Synthesis and anti-MRSA Activity of Novel Cephalosporin Derivatives

Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to exhibit potent anti-MRSA activity in vitro and in vivo. The optimum C-7 sidechains utilized were 2,5-dichlorophenylthioacetamido and 2,6-dichloropy...

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Bibliographic Details

Published in:	Tetrahedron Vol. 56; no. 31; pp. 5687 - 5698
Main Authors:	D'Andrea, Stan V., Bonner, Daniel, Bronson, Joanne J., Clark, Junius, Denbleyker, Ken, Fung-Tomc, Joan, Hoeft, Shelley E., Hudyma, Thomas W., Matiskella, John D., Miller, Raymond F., Misco, Peter F., Pucci, Michael, Sterzycki, Roman, Tsai, Yuan, Ueda, Yasutsuga, Wichtowski, John A., Singh, Janak, Kissick, Thomas P., North, Jeffery T., Pullockaran, Annie, Humora, Michael, Boyhan, Brenda, Vu, Truc, Fritz, Alan, Heikes, J., Fox, Rita, Godfrey, Jollie D., Perrone, Robert, Kaplan, Murray, Kronenthal, David, Mueller, Richard H.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 28-07-2000
Subjects:	2,5-dichlorophenylthioacetamido 2,6-dichloropyrid-4-ylthioacetamido anti-MRSA activity novel cephalosporins 2,6-dichloropyrid-4-ylthioacetamido 2,5-dichlorophenylthioacetamido anti-MRSA activity novel cephalosporins
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