Search Results - "Udono, Miyako"

Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors by Takashima, Yasuo, Horisawa, Kenichi, Udono, Miyako, Ohkawa, Yasuyuki, Suzuki, Atsushi

“…Hepatocellular carcinoma (HCC) accounts for a large proportion of liver cancer cases and has an extremely poor prognosis. Therefore, novel innovative therapies…”
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Molecular Mechanisms for the Carnosine-Induced Activation of Muscle-Brain Interaction by Ishibashi, Asuka, Udono, Miyako, Sato, Mikako, Katakura, Yoshinori

“…Carnosine is known to improve brain function. The molecular basis for the carnosine-mediated interaction between intestinal cells and neuronal cells is that…”
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Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion by Ogawa, Mizuki, Udono, Miyako, Teruya, Kiichiro, Uehara, Norihisa, Katakura, Yoshinori

“…Enhanced telomerase reverse transcriptase (TERT) levels in dermal keratinocytes can serve as a novel target for hair growth promotion. Previously, we…”
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The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors by Horisawa, Kenichi, Udono, Miyako, Ueno, Kazuko, Ohkawa, Yasuyuki, Nagasaki, Masao, Sekiya, Sayaka, Suzuki, Atsushi

“…Specific combinations of two transcription factors (Hnf4α plus Foxa1, Foxa2, or Foxa3) can induce direct conversion of mouse fibroblasts into hepatocyte-like…”
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Exosome-Mediated Activation of Neuronal Cells Triggered by γ-Aminobutyric Acid (GABA) by Inotsuka, Ryo, Udono, Miyako, Yamatsu, Atsushi, Kim, Mujo, Katakura, Yoshinori

“…γ-Aminobutyric acid (GABA) is a potent bioactive amino acid, and several studies have shown that oral administration of GABA induces relaxation, improves…”
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Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells by Inada, Hiroki, Udono, Miyako, Matsuda-Ito, Kanae, Horisawa, Kenichi, Ohkawa, Yasuyuki, Miura, Shizuka, Goya, Takeshi, Yamamoto, Junpei, Nagasaki, Masao, Ueno, Kazuko, Saitou, Daisuke, Suyama, Mikita, Maehara, Yoshihiko, Kumamaru, Wataru, Ogawa, Yoshihiro, Sekiya, Sayaka, Suzuki, Atsushi

“…Recent advances have enabled the direct induction of human tissue-specific stem and progenitor cells from differentiated somatic cells. However, it is not…”
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Suppression of lethal‐7b and miR‐125a/b Maturation by Lin28b Enables Maintenance of Stem Cell Properties in Hepatoblasts by Takashima, Yasuo, Terada, Maiko, Udono, Miyako, Miura, Shizuka, Yamamoto, Junpei, Suzuki, Atsushi

“…In liver development, hepatoblasts that act as hepatic stem/progenitor cells proliferate and differentiate into both hepatocytes and cholangiocytes to form…”
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SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene by Yamashita, Shuntaro, Ogawa, Kaori, Ikei, Takahiro, Udono, Miyako, Fujiki, Tsukasa, Katakura, Yoshinori

“…► SIRT1 activated the transcription and activity of c-MYC in HUC-F2 cells. ► SIRT1 activated the transcription of hTERT through the involvement of c-MYC. ►…”
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Identification and Functional Evaluation of Polyphenols That Induce Regulatory T Cells by Fujiki, Tsukasa, Shinozaki, Ryosuke, Udono, Miyako, Katakura, Yoshinori

“…Regulatory T cells (Tregs) and CD4+/CD25+ T cells play an important role in the suppression of excessive immune responses, homeostasis of immune function, and…”
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Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling by Yamamoto, Junpei, Udono, Miyako, Miura, Shizuka, Sekiya, Sayaka, Suzuki, Atsushi

“…Recent progress in direct lineage reprogramming has enabled the generation of induced hepatocyte-like (iHep) cells and revealed their potential as an…”
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Direct Conversion of Human Endothelial Cells Into Liver Cancer‐Forming Cells Using Nonintegrative Episomal Vectors by Goya, Takeshi, Horisawa, Kenichi, Udono, Miyako, Ohkawa, Yasuyuki, Ogawa, Yoshihiro, Sekiya, Sayaka, Suzuki, Atsushi

“…Liver cancer is an aggressive cancer associated with a poor prognosis. Development of therapeutic strategies for liver cancer requires fundamental research…”
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Quantitative analysis of cellular senescence phenotypes using an imaging cytometer by Udono, Miyako, Kadooka, Keishi, Yamashita, Shuntaro, Katakura, Yoshinori

“…Until now, various stimuli as well as serial passaging have been known to induce cellular senescence in normal human diploid fibroblasts. However, in many…”
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Impaired ATP6V0A2 expression contributes to Golgi dispersion and glycosylation changes in senescent cells by Udono, Miyako, Fujii, Kaoru, Harada, Gakuro, Tsuzuki, Yumi, Kadooka, Keishi, Zhang, Pingbo, Fujii, Hiroshi, Amano, Maho, Nishimura, Shin-Ichiro, Tashiro, Kosuke, Kuhara, Satoru, Katakura, Yoshinori

“…Many genes and signaling pathways have been found to be involved in cellular senescence program. In the present study, we have identified 16…”
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Enhanced vulnerability to oxidative stress and induction of inflammatory gene expression in 3‐phosphoglycerate dehydrogenase‐deficient fibroblasts by Hamano, Momoko, Haraguchi, Yurina, Sayano, Tomoko, Zyao, Chong, Arimoto, Yashiho, Kawano, Yui, Moriyasu, Kazuki, Udono, Miyako, Katakura, Yoshinori, Ogawa, Takuya, Kato, Hisanori, Furuya, Shigeki

“…l‐Serine (l‐Ser) is a necessary precursor for the synthesis of proteins, lipids, glycine, cysteine, d‐serine, and tetrahydrofolate metabolites. Low l‐Ser…”
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Adaptive response to l‐serine deficiency is mediated by p38 MAPK activation via 1‐deoxysphinganine in normal fibroblasts by Sayano, Tomoko, Kawano, Yuki, Kusada, Wataru, Arimoto, Yashiho, Esaki, Kayoko, Hamano, Momoko, Udono, Miyako, Katakura, Yoshinori, Ogawa, Takuya, Kato, Hisanori, Hirabayashi, Yoshio, Furuya, Shigeki

“…Reduced availability of l‐serine limits cell proliferation and leads to an adaptation to l‐serine‐deficient environment, the underlying molecular mechanism of…”
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Effects of Kurozu concentrated liquid on adipocyte size in rats by Tong, Li-Tao, Katakura, Yoshinori, Kawamura, Sayaka, Baba, Sanae, Tanaka, Yasutake, Udono, Miyako, Kondo, Yoshie, Nakamura, Kumi, Imaizumi, Katsumi, Sato, Masao

“…Kurozu concentrated liquid (KCL) is used as a health-promoting supplement for the treatment of disorders such as cancer, hyperlipidemia, and hypertension in…”
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Protein Kinase C δ Plays a Key Role in Cellular Senescence Programs of Human Normal Diploid Cells by Katakura, Yoshinori, Udono, Miyako, Katsuki, Kazuyuki, Nishide, Hisaya, Tabira, Yukiko, Ikei, Takahiro, Yamashita, Makiko, Fujiki, Tsukasa, Shirahata, Sanetaka

“…In the present study, we clarified that transforming growth factor β (TGF-β) induces cellular senescence in human normal diploid cells, TIG-1, and identified…”
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Pro-senescent effect of hydrogen peroxide on cancer cells and its possible application to tumor suppression by Yoshizaki, K.(Kyushu Univ., Fukuoka (Japan). Faculty of Agriculture), Fujiki, T, Tsunematsu, T, Yamashita, M, Udono, M, Shirahata, S, Katakura, Y

“…Mild oxidative stress is known to induce premature senescence, termed stress-induced premature senescence (SIPS), in normal human diploid cells. We…”
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Construction of a Regulatable Cancer-Specific Adenoviral Expression System Using Human Telomerase Reverse Transcriptase Gene Promoter by UDONO, Miyako, FUJIKI, Tsukasa, YAMASHITA, Makiko, KATSUKI, Kazuyuki, FUNATA, Masaaki, IMADA, Yusuke, YOSHIZAKI, Kaichi, SHIRAHATA, Sanetaka, KATAKURA, Yoshinori

“…We constructed a novel cancer-specific regulatable adenoviral expression system comprising two vectors: one expressing rtTA, a reverse tetracycline…”
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Fructobacillus fructosus OS-1010 strain stimulates intestinal cells to secrete exosomes that activate muscle cells by Kashiwagi, Riku, Udono, Miyako, Katakura, Yoshinori

“…Fructobacillus is a lactic-acid bacterium recently identified in fructose-rich environments. Fructobacillus is also known to exhibit unusual growth…”
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