Treatment of Full-thickness Skin Defect with Concomitant Grafting of 6-fold Extended Mesh Auto-skin and Allogeneic Cultured Dermal Substitute

Treatment of Full-thickness Skin Defect with Concomitant Grafting of 6-fold Extended Mesh Auto-skin and Allogeneic Cultured Dermal Substitute

:  The aim of this clinical study was to evaluate an allogeneic cultured dermal substitute (CDS) as a biological dressing for highly extended mesh auto‐skin grafting. The subjects were five patients with extensive deep burn wounds. Allogeneic CDS was prepared by seeding fibroblasts on a spongy matri...

Full description

Saved in:
Bibliographic Details
Published in:Artificial organs Vol. 28; no. 5; pp. 444 - 450
Main Authors: Kashiwa, Naohiro, Ito, Osamu, Ueda, Takeshige, Kubo, Kentaro, Matsui, Hiromichi, Kuroyanagi, Yoshimitsu
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Science Inc 01-05-2004
Subjects:
Adult
Aged
Aged, 80 and over
Burns - surgery
Collagen
Cultured dermal substitute
Dermatologic Surgical Procedures
Dermis - growth & development
Female
Fibroblasts
Humans
Hyaluronic acid
Male
Mesh skin grafting
Skin - metabolism
Skin Transplantation - methods
Skin, Artificial
Surgical Mesh
Tissue Engineering
Transplantation, Homologous
Treatment Outcome
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary::  The aim of this clinical study was to evaluate an allogeneic cultured dermal substitute (CDS) as a biological dressing for highly extended mesh auto‐skin grafting. The subjects were five patients with extensive deep burn wounds. Allogeneic CDS was prepared by seeding fibroblasts on a spongy matrix of hyaluronic acid and atelo‐collagen. Six‐fold extended auto‐skin graft was applied to the debrided wound, on which allogeneic CDS was placed. A conventional ointment‐gauze dressing was used to protect the CDS. The CDS was applied repeatedly at intervals of 5–7 days. In all cases, the wounds were closed by successful take of mesh auto‐skin graft and prompt epithelization from the grafted skin. The skin on the grafted area had a cicatrix appearance, but was soft and thin, maintaining good quality. The application of 6‐fold extended auto‐skin graft in conjunction with allogeneic CDS is an effective method for treatment of extensive severe  burn  wounds.
Bibliography:ark:/67375/WNG-BQQ37X9T-2
ArticleID:AOR0009
istex:A9427D909832EA4015769829C42D129453FF1AF9
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Report-3
ObjectType-Case Study-4
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2004.00009.x