Search Results - "Uemura, Kengo"

Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro by Asada-Utsugi, Megumi, Uemura, Kengo, Ayaki, Takashi, T. Uemura, Maiko, Minamiyama, Sumio, Hikiami, Ryota, Morimura, Toshifumi, Shodai, Akemi, Ueki, Takatoshi, Takahashi, Ryosuke, Kinoshita, Ayae, Urushitani, Makoto

“…DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates with age, in which cytoskeletal proteins are polymerized to repair DSB in…”
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The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway by Imai, Yuzuru, Kobayashi, Yoshito, Inoshita, Tsuyoshi, Meng, Hongrui, Arano, Taku, Uemura, Kengo, Asano, Takeshi, Yoshimi, Kenji, Zhang, Chang-Liang, Matsumoto, Gen, Ohtsuka, Toshiyuki, Kageyama, Ryoichiro, Kiyonari, Hiroshi, Shioi, Go, Nukina, Nobuyuki, Hattori, Nobutaka, Takahashi, Ryosuke

“…Leucine-rich repeat kinase 2 (LRRK2) is a key molecule in the pathogenesis of familial and idiopathic Parkinson's disease (PD). We have identified two novel…”
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Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile from Alzheimer's disease by Jingami, Naoto, Asada-Utsugi, Megumi, Uemura, Kengo, Noto, Rio, Takahashi, Makio, Ozaki, Akihiko, Kihara, Takeshi, Kageyama, Takashi, Takahashi, Ryosuke, Shimohama, Shun, Kinoshita, Ayae

“…The diagnosis of idiopathic normal pressure hydrocephalus (iNPH) is sometimes complicated by concomitant Alzheimer's disease (AD) pathology. The purpose of the…”
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High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation by Maesako, Masato, Uemura, Maiko, Tashiro, Yoshitaka, Sasaki, Kazuki, Watanabe, Kiwamu, Noda, Yasuha, Ueda, Karin, Asada-Utsugi, Megumi, Kubota, Masakazu, Okawa, Katsuya, Ihara, Masafumi, Shimohama, Shun, Uemura, Kengo, Kinoshita, Ayae

“…Obesity and type 2 diabetes are risk factors of Alzheimer's disease (AD). We reported that a high fat diet (HFD) promotes amyloid precursor protein (APP)…”
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Lipocalin-type prostaglandin D synthase: a glymphopathy marker in idiopathic hydrocephalus by Nishida, Namiko, Nagata, Nanae, Shimoji, Keigo, Jingami, Naoto, Uemura, Kengo, Ozaki, Akihiko, Takahashi, Makio, Urade, Yoshihiro, Matsumoto, Sadayuki, Iwasaki, Koichi, Okumura, Ryosuke, Ishikawa, Masatsune, Toda, Hiroki

“…Idiopathic normal pressure hydrocephalus in elderly people is considered a form of glymphopathy caused by malfunction of the waste clearance pathway, called…”
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The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease by Watanabe, Kiwamu, Uemura, Kengo, Asada, Megumi, Maesako, Masato, Akiyama, Haruhiko, Shimohama, Shun, Takahashi, Ryosuke, Kinoshita, Ayae

“…Alzheimer's disease (AD) is characterized by senile plaques, extracellular deposits composed primarily of amyloid-beta (Aβ), and neurofibrillary tangles, which…”
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Fibronectin type III domain-containing protein 5 interacts with APP and decreases amyloid β production in Alzheimer's disease by Noda, Yasuha, Kuzuya, Akira, Tanigawa, Kyousuke, Araki, Mitsugu, Kawai, Ryoko, Ma, Biao, Sasakura, Yoko, Maesako, Masato, Tashiro, Yoshitaka, Miyamoto, Masakazu, Uemura, Kengo, Okuno, Yasushi, Kinoshita, Ayae

“…The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer's disease (AD) pathology. Thus, the approach toward Aβ metabolism is…”
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PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates by Matsui, Hideaki, Gavinio, Roberto, Asano, Takeshi, Uemura, Norihito, Ito, Hidefumi, Taniguchi, Yoshihito, Kobayashi, Yoshito, Maki, Takakuni, Shen, Jie, Takeda, Shunichi, Uemura, Kengo, Yamakado, Hodaka, Takahashi, Ryosuke

“…Parkinson's disease (PD) is a common neurodegenerative disorder characterized by selective dopaminergic cell loss in the substantia nigra, but its pathogenesis…”
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Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice by Maesako, Masato, Uemura, Kengo, Iwata, Ayana, Kubota, Masakazu, Watanabe, Kiwamu, Uemura, Maiko, Noda, Yasuha, Asada-Utsugi, Megumi, Kihara, Takeshi, Takahashi, Ryosuke, Shimohama, Shun, Kinoshita, Ayae

“…High fat diet (HFD) is prevalent in many modern societies and HFD-induced metabolic condition is a growing concern worldwide. It has been previously reported…”
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Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models by Takeuchi, Hiroki, Yanagida, Takashi, Inden, Masatoshi, Takata, Kazuyuki, Kitamura, Yoshihisa, Yamakawa, Kentaro, Sawada, Hideyuki, Izumi, Yasuhiko, Yamamoto, Noriyuki, Kihara, Takeshi, Uemura, Kengo, Inoue, Haruhisa, Taniguchi, Takashi, Akaike, Akinori, Takahashi, Ryosuke, Shimohama, Shun

“…Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by dopaminergic (DA) neuronal cell loss in the substantia…”
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Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio by Uemura, Kengo, Lill, Christina M, Li, Xuejing, Peters, Jessica A, Ivanov, Alexander, Fan, Zhanyun, DeStrooper, Bart, Bacskai, Brian J, Hyman, Bradley T, Berezovska, Oksana

“…Presenilin 1(PS1) is the catalytic subunit of gamma-secretase, the enzyme responsible for the Abeta C-terminal cleavage site, which results in the production…”
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The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells by Honda, Makoto, Minami, Itsunari, Tooi, Norie, Morone, Nobuhiro, Nishioka, Hisae, Uemura, Kengo, Kinoshita, Ayae, Heuser, John E., Nakatsuji, Norio, Aiba, Kazuhiro

“…Cellular disease models are useful tools for Alzheimer's disease (AD) research. Pluripotent stem cells, including human embryonic stem cells (hESCs) and…”
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α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion by Yamakado, Hodaka, Moriwaki, Yasuhiro, Yamasaki, Nobuyuki, Miyakawa, Tsuyoshi, Kurisu, Junko, Uemura, Kengo, Inoue, Haruhisa, Takahashi, Makio, Takahashi, Ryosuke

“…► We generated genome-based human α-synuclein BAC tg mice. ► Tg mice showed decreased anxiety-like behaviors and hyperlocomotion. ► Increased SERT expression…”
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The first Japanese case of leukodystrophy with ovarian failure arising from novel compound heterozygous AARS2 mutations by Hamatani, Mio, Jingami, Naoto, Tsurusaki, Yoshinori, Shimada, Shino, Shimojima, Keiko, Asada-Utsugi, Megumi, Yoshinaga, Kenji, Uemura, Norihito, Yamashita, Hirofumi, Uemura, Kengo, Takahashi, Ryosuke, Matsumoto, Naomichi, Yamamoto, Toshiyuki

“…Even now, only a portion of leukodystrophy patients are correctly diagnosed, though various causative genes have been identified. In the present report, we…”
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A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish by Matsui, Hideaki, Taniguchi, Yoshihito, Inoue, Haruhisa, Uemura, Kengo, Takeda, Shunichi, Takahashi, Ryosuke

“…Parkinson's disease (PD) is the second most common neurodegenerative disease associated with the degeneration of dopaminergic neurons in the substantia nigra…”
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Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions by Li, Xuejing, Uemura, Kengo, Hashimoto, Tadafumi, Nasser-Ghodsi, Navine, Arimon, Muriel, Lill, Christina M, Palazzolo, Isabella, Krainc, Dimitri, Hyman, Bradley T, Berezovska, Oksana

“…Abstract Deposition of amyloid β (Aβ) containing plaques in the brain is one of the neuropathological hallmarks of Alzheimer's disease (AD). It has been…”
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Characterization of sequential N-cadherin cleavage by ADAM10 and PS1 by Uemura, Kengo, Kihara, Takeshi, Kuzuya, Akira, Okawa, Katsuya, Nishimoto, Takaaki, Ninomiya, Haruaki, Sugimoto, Hachiro, Kinoshita, Ayae, Shimohama, Shun

“…N-cadherin is essential for excitatory synaptic contact in the hippocampus. At the sites of synaptic contact, it forms a complex with Presenilin 1(PS1) and…”
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Loss of PINK1 in medaka fish ( Oryzias latipes) causes late-onset decrease in spontaneous movement by Matsui, Hideaki, Taniguchi, Yoshihito, Inoue, Haruhisa, Kobayashi, Yoshito, Sakaki, Yoshiyuki, Toyoda, Atsushi, Uemura, Kengo, Kobayashi, Daisuke, Takeda, Shunichi, Takahashi, Ryosuke

“…Parkinson's disease is a neurodegenerative disease associated with the degeneration of dopaminergic neurons in the substantia nigra. The PTEN-induced kinase 1…”
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Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation by Uemura, Kengo, Farner, Katherine C, Nasser-Ghodsi, Navine, Jones, Phill, Berezovska, Oksana

“…Several familial Alzheimer disease (FAD) mutations within the transmembrane region of the amyloid precursor protein (APP) increase the Aβ42/40 ratio without…”
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Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction by Minakawa, Eiko N., Yamakado, Hodaka, Tanaka, Atsushi, Uemura, Kengo, Takeda, Shunichi, Takahashi, Ryosuke

“…•A novel model of Parkinson's disease was created using DT40, a chicken B cell line.•Targeted gene disruption of DJ-1 in DT40 was utilized to generate this…”
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