., Lake, B. G., Dickins, M., Ueng, Y.-F., Goldfarb, P. S.

“…1. The results of homology modelling of human cytochrome P4501A2 (CYP1A2) based on the CYP2C5 crystal structure are reported. It exhibits improved sequence…”
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Differential effects of carboxyfullerene on MPP +/MPTP-induced neurotoxicity by Lin, Anya M.Y, Yang, C.H, Ueng, Y.-F, Luh, T.Y, Liu, T.Y, Lay, Y.P, Ho, L.T

“…The effects of carboxyfullerene on a well-known neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its active metabolite…”
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Cooperativity in Oxidations Catalyzed by Cytochrome P450 3A4 by Ueng, Yune-Fang, Kuwabara, Takashi, Chun, Young-Jin, Guengerich, F. Peter

“…Cytochrome P450 (P450) 3A4 is the most abundant human P450 and oxidizes a diversity of substrates, including various drugs, steroids, carcinogens, and…”
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Enhancements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism and carcinogenic risk via NNK/arsenic interaction by Lee, Hui-Ling, Chang, Louis W., Wu, Jui-Pin, Ueng, Yune-Fang, Tsai, Ming-Hsien, Hsieh, Dennis Paul Hsientang, Lin, Pinpin

“…Epidemiological studies indicated an enhancement of cigarette smoke-induced carcinogenicity, including hepatocellular carcinoma, by arsenic. We believe that…”
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Effects of cadmium and environmental pollution on metallothionein and cytochrome P450 in tilapia by Ueng, Y F, Liu, C, Lai, C F, Meng, L M, Hung, Y Y, Ueng, T H

“…Tilapia given intraperitoneal doses of 0.2 to 10 mg cadmium chloride per kg had metallothionein (MT) activity in the liver measured after 24 h. Maximal MT…”
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Induction of cytochrome P450 1A1 and monooxygenase activity in Tilapia by sediment extract by UENG, Y.-F, LIU, T.-Y, UENG, T.-H

“…Cytochrome P450 (P450)-dependent monooxygenases of fishes are inducible by a variety of environmental pollutants including polycyclic aromatic hydrocarbons…”
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Identification of the Main Human Cytochrome P450 Enzymes Involved in Safrole 1‘-Hydroxylation by Ueng, Yune-Fang, Hsieh, Chih-Hang, Don, Ming-Jaw, Chi, Chin-Wen, Ho, Li-Kang

“…Safrole is a natural plant constituent, found in sassafras oil and certain other essential oils. The carcinogenicity of safrole is mediated through…”
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Inhibition of human cytochrome P450 enzymes by the natural hepatotoxin safrole by Ueng, Yune-Fang, Hsieh, Chih-Hang, Don, Ming-Jaw

“…The hepatotoxin, safrole is a methylenedioxy phenyl compound, found in sassafras oil and certain other essential oils. Recombinant cytochrome P450 (CYP, P450)…”
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Oxidation of Benzo[a]pyrene by Recombinant Human Cytochrome P450 Enzymes by Bauer, Eckhart, Guo, Zuyu, Ueng, Yune-Fang, Bell, L. Chastine, Zeldin, Darryl, Guengerich, F. Peter

“…The oxidation of benzo[a]pyrene (B[a]P) was examined using reconstituted systems prepared with recombinant human cytochrome P450 (P450) enzymes 1A1, 1A2, 2C8,…”
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Roles of Divalent Metal Ions in Oxidations Catalyzed by Recombinant Cytochrome P450 3A4 and Replacement of NADPH-Cytochrome P450 Reductase with Other Flavoproteins, Ferredoxin, and Oxygen Surrogates by Yamazaki, Hiroshi, Ueng, Yune-Fang, Shimada, Tsutomu, Guengerich, F. Peter

“…Recombinant cytochrome P450 (P450) 3A4 was most active in nifedipine and testosterone oxidation in a system including NADPH-P450 reductase, cytochrome b5 (b5),…”
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Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome P4501A2 by Ueng, Yune-Fang, Kuo, Ya-Hui, Peng, Hsiao-Chi, Chen, Ta-Liang, Jan, Woan-Ching, Guengerich, F. Peter, Lin, Yun-Lian

“…1. Tanshinone IIA is the main active diterpene quinone in the herbal medicine Salvia miltiorrhiza. In untreated mouse liver microsomes, tanshinone IIA…”
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Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities by Gillam, E.M.J., Guo, Z.Y., Ueng, Y.F., Yamazaki, H., Cock, I., Reilly, P.E.B., Hooper, W.D., Guengerich, F.P.

“…Cytochrome P450 (P450) 3A5 is a human enzyme with 85% amino acid sequence identity to the more predominantly expressed P450 3A4 and has been reported to have…”
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Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa by Ueng, Yune-Fang, Wang, Jong-Jing, Lin, Lie-Chwen, Park, Sang Shin, Chen, Chieh-Fu

“…Rutaecarpine is one of the main alkaloids of an herbal remedy, Evodia rutaecarpa, which has been used for the treatment of gastrointestinal disorder and…”
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Conjugation of Highly Reactive Aflatoxin B 1 exo- 8,9-Epoxide Catalyzed by Rat and Human Glutathione Transferases:  Estimation of Kinetic Parameters by Johnson, William W., Ueng, Yune-Fang, Widersten, Mikael, Mannervik, Bengt, Hayes, John D., Sherratt, Philip J., Ketterer, Brian, Guengerich, F. Peter

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Effects of baicalein and wogonin on drug-metabolizing enzymes in C57BL/6J mice by Ueng, Yune-Fang, Shyu, Chi-Chuo, Lin, Yun-Lian, Park, Sang Shin, Liao, Jyh-Fei, Chen, Chieh-Fu

“…Effects of baicalein and wogonin, the major flavonoids of Scutellariae radix, on cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and glutathione…”
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In vitro and in vivo effects of naringin on cytochrome P450-dependent monooxygenase in mouse liver by Ueng, Yune-Fang, Chang, Yuh-Lih, Oda, Yoshimitsu, Park, Sang S., Liao, Jyh-Fei, Lin, Min-Fang, Chen, Chieh-Fu

“…In vitro and in vivo effects of naringin on microsomal monooxygenase were studied to evaluate the drug interaction of this flavonoid. In vitro addition of…”
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Expression of cytochrome P450 3A7 in Escherichia coli: effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase by Gillam, E M, Wunsch, R M, Ueng, Y F, Shimada, T, Reilly, P E, Kamataki, T, Guengerich, F P

“…Cytochrome P450 3A7 is the major P450 form present in fetal liver tissue and may be responsible for the detoxification of many drugs that reach the fetal…”
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High Rates of Substrate Hydroxylation by Human Cytochrome P450 3A4 in Reconstituted Membranous Vesicles: Influence of Membrane Charge by Ingelman-Sundberg, Magnus, Hagbjörk, Ann-Louise, Ueng, Yune-Fang, Yamazaki, Hiroshi, Guengerich, F.Peter

“…CYP3A4 represents the most important form of human cytochrome P450 active in drug metabolism. Reconstitution of this enzyme has in the past been a major…”
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