Search Results - "Udo S Gaipl"

The Immune System in Cancer Prevention, Development and Therapy by Candeias, Serge M, Gaipl, Udo S

“…The immune system plays a pivotal role in the maintenance of the integrity of an organism. Besides the protection against pathogens, it is strongly involved in…”
Get more information

Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis by Tajik, Narges, Frech, Michael, Schulz, Oscar, Schälter, Fabian, Lucas, Sébastien, Azizov, Vugar, Dürholz, Kerstin, Steffen, Franziska, Omata, Yasunori, Rings, Andreas, Bertog, Marko, Rizzo, Aroldo, Iljazovic, Aida, Basic, Marijana, Kleyer, Arnd, Culemann, Stephan, Krönke, Gerhard, Luo, Yubin, Überla, Klaus, Gaipl, Udo S., Frey, Benjamin, Strowig, Till, Sarter, Kerstin, Bischoff, Stephan C., Wirtz, Stefan, Cañete, Juan D., Ciccia, Francesco, Schett, Georg, Zaiss, Mario M.

“…Gut microbial dysbiosis is associated with the development of autoimmune disease, but the mechanisms by which microbial dysbiosis affects the transition from…”
Get full text

Immune biological rationales for the design of combined radio- and immunotherapies by Hader, Michael, Frey, Benjamin, Fietkau, Rainer, Hecht, Markus, Gaipl, Udo S.

“…Cancer immunotherapies are promising treatments for many forms of cancer. Nevertheless, the response rates to, e.g., immune checkpoint inhibitors (ICI), are…”
Get full text

Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies by Rückert, Michael, Deloch, Lisa, Fietkau, Rainer, Frey, Benjamin, Hecht, Markus, Gaipl, Udo S.

“…Background Radiotherapy (RT) has been known for decades as a local treatment modality for malign and benign disease. In order to efficiently exploit the…”
Get full text

The Influence of Radiation on Bone and Bone Cells-Differential Effects on Osteoclasts and Osteoblasts by Donaubauer, Anna-Jasmina, Deloch, Lisa, Becker, Ina, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S

“…The bone is a complex organ that is dependent on a tight regulation between bone formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCs). These…”
Get full text

Chemoradiation Increases PD-L1 Expression in Certain Melanoma and Glioblastoma Cells by Derer, Anja, Spiljar, Martina, Bäumler, Monika, Hecht, Markus, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S

“…Immunotherapy approaches currently make their way into the clinics to improve the outcome of standard radiochemotherapy (RCT). The programed cell death…”
Get full text

Editorial: Systemic immune dysregulation in malignant disease: Insights, monitoring and therapeutic exploitation by Christopoulos, Petros, Gaipl, Udo S

Get full text

Editorial to Radiation in Multimodal Tumor Immune Therapies—Mechanisms and Application by Frey, Benjamin, Gaipl, Udo S.

“…The understanding and the application of radiation-induced immune modulation has become more and more relevant in the therapy of malignant, but also benign…”
Get full text

Radon Exposure-Therapeutic Effect and Cancer Risk by Maier, Andreas, Wiedemann, Julia, Rapp, Felicitas, Papenfuß, Franziska, Rödel, Franz, Hehlgans, Stephanie, Gaipl, Udo S, Kraft, Gerhard, Fournier, Claudia, Frey, Benjamin

“…Largely unnoticed, all life on earth is constantly exposed to low levels of ionizing radiation. Radon, an imperceptible natural occurring radioactive noble…”
Get full text

Clinically Relevant Radiation Exposure Differentially Impacts Forms of Cell Death in Human Cells of the Innate and Adaptive Immune System by Falcke, Sylvia E, Rühle, Paul F, Deloch, Lisa, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S

“…In cancer treatments, especially high-dose radiotherapy (HDRT) is applied. Patients suffering from chronic inflammatory diseases benefit from low-dose…”
Get full text

Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses by Datta, Niloy R., Kok, H. Petra, Crezee, Hans, Gaipl, Udo S., Bodis, Stephan

“…Moderate hyperthermia at temperatures between 40 and 44°C is a multifaceted therapeutic modality. It is a potent radiosensitizer, interacts favorably with a…”
Get full text

Gas plasma irradiation of breast cancers promotes immunogenicity, tumor reduction, and an abscopal effect in vivo by Mahdikia, Hamed, Saadati, Fariba, Freund, Eric, Gaipl, Udo S., Majidzadeh-a, Keivan, Shokri, Babak, Bekeschus, Sander

“…While many new and emerging therapeutic concepts have appeared throughout the last decades, cancer still is fatal in many patients. At the same time, the…”
Get full text

Development of a Modular Assay for Detailed Immunophenotyping of Peripheral Human Whole Blood Samples by Multicolor Flow Cytometry by Rühle, Paul F, Fietkau, Rainer, Gaipl, Udo S, Frey, Benjamin

“…The monitoring of immune cells gained great significance in prognosis and prediction of therapy responses. For analyzing blood samples, the multicolor flow…”
Get full text

Anti-inflammatory effects of an autologous gold-based serum therapy in osteoarthritis patients by Feldt, Jessica, Donaubauer, Anna-Jasmina, Welss, Jessica, Schneider, Ulrich, Gaipl, Udo S., Paulsen, Friedrich

“…Osteoarthritis (OA) involves activation and recruitment of immune cells to affected joints, including the production of pro-inflammatory cytokines. Here, a…”
Get full text

Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses - Pre-Clinical Evidence and Ongoing Clinical Applications by Derer, Anja, Deloch, Lisa, Rubner, Yvonne, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S

“…Radiotherapy (RT) primarily aims to locally destroy the tumor via the induction of DNA damage in the tumor cells. However, the so-called abscopal, namely…”
Get full text

Old and new facts about hyperthermia-induced modulations of the immune system by Frey, Benjamin, Weiss, Eva-Maria, Rubner, Yvonne, Wunderlich, Roland, Ott, Oliver J, Sauer, Rolf, Fietkau, Rainer, Gaipl, Udo S

“…Hyperthermia (HT) is a potent sensitiser for radiotherapy (RT) and chemotherapy (CT) and has been proven to modulate directly or indirectly cells of the innate…”
Get more information

Broadband microwave spiral applicator (105–125 MHz) for in vitro examinations of hyperthermia-induced tumor cell death forms – first analyses with human breast cancer cells by Walter, Jannik, Hader, Michael, Sengedorj, Azzaya, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S.

“…PURPOSELocal tumor heating with microwave applicators has been used in multimodal breast cancer therapies. This hyperthermia allows to target small regions…”
Get full text

Newly Synthesized Melphalan Analogs Induce DNA Damage and Mitotic Catastrophe in Hematological Malignant Cancer Cells by Poczta, Anastazja, Krzeczyński, Piotr, Ionov, Maksim, Rogalska, Aneta, Gaipl, Udo S, Marczak, Agnieszka, Lubgan, Dorota

“…Myeloablative therapy with highdoses of the cytostatic drug melphalan (MEL) in preparation for hematopoietic cell transplantation is the standard of care for…”
Get full text

Radiotherapy combined with docetaxel alters the immune phenotype of HNSCC cells and results in increased surface expression of CD137 and release of HMGB1 of specifically HPV-positive tumor cells by Grottker, Fridolin, Gehre, Simon, Reichardt, Clara M., Sengedorj, Azzaya, Jost, Tina, Rieckmann, Thorsten, Hecht, Markus, Gostian, Antoniu-Oreste, Frey, Benjamin, Fietkau, Rainer, Gaipl, Udo S., Rückert, Michael

“…•RCT-treated HPV-positive HNSCC tumors are associated with the release of HMGB1 and an increased expression of CD137•This highlights a potential mechanism for…”
Get full text

Identification and characterization of circular RNAs as novel putative biomarkers to predict anti-PD-1 monotherapy response in metastatic melanoma patients – Knowledge from two independent international studies by Zhou, Jian-Guo, Liang, Rui, Wang, Hai-Tao, Jin, Su-Han, Hu, Wei, Frey, Benjamin, Fietkau, Rainer, Hecht, Markus, Ma, Hu, Gaipl, Udo S.

“…Melanoma is the most aggressive skin malignancy with high morbidity. Anti-programmed cell death protein 1 (PD-1) monotherapy has been applied in metastatic…”
Get full text