Search Results - "Udyavar, Akshata"

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer by Desbois, Mélanie, Udyavar, Akshata R., Ryner, Lisa, Kozlowski, Cleopatra, Guan, Yinghui, Dürrbaum, Milena, Lu, Shan, Fortin, Jean-Philippe, Koeppen, Hartmut, Ziai, James, Chang, Ching-Wei, Keerthivasan, Shilpa, Plante, Marie, Bourgon, Richard, Bais, Carlos, Hegde, Priti, Daemen, Anneleen, Turley, Shannon, Wang, Yulei

“…Close proximity between cytotoxic T lymphocytes and tumour cells is required for effective immunotherapy. However, what controls the spatial distribution of T…”
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Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity by Udyavar, Akshata R, Wooten, David J, Hoeksema, Megan, Bansal, Mukesh, Califano, Andrea, Estrada, Lourdes, Schnell, Santiago, Irish, Jonathan M, Massion, Pierre P, Quaranta, Vito

“…Small cell lung cancer (SCLC) is a devastating disease due to its propensity for early invasion and refractory relapse after initial treatment response…”
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Transcriptomic profiling of adjuvant colorectal cancer identifies three key prognostic biological processes and a disease specific role for granzyme B by Daemen, Anneleen, Udyavar, Akshata R, Sandmann, Thomas, Li, Congfen, Bosch, Linda J W, O'Gorman, William, Li, Yijin, Au-Yeung, Amelia, Takahashi, Chikara, Kabbarah, Omar, Bourgon, Richard, Hegde, Priti, Bais, Carlos, Das Thakur, Meghna

“…Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with a 5% 5-year survival rate for metastatic disease, yet with limited therapeutic…”
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Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity by Piovesan, Dana, Tan, Joanne B L, Becker, Annette, Banuelos, Jesus, Narasappa, Nell, DiRenzo, Daniel, Zhang, Kristen, Chen, Ada, Ginn, Elaine, Udyavar, Akshata R, Yin, Fangfang, Paprcka, Susan L, Purandare, Bhamini, Park, Timothy W, Kimura, Nikki, Kalisiak, Jaroslaw, Young, Stephen W, Powers, Jay P, Schindler, Uli, Sivick, Kelsey E, Walters, Matthew J

“…T cells play a critical role in the control of cancer. The development of immune checkpoint blockers (ICB) aimed at enhancing antitumor T-cell responses has…”
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Intrinsic and acquired drug resistance to LSD1 inhibitors in small cell lung cancer occurs through a TEAD4‐driven transcriptional state by Yan, Wen, Chung, Chi‐Yeh, Xie, Tao, Ozeck, Mark, Nichols, Timothy C., Frey, Jessica, Udyavar, Akshata R., Sharma, Shikhar, Paul, Thomas A.

“…Small‐cell lung cancer (SCLC) is a heterogeneous disease, consisting of intratumoral and intertumoral neuroendocrine (ASCL1 and/or NEUROD1), mesenchymal‐like,…”
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Co-expression network analysis identifies Spleen Tyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancer by Udyavar, Akshata R, Hoeksema, Megan D, Clark, Jonathan E, Zou, Yong, Tang, Zuojian, Li, Zhiguo, Li, Ming, Chen, Heidi, Statnikov, Alexander, Shyr, Yu, Liebler, Daniel C, Field, John, Eisenberg, Rosana, Estrada, Lourdes, Massion, Pierre P, Quaranta, Vito

“…Oncogenic mechanisms in small-cell lung cancer remain poorly understood leaving this tumor with the worst prognosis among all lung cancers. Unlike other cancer…”
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Genomic Alterations Associated with Recurrence and TNBC Subtype in High-Risk Early Breast Cancers by Wilson, Timothy R, Udyavar, Akshata R, Chang, Ching-Wei, Spoerke, Jill M, Aimi, Junko, Savage, Heidi M, Daemen, Anneleen, O'Shaughnessy, Joyce A, Bourgon, Richard, Lackner, Mark R

“…The identification of early breast cancer patients who may benefit from adjuvant chemotherapy has evolved to include assessment of clinicopathologic features…”
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Correction: Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity by Udyavar, Akshata R, Wooten, David J, Hoeksema, Megan, Bansal, Mukesh, Califano, Andrea, Estrada, Lourdes, Schnell, Santiago, Irish, Jonathan M, Massion, Pierre P, Quaranta, Vito

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Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor reactivity of tumor infiltrating lymphocytes by Kalaitsidou, Milena, Moon, Owen R, Sykorova, Martina, Bao, Leyuan, Qu, Yun, Sukumaran, Sujita, Valentine, Michael, Zhou, Xingliang, Pandey, Veethika, Foos, Kay, Medvedev, Sergey, Powell, Jr, Daniel J, Udyavar, Akshata, Gschweng, Eric, Rodriguez, Ruben, Dudley, Mark E, Hawkins, Robert E, Kueberuwa, Gray, Bridgeman, John S

“…Transfer of autologous tumor infiltrating lymphocytes (TIL) to patients with refractory melanoma has shown clinical efficacy in a number of trials. However,…”
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Altered TGF‐α/β signaling drives cooperation between breast cancer cell populations by Franco, Omar E., Tyson, Darren R., Konvinse, Katherine C., Udyavar, Akshata R., Estrada, Lourdes, Quaranta, Vito, Crawford, Susan E., Hayward, Simon W.

“…ABSTRACT The role of tumor heterogeneity in regulating disease progression is poorly understood. We hypothesized that interactions between subpopulations of…”
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Subtle Affinity-Enhancing Mutations in a Myelin Oligodendrocyte Glycoprotein-Specific TCR Alter Specificity and Generate New Self-Reactivity by Udyavar, Akshata, Alli, Rajshekhar, Nguyen, Phuong, Baker, Lesley, Geiger, Terrence L

“…We describe a simple iterative approach to augment TCR affinity, which we studied using a myelin oligodendrocyte glycoprotein-specific TCR. We hypothesized…”
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509 Potent and selective inhibition Of AXL receptor tyrosine kinase for the treatment of cancer by Paprcka, Susan, Udyavar, Akshata, Sridhar, Subhasree, Miles, Dillon, Chen, Yu, Cho, Sean, Foley, Corinne, Grange, Rebecca, Leleti, Manmohan, Zhao, Sharon, Jin, Lixia, Young, Stephen, Powers, Jay, Walters, Matthew

“…BackgroundAXL receptor tyrosine kinase (AXL) is a transmembrane protein that is over-expressed in a variety of cancer and immune cells. AXL signaling has been…”
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338 Emerging insights on the association of tumor molecular phenotype with clinical benefit in metastatic colorectal cancer (mCRC) subjects treated with AB928 + modified FOLFOX-6 (mFOLFOX-6) by Udyavar, Akshata, Cecchini, Michael, DiRenzo, Daniel, Cho, Sean, Seitz, Lisa, Zhang, Kristen, Young, Stephen, Anderson, Amy, Gerrick, Kimberline, Walters, Matthew, Gilbert, Houston, Gardner, Olivia, Quah, Cheng, Jaen, Juan, Grossman, William

“…BackgroundThe release of ATP from dying cancer cells in response to platinum-based chemotherapy increases extracellular adenosine, which binds to and activates…”
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583 Novel, potent, and selective inhibitors of hypoxia-inducible factor (HIF)-2α reverse pro-tumorigenic transcriptional programming in cancer, stromal, and immune cells by Gauthier, Kelsey Sivick, Piovesan, Dana, Lawson, Kenneth, Cho, Soonweng, Udyavar, Akshata, Chan, Jean, Chen, Ada, Au, Jennie, Meleza, Cesar, Zhao, Xiaoning, Tran, Anh, Drew, Samuel, Gal, Balint, Rosen, Brandon, Leleti, Manmohan, Ginn, Elaine, Jin, Lixia, Young, Stephen, Powers, Jay, Walters, Matthew

“…BackgroundThe microenvironment of solid tumors is hypoxic and requires induction of genes associated with metabolism, growth, proliferation, and angiogenesis…”
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408 PK/PD biomarker analysis to assess tumor-specific enrichment and payload delivery of ACTM-838, a microbial-based immunotherapy by Cron, Kyle, Fang, Ping, Pham, Oanh, Janes, Julie, Brandenburg, John, Tribble, Sara, Miyashita-Lin, Emily, He, Hailey, Joshi, Omkar, Thanos, Christopher, Whiting, Chan, Udyavar, Akshata R

“…BackgroundACTM-838 is a bacterial immunotherapy that encodes an engineered IL-15 (IL-15plex) and a constitutively active STING (eSTING). ACTM-838 is a highly…”
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Abstract CT129: ARC-3: Updated results of etrumadenant (AB928) + modified FOLFOX-6 (mFOLFOX-6) in metastatic colorectal cancer (mCRC) patients by Cecchini, Michael, Quah, Cheng, Liu, Shiyao, Woloski, Rachel, Udyavar, Akshata, Giannakis, Marios

“…Abstract Background: The release of ATP from dying cancer cells in response to platinum-based chemotherapy increases immunosuppressive extracellular adenosine,…”
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ARC-8: Phase I/Ib study to evaluate safety and tolerability of AB680 + chemotherapy + zimberelimab (AB122) in patients with treatment-naive metastatic pancreatic adenocarcinoma (mPDAC) by Manji, Gulam Abbas, Wainberg, Zev A., Krishnan, Kartik, Giafis, Nick, Udyavar, Akshata, Quah, Cheng Seok, Scott, Jennifer, Berry, Wade, DiRenzo, Daniel, Gerrick, Kimberline, Jin, Lixia, Bendell, Johanna C.

“…Abstract only 404 Background: AB680, a potent, selective small-molecule inhibitor of soluble and membrane-bound CD73, targets a major pathway of extracellular…”
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Antitumor activity of T cells expressing a novel anti-folate receptor alpha (FOLR1) costimulatory antigen receptor (CoStAR) in a human xenograft murine solid tumor model and implications for in-human studies by Moon, Owen R., Qu, Yun, King, Michael G., Mojadidi, Michelle, Chauvin-Fleurence, Cynthia, Yarka, Clare, Evans, Alicia, Zhou, Xingliang, Katopodi, Tania (Theoni), Udyavar, Akshata, Bridgeman, John S., Kueberuwa, Gray, Alvarez-Rodríguez, Rubén

“…2535 Background: ITIL-306 is an autologous tumor-infiltrating lymphocyte (TIL) therapy that integrates T-cell receptor (TCR)-specific antigen recognition…”
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Abstract 4980: Altered pan-Ras pathway and activating mutations in EGFR result in elevated CD73 in multiple cancers by Udyavar, Akshata R., DiRenzo, Daniel, Ashok, Devika, Anderson, Amy E., Young, Stephen W., Walters, Matt J., Tan, Joanne Bl

“…Abstract Background: Adenosine production mediated by CD73 and/or TNAP is a potential mechanism of immune suppression across many cancer types. We have…”
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Abstract 736: ACTM-838 safely and comprehensively re-activates the immunosuppressive TME by exploiting myeloid biology intrinsic in many cancers by Lu, William, Cron, Kyle, Janes, Julie, Berryman, Leigh, Singh, Gurvinder, Thanos, Christopher, Udyavar, Akshata

“…Abstract ACTM-838 is a genetically modified bacterial vehicle encoding a DNA plasmid with two engineered payloads, IL-15plex and constitutively active eSTING…”
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