Search Results - "Ueda, Yoshibumi"

The Role of Phosphoinositides in Synapse Function by Ueda, Yoshibumi

“…Since the discovery of phosphatidylinositol-3-kinase, scientific interest in the biological functions of phosphoinositides has greatly increased. Currently,…”
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Sphingomyelin localization in the intestinal crypt surface by Ueda, Yoshibumi, Abe, Mitsuhiro, Ishiwata, Toshiyuki, Ozawa, Takeaki

“…Macroscopic lipid observation in the organs of living small animals has not been realized. Here, we visualized sphingomyelin (SM) in the intestines of living…”
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Induction of Signal Transduction by Using Non‐Channelrhodopsin‐Type Optogenetic Tools by Ueda, Yoshibumi, Sato, Moritoshi

“…Signal transductions are the basis for all cellular functions. Previous studies investigating signal transductions mainly relied on pharmacological inhibition,…”
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Combined use of preoperative lymphocyte counts and the post/preoperative lymphocyte count ratio as a prognostic marker of recurrence after curative resection of stage II colon cancer by Shinji, Seiichi, Ueda, Yoshibumi, Yamada, Takeshi, Koizumi, Michihiro, Yokoyama, Yasuyuki, Takahashi, Goro, Hotta, Masahiro, Iwai, Takuma, Hara, Keisuke, Takeda, Kohki, Okusa, Mikihiro, Kan, Hayato, Uchida, Eiji

“…Diagnostic markers for recurrence of colorectal cancer have not been established. The aim of the present study was to identify new diagnostic markers for…”
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Increased spine PIP3 is sequestered from dendritic shafts by Ueda, Yoshibumi, Sugimoto, Naotoshi, Ozawa, Takeaki

“…Abstract Phosphatidylinositol 3,4,5-trisphosphate (PIP3) is a lipid second messenger that is crucial for the synaptic plasticity underlying learning and memory…”
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Optogenetic decoding of Akt2-regulated metabolic signaling pathways in skeletal muscle cells using transomics analysis by Kawamura, Genki, Kokaji, Toshiya, Kawata, Kentaro, Sekine, Yuka, Suzuki, Yutaka, Soga, Tomoyoshi, Ueda, Yoshibumi, Endo, Mizuki, Kuroda, Shinya, Ozawa, Takeaki

“…Insulin regulates various cellular metabolic processes by activating specific isoforms of the Akt family of kinases. Here, we elucidated metabolic pathways…”
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Deficiency of sphingomyelin synthase 2 prolongs survival by the inhibition of lymphoma infiltration through ICAM‐1 reduction by Taniguchi, Makoto, Ueda, Yoshibumi, Matsushita, Michiko, Nagaya, Shingo, Hashizume, Chieko, Arai, Kenta, Kabayama, Kazuya, Fukase, Koichi, Watanabe, Ken, Wardhani, Lusi Oka, Hayashi, Kazuhiko, Okazaki, Toshiro

“…ABSTRACT The tumor microenvironment (TME) formation involving host cells and cancer cells through cell adhesion molecules (CAMs) is essential for the multiple…”
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Membrane Dynamics Induced by a Phosphatidylinositol 3,4,5-Trisphosphate Optogenetic Tool by UEDA, Yoshibumi, II, Tatsuhito, AONO, Yuki, SUGIMOTO, Naotoshi, SHINJI, Seiichi, YOSHIDA, Hiroshi, SATO, Moritoshi

“…Membrane dynamic structures such as filopodia, lamellipodia, and ruffles have important cellular functions in phagocytosis and cell motility, and in…”
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Protocol for screening cellular outputs activated by optogenetically controlled temporal PI3K signaling activation patterns by Ueda, Yoshibumi, Matsushita, Shohei, Suzuki, Mitsugu, Ozawa, Takeaki

“…PI3K signaling elicits distinct outputs in response to different patterns of extracellular stimulation. Here, we present a protocol for screening cellular…”
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Epidermal growth factor-nanoparticle conjugates change the activity from anti-apoptotic to pro-apoptotic at membrane rafts by Yamamoto, Shota, Iwamaru, Yoshifumi, Shimizu, Yoshihisa, Ueda, Yoshibumi, Sato, Moritoshi, Yamaguchi, Kazuo, Nakanishi, Jun

“…[Display omitted] The proliferation epidermal growth factor (EGF) is known to acquire contradictory apoptotic activities upon conjugation with gold…”
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Establishment and characterization of a novel neuroendocrine carcinoma cell line derived from a human ascending colon tumor by Shinji, Seiichi, Sasaki, Norihiko, Yamada, Takeshi, Koizumi, Michihiro, Ohta, Ryo, Matsuda, Akihisa, Yokoyama, Yasuyuki, Takahashi, Goro, Hotta, Masahiro, Hara, Keisuke, Takeda, Kohki, Ueda, Koji, Kuriyama, Sho, Ishiwata, Toshiyuki, Ueda, Yoshibumi, Murakami, Takashi, Kanazawa, Yoshikazu, Yoshida, Hiroshi

“…The incidence of rare neuroendocrine tumors (NET) is rapidly increasing. Neuroendocrine carcinoma (NEC) is a NET with poorly differentiated histological…”
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An Engineered Biliverdin-Compatible Cyanobacteriochrome Enables a Unique Ultrafast Reversible Photoswitching Pathway by Tachibana, Sean R., Tang, Longteng, Zhu, Liangdong, Takeda, Yuka, Fushimi, Keiji, Ueda, Yoshibumi, Nakajima, Takahiro, Kuwasaki, Yuto, Sato, Moritoshi, Narikawa, Rei, Fang, Chong

“…Cyanobacteriochromes (CBCRs) are promising optogenetic tools for their diverse absorption properties with a single compact cofactor-binding domain. We…”
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Protein Engineering of Dual-Cys Cyanobacteriochrome AM1_1186g2 for Biliverdin Incorporation and Far-Red/Blue Reversible Photoconversion by Kuwasaki, Yuto, Miyake, Keita, Fushimi, Keiji, Takeda, Yuka, Ueda, Yoshibumi, Nakajima, Takahiro, Ikeuchi, Masahiko, Sato, Moritoshi, Narikawa, Rei

“…Cyanobacteria have cyanobacteriochromes (CBCRs), which are photoreceptors that bind to a linear tetrapyrrole chromophore and sense UV-to-visible light. A…”
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Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis by Sato, Moritoshi, Ueda, Yoshibumi, Takagi, Tokio, Umezawa, Yoshio

“…Phosphatidylinositol-3,4,5-trisphosphate (PtdInsP(3)) regulates diverse cellular functions, including cell proliferation and apoptosis, and has roles in the…”
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Male sex and history of ischemic heart disease are major risk factors for anastomotic leakage after laparoscopic anterior resection in patients with rectal cancer by Shinji, Seiichi, Ueda, Yoshibumi, Yamada, Takeshi, Koizumi, Michihiro, Yokoyama, Yasuyuki, Takahashi, Goro, Hotta, Masahiro, Iwai, Takuma, Hara, Keisuke, Takeda, Kohki, Okusa, Mikihiro, Kan, Hayato, Uchida, Eiji, Yoshida, Hiroshi

“…Anastomotic leakage (AL) is the most serious and common complication of surgery for rectal cancer, and associated risk factors remain unknown despite…”
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A New Anorectal Melanoma Cell Line Derived from a Primary Human Rectal Tumor by Shinji, Seiichi, Shichi, Yuuki, Yamada, Takeshi, Takahashi, Goro, Ohta, Ryo, Sonoda, Hiromichi, Matsuda, Akihisa, Yonaga, Kazuhide, Iwai, Takuma, Takeda, Kohki, Ueda, Koji, Kuriyama, Sho, Miyasaka, Toshimitsu, Ueda, Yoshibumi, Sasaki, Norihiko, Takahashi, Kimimasa, Ohashi, Ryuji, Ishiwata, Toshiyuki, Arai, Tomio, Yoshida, Hiroshi

“…Background: Anorectal melanoma is a rare disease with a poor prognosis. Symptoms are often nonspecific, which complicates preoperative diagnosis. Here, we…”
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Assembly Domain-Based Optogenetic System for the Efficient Control of Cellular Signaling by Furuya, Akihiro, Kawano, Fuun, Nakajima, Takahiro, Ueda, Yoshibumi, Sato, Moritoshi

“…We previously developed the Magnet system, which consists of two distinct Vivid protein variants, one positively and one negatively charged, designated the…”
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Regulation of the transbilayer movement of diacylglycerol in the plasma membrane by Ueda, Yoshibumi, Ishitsuka, Reiko, Hullin-Matsuda, Françoise, Kobayashi, Toshihide

“…This mini-review presents recent advances in the regulation of the membrane transbilayer movement (or flip-flop) of diacylglycerol (DAG), a key intermediate in…”
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Sphingomyelin regulates the transbilayer movement of diacylglycerol in the plasma membrane of Madin‐Darby canine kidney cells by Ueda, Yoshibumi, Makino, Asami, Murase‐Tamada, Kotono, Sakai, Shota, Inaba, Takehiko, Hullin‐Matsuda, Françoise, Kobayashi, Toshihide

“…Diacylglycerol (DAG) is a key component in lipid metabolism and signaling. Previous model membrane studies using DAG analogs suggest their rapid membrane…”
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Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane by Takagishi, Teruhisa, Oda, Masataka, Kabura, Michiko, Kurosawa, Mie, Tominaga, Kaori, Urano, Shiori, Ueda, Yoshibumi, Kobayashi, Keiko, Kobayashi, Toshihide, Sakurai, Jun, Terao, Yutaka, Nagahama, Masahiro

“…Clostridium perfringens alpha-toxin elicits various immune responses such as the release of cytokines, chemokines, and superoxide via the GM1a/TrkA complex…”
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